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Qin Bo, Zhang Dingteng, Ma Ying, et al. Viral Hepatitis Institute, Chongqing Medical University, Chongqing 630010  
Aim: To evaluate the role of Fas acttigen (FasAg) and Fas ligand (FasL) on hepatic apoptosis and necrosis ln viral hepatitis B. Methods: Paraffin sections (n=71 ) from patients with HBV infection (M: F 57: 14, age 20-79, CPH19, CAH24, cirrhods 9, fulminant hepatitais 19) were studied. 5 casa of atormal Uver tissues were studied as control. Apoptosis was detected by terminal deoxynucleotidyl transferase (TdT) mediated dUTP nick end labeling (TUNEL) . FaAg and FasL were determdned by immunohistochemistry. Results: Hepatic apoptosis and the expression of FasAg/FasL on hepatocytes were not detected in nonmal liver tissues. ln contrast to it, there were a strong reaction in TUNEL assay and FasAg/FasL expressed on hepatocytes in liver tissues infected with HBV. Our oborations also showed that FasAg and FasL were mainly detected in cytoplasm, and the degree of apoptosis and the expresdon of FasAg/FasL on hepatocytes had distinct difference in different hepatitis (P0.005). There was a positive correlation between degree of the expression of FasAg/FasL on hepatocytes and hepatic apoptods(P0.005). It was significantly that some hepatocytes expressed both FasAg and FasL, and many FasAg and/or FasL positive cells did not accompany with liver infiltrating lymphocytes. Conclusion: HBV perhaps induca expression of FasAg and FasL on hepatocytes. The interaction of FasAg and FasL on hepatocytes might result in liver damage, and death of hepatocytes probably occurs by autocrine or paracrine and fratricide mechanisms mediated by the hepatocytes themselves in viral hepatitis B .
【Fund】: 国家自然科学基金 卫生部及四川省卫生厅科学基金
【CateGory Index】: R512.62
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