Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《CHINESE JOURNAL OF HEPATOLOGY》 1997-02
Add to Favorite Get Latest Update

FAS ANTIGEN AND FAS LIGAND EXPRESSION ON HEPATOCYTES: EFFECT ON HEPATIC APOPTOSIS IN VIRAL HEPATITIS B

Qin Bo, Zhang Dingteng, Ma Ying, et al. Viral Hepatitis Institute, Chongqing Medical University, Chongqing 630010  
Aim: To evaluate the role of Fas acttigen (FasAg) and Fas ligand (FasL) on hepatic apoptosis and necrosis ln viral hepatitis B. Methods: Paraffin sections (n=71 ) from patients with HBV infection (M: F 57: 14, age 20-79, CPH19, CAH24, cirrhods 9, fulminant hepatitais 19) were studied. 5 casa of atormal Uver tissues were studied as control. Apoptosis was detected by terminal deoxynucleotidyl transferase (TdT) mediated dUTP nick end labeling (TUNEL) . FaAg and FasL were determdned by immunohistochemistry. Results: Hepatic apoptosis and the expression of FasAg/FasL on hepatocytes were not detected in nonmal liver tissues. ln contrast to it, there were a strong reaction in TUNEL assay and FasAg/FasL expressed on hepatocytes in liver tissues infected with HBV. Our oborations also showed that FasAg and FasL were mainly detected in cytoplasm, and the degree of apoptosis and the expresdon of FasAg/FasL on hepatocytes had distinct difference in different hepatitis (P0.005). There was a positive correlation between degree of the expression of FasAg/FasL on hepatocytes and hepatic apoptods(P0.005). It was significantly that some hepatocytes expressed both FasAg and FasL, and many FasAg and/or FasL positive cells did not accompany with liver infiltrating lymphocytes. Conclusion: HBV perhaps induca expression of FasAg and FasL on hepatocytes. The interaction of FasAg and FasL on hepatocytes might result in liver damage, and death of hepatocytes probably occurs by autocrine or paracrine and fratricide mechanisms mediated by the hepatocytes themselves in viral hepatitis B .
【Fund】: 国家自然科学基金 卫生部及四川省卫生厅科学基金
【CateGory Index】: R512.62
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 WU Gang, YAN Ge, WU Guo-yi,et al. (Institute for Viral Hepatitis, Chongqing University of Medical Sciences,Chongqing 400010,China);The study of N-acetylcysteine-restrained apoptosis of human hepatocyte in vitro[J];Chongqing Medical Journal;2005-01
2 XING Wen-bin 1,LIU Li-na 2,L Shen 3 (1 The Sixth Hospital of Dalian,Dalian 116001,China;2 The First Afiliated Hospital of Dalian Medical,116011; 3 Department of Pathocogy,Dalian Medical Uniuersity,116027);The Expression of Fas\FasL in the liver tissue of chronic hepatitis B[J];Journal of Dalian Medical University;2001-03
3 GU Xiao hong, LI Qi fen, WANG Yu ming (Clinical Center of Infectious Disease, Southwest Hospital, Third Military Medical University, Chongqing 400038,China);Expression of HDAg and hepatocytic apoptosis in liver tissues of patients with hepatitis D[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;2000-05
4 YU Hong, CAO Zhi-chen, GENG Jian-ying, HE Zhan-guo, WANG Zheng-min, SUN Xiao-yun, WANG Zhong-huaDepartment of Hepatopathy, Bethune International Peace Hospital of PLA, Shijiazhuang 050082, China;Effect of interferon alpha on liver fibrosis in patients with chronic hepatitis B[J];Journal of First Military Medical University;2005-11
5 KONG Lingbin, AN Rui,SUN Zhi,et al. Union Hospital, Tongji medical College, Huazhong University of Science and Technology,430032;The anti-Fas ligand treatment in HBsAg-transgenic mice with chronic hepatitis B[J];Journal of Clinical Hepatology;2007-02
6 JIANG Qing-ping,GUO Ying, GUO Lin-lang, (Department of Pathology,Zhujiang Hospital,First Military University,Guangzhou 510282);Significance of apoptosis gene Fas,FasL and bax expression in chronic viral hepatitis[J];CHINESE JOURNAL OF CLINICAL HEPATOLOGY;2000-03
