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《Chinese Journal of Digestion》 2003-04
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Study on the anti-inflammatory mechanism of oxymatrine in dextran sulfate sodium induced colitis of rats

ZHENG Ping, NIU Feng li, LIU Wen zhong, et al. Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Second Medical University , Shanghai 200001, China  
Objective To investigate the anti inflammatory mechanism of oxymatrine(OM)in dextran sulfate sodium(DSS) induced colitis of rats. Methods Acute colitis was induced by giving 2% DSS orally in drinking water orally for 8 days. 26 male rats were randomized into OM treated group(group A,10 rats), DSS control(group B,10 rats) and normal control(group C, 6 rats). The rats in group A were injected muscularly with OM at the dosage of 63 mg·kg -1 ·d -1 from day 1 to day 11 and drank 2% DSS solution from day 4 to day 11. The rats in group B were treated with 0.9% saline in an equal volume as group A and drank 2%DSS solution from day 4 to day 11. The rats in group C were treated with 0.9% saline as group B from day 1 to day 11 and drank water normally. Diarrhea and bloody stool as well as colonic histology were observed. The levels of serum tumor necrosis factor α(TNF α)and interleukin 6(IL 6)were determined by ELISA, and nuclear factor κB(NF κB)activity and the expression of intercellular adhesion molecule 1(ICAM 1) in colonic mucosa were detected by immunohistochemistry method. Results Compared with DSS control group, the inflammatory symptoms and histological damages of colonic mucosa in OM treated group were significantly improved( P 0.02, P 0.05), the serum levels of TNF α, IL 6 and the expression of NF κB, ICAM 1 in colonic mucosa were significantly reduced( P 0.01, P 0.05, P 0.05, P 0.01). Conclusions The fact that OM can reduce the serum level of TNF α, IL 6 and the expression of NF κB and ICAM 1 in colonic mucosa in DSS induced colitis of rats indicates that OM may ameliorates the colonic inflammation and thus alleriate diarrhea and bloody stool.
【Fund】: 上海市临床医疗中心 (消化内科 )资助项目 ;; 上海市高等学校科技发展基金资助 ( 0 0B0 7)
【CateGory Index】: R574.62
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