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《Chinese Journal of Digestion》 2007-11
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The mechanism of electroacupuncture for regulating gastrointestinal motility in rabbits

HE Guo-dong NIU Wei-xin LIU Han et al.Surgery Department of Zhongshan Hospital,Fudan University,Shanghai 200032,China  
Objective To investigate the mechanism of regulating gastrointestinal motility by elec- troacupunturing point of"Zusanli"in rabbits.Methods Thirty adult rabbits were divided into control, electrical acupuncture point of"Zusanli"and non acupuncture point groups.The blood concentrations of motilin were detected at different times(before acupuncture and 15,30,45 and 60 min after acupunc- ture).Sixty min after acupuncture,the mice were sacrificed.The acetylcholine esterase and nitric oxide synthase(NOS)in gastric and jejunum tissues were examined.The electron microscope was used to observe the vesicles of nerve ending.Results The concentrations of motilin in electrical acupuncture group was significantly increased and reached the high peak at 45min.The activities of acetylcholine es- terase was increased significantly in electrical acupuncture group compared to control group[gastric tis- sue:(15 571±2876)pinel vs(9081±801)pinel,P0.01)and jejunum tissue:(18588±4909)pinel vs (11703±2050)pinel,P0.01].The activities of NOS in electroacupuncture group were significantly decreased compared to control group(gastric tissue:1.38±0.74 vs 4.71±1.06 and jejunum tissue: 2.10±0.94 vs 4.81±1.08,P0.01).The electron microscopy revealed that the number of vesicle without granula was significantly decreased in electrical acupuncture group compared to control group (gastric tissue:31.12±9.99 vs 57.45±9.18 and jejunum tissue:21.89±4.35 vs 56.70±9.35, P0.05).Conclusion Motilin,cholinergic nerve and non adrenergic/non-cholinegic nerve may be involved in the mechanism of regulating gastrointestinal motility by acupuncturing pointy of"Zusanli".
【Fund】: 上海市科学技术发展基金(014019030)
【CateGory Index】: R245
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