7 XING Wen-bin, AN Jie, ZHENG Mei, et al.(The Department of Infection The Number Six Hospital Da Lian 116001) LIU Li-na QIN Xiao-bo (The Department of Gastroenterology The Number One Clinical Hospital of Medical College DaLian 116001) LU Shen (The Departm;The Expression of Fas、FasL in the Liver Tissue of Chronic Hepstitis B[J];Chinese Journal of Clinical Hepatology;2002-05
8 YU - Hong, GENG Jian - ying, SUN Xiao - yun, et al.( Bethune Internat ional Peace Hospital of PLA Hepatology 050082);The clinic study of interfern alpha on liver flbrosis of patients with chronic hepatitis B[J];Chinese Journal of Clinical Hepatology;2005-06
9 Wu Gang, et al Research Institute for Viral Hepatitis, Chongqing University of Medical Sciences;THE STUDY OF LIPOPOLYSACCHARIDE-INDUCED APOPTOSIS OF HUMAN HEPATOCYTE IN VITRO[J];Journal of Luzhou Medical College;2004-04
10 ZHENG Rui Dan,LIN Fu Di,ZHANG Min Feng,et al.(Zhangzhou No.175 Hospital,Zhangzhou 363000,Fujin China);Relations of LPS level of plasmic endotoxin to expression of FasL in liver tissue and level of serumal sFasL in patients with chronic severe hepatitis B[J];Modern Practical Medicine;2001-08
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Lu Liangwei; Zhang Ping ; Xiong Yaokang; et al(Zhejiang College of TCM, Hangzhou 310009);Experimental Study about Huoxue Shenshi Decoction's Anti-fibrosis in Liver[J];Journal of Zhejiang College of Tcm;1999-04
2 LuLiangWei et al ( Zhejiang College of Traditional Chinese Medicine, Research School of Medical College of Zhejiang University);The Effect of Promoting the Blood flow and Resolving Dampness Recipe on Synthesis and Decomposition of Collagen Fiber of Experimental Hepatofibrosis Rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2002-06
3 Tian Kunlun,Xiao Nan, Diao Youfang, Liu Ping, Lin Ren (The Third Military Medical College,Chongqing (400042));The Protective Effect of N-acetylcysteine oil Intestine and Lung Damage Induced by Superior Mesenteric Artery Occlusion[J];CHONGQING MEDICAL JOURNAL;1999-02
4 FENG Ying kai,XU Jian cheng,YANG Qing hua,et al. (1.Institute of Respiratory Disease of P.L.A,Xinqiao Hospital,the Third Military Medical University,Chongqing 400037,China;2.Medical Information Center of Chongqing,Chongqing 400014,China);Apoptosis of CD4~+T cells and its effects in lipopolysaccharide-induced acute lung injury in rats[J];Chongqing Medical Journal;2004-01
5 XING Wen-bin 1,LIU Li-na 2,L Shen 3 (1 The Sixth Hospital of Dalian,Dalian 116001,China;2 The First Afiliated Hospital of Dalian Medical,116011; 3 Department of Pathocogy,Dalian Medical Uniuersity,116027);The Expression of Fas\FasL in the liver tissue of chronic hepatitis B[J];Journal of Dalian Medical University;2001-03
6 ZHEN Jiang, ZHENG Rui dan, TU Wei feng, CHEN Jun, XIAO Guang xia (Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing 400038,China);Preliminary study of enterogenous bacteria endotoxin translocation after intestinal ischemia reperfusion injury in rats[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;2000-05
7 LI Hai Min, DOU Ke Feng, TI Zhen Yu, LI Ren , WANG Zhi Gang, ZHANG Fu Qin Department of Hepatobiliary Surgery,Xijing Hospital, Fourth Military Medical University, Xian 710033, China;Effect of the sertoli cell chimeric in liver on the expression of the Fas/FasL in liver tissue and its significance[J];Journal of The Fourth Military Medical University;2003-12
