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THERAPEUTICEFFECTSOFRETINOlCACIDONEXPERI- MENTALLYINDUCEDPRECANCEROUSLESIONSOFTHE GLANDULARGASTRICMUCOSAINWISTARRATS

Li Chun- qi,Liu Wei- wen,fang Dian- chun,et al。DepartmentofGastroenterology,Southwest Hospital。 ThirdMilitaryMedicalCollege,Chogqing.  
he therapeutic effects of retinoic acid(RA)on experimentally induced precancerouslesions of the glandular gastric mucosa in Wistra rats were studied. Intestinal metaplasia(IM)anddysplasia in glandular stomach of rats were induced by giving both 003%ranitidinein diet and 50μg/ml N-m ethyl- N’-n itro- N-nitrosoguanidine(MNNG) in drinking water adlibitum for 20 weeks. From the beginning of the 36th week, RA(40mg/kg.body weight/day)was administered to rats of the treated group for 8 weeks and subsequently rats were killed。Results showed that the incidences of IM (72.0%), moderate and severe dysplasia (24.0%)andgastric cancer(0%)and the numbers of metaplastic glands in both the pyloric and fundicgland mucosa(130.2 ± 93.9, 51.5 ± 39.1) were significantly lower in RA treated group than inuntreated group(100.0%, 52.O%,16.0%,442.4± 230.0,247.4± 112.0 respectively) (P0.0l andP0.05).There was also significant difference(P0.01) in the incidence of sulfomucinpositive IM between the RA treated group(36.0%)and untreated group (84.0%).Obvious sideeffects of RA were not observed.It is therefore concluded that RA is an effective therapeuticagent for the precancerous lesions of glandular gastric mucosa in Wistar rats。
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