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《肝脏病杂志》 1995-01
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STUDY OF HCV INFECTION AND VIREMIA IN PATIENTS WITH POST-TRANSFUSION HEP- ATITIS

Zhen-ya, Yang Dong-liang,Yu Zhi-qun, et al.Clinical Immunology Rescorch Unit,Tongji Hospital, Tongji Med University Wuhuan 430030  
169 patients of post-transsion hepatitis(PTH)were investigated for etiology with serological and PCR methods. Our result showed that HCV was the major causative agent of PTH in this studv。Some patients( 24/169 )were HBV markers positive too. Three patients were negative for all viral markers。Anti-HCV was detectable from 7 days to one year later after onseting of clinical symptoms,average time 54. 62 days. HCV RNA could be detected in early time of HCV infection(6 to 20 days later), average time 8. 72 days. A follow-up study of 84 PTH patients caused by HCV infection showed that all patients remained anti-HCV positive during the observation period(1.5~3years),but their HCV viremia had three forms:transient,persistent or interminant.The positive rate of HCV RNA higher than that of HBV DNA in patients with HCVlHBV superinfection(100%, 16. 67%,P0.01). All four HBV DNA positive patients were HBV DNA and HCV RNA positive alternatively during t he observation. This re- sult suggested that there was a suppression of HBV replication by HCV infection or the interaction of HBV and HCV during superinfection。
【Fund】: 国家八.五科技攻关重点资助
【CateGory Index】: R512.63
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