8 ZHOU Gao Su 1, ZHANG Zhen Shu 2, WANG Fan 1, LIN Han Jun 1, ZHU Jie 1 1Ward for Senior Cadres, General Hospital, Beijing Military Region , Beijing 100026, China, 2Department of Gastroenterology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China;Effects of dexamethasone on Fas/Fas ligand expression and apoptosis of hepatocytes in rats with LPS-induced acute liver injury[J];Journal of The Fourth Military Medical University;2003-19
9 YANG Jie, DAI Lin, GUO Ya-bing, YANG Shou-chang, WANG Yan-jun, LUO Kang-xian Department of Infectious Diseases, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China;Application of multiplex PCR in genotyping of hepatitis B virus prevailing in Guangdong Province of China[J];Journal of First Military Medical University;2002-08
10 Luo Xinla 1,Chen Hua 2,Du Xinjia 3 1. Institute of Liver Disease,Hubei College of TCM, Wuhan 430061 2. Wuhan Hospital of TCM,Wuhan 430014 3. Jiayu Hospital of TCM,Jiayu 430072;Sera pharmacological Effect of Tidu Hugan Recipe on the Pyperplasia and Apoptosis of Hepatic Stellate Cells[J];Jounal of Hubei College of Trditional Chinese Medicine;2002-03
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Zhou Linyu,Wang Jian,Sun Youwen,et al Anhui Province Hispital.Hefei 230001;Effect of human growth hormone on cell cycle kinetics in GRC-1 cells line in vitro.[J];Anhui Medical Journal;2003-04
2 Liu Mingshe,Zhao Zhongfu,Wang Lan,et al.Department of Parasitology,Changzhi Medical College;Inhibition of Fas(CD95) Expression via Recombinant Adenovirus Vector of RNA Interference in vivo[J];Journal of Changzhi Medical College;2007-02
3 Qing Dingliang,Liu Linyun,Lin Sen Department of Clinical Laboratory,the Third Affiliated Hospital of Wenzhou Medical College,Zhejiang Ruian(325200);Significance of Changes of Expression of Peripheral Blood Lymphocytes CD44v6 in Patients with Chronic Hepatitis B[J];Journal of Radioimmunology;2009-01
4 ZHENG Min, CHENG Cong", ZHAO Ya-ping. et al. Department of General Surgery, the Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325027;Experimental study of applying recombinant human growth hormone to treat cirrhotic rats with ascites[J];Journal of Hepatopancreatobiliary Surgery;2006-01
5 DENG Zhi-hai//The People's Hospital of Lingui County,Lingui 541100,China;Progress on treatment of severe viral hepatitis[J];Acta Medicinae Sinica;2005-05
6 WENG Yin-biao,AO Ping-xing,GAO Hong(Department of science and technology of animals,Yunnan agriculture university,Kunming 650201,China);The Effect of Hepatocyte Apoptosis on the Liver Damnification which Cause by Endotoxin[J];China Animal Husbandry & Veterinary Medicine;2006-07
7 WANG Jun-zhi (Chongqing City Wanzhou District Hospital Affiliated Yazigou Medical Training Class,Chongqing 404000,China);Treatment of Selenium on Transmissible Hepatitis-induced Cell Death[J];Trace Elements Science;2003-04
8 Yao Limei, Chen Yuming, Yin Ruixing.(Dept.of Geriatric Cardiology,the First Affiliated Hospital of Guangxi Medical University, Nanning 530021 China);EFFECTS OF GROWTH HORMONE ON CARDIOMYOCYTE APOPTOSIS IN ADRIAMY-CIN-INDUCED CARDIOMYOPATHY IN RATS[J];Journal of Guangxi Medical University;2005-04
9 LIANG Jian, ZHANG Xi-liu, YANG Guang-ye, PANG Yu-sheng, YUAN Hai-feng, LIANG Jing-song, HUANG Ren-bin. Department of Gastroenterology,the Affiliated Ruikang Hospital of Guangxi Traditional Chinese Medical College, Nanning 530011, China;Observation of the Promotion Effect Taurine on Hepatic Stellate Cell's Apoptosis in Rat Hepatic Fibrosis Model[J];Journal of Sichuan University (Medical Sciences Edition);2005-03
10 SUN Yan-ling, ZHAO Jing-min, WANG Song-shan et al. 302 Hospital of PLA, Beijing 100039, China;Study of cellular apoptosis and its mechanism in lung and other organs of patients with severe acute respiratory syndrome[J];Medical Journal of Chinese People's Liberation Army;2004-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved