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《CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES》 2000-07
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Detection of extended-spectrum β-lactamases and drug sensitivity test in clinical isolates of the family Enterobacteriaceae in Shanghai

LIN Qing′an *, LUO Wentong, XIU Qingyu, et al. *Changzheng Hospital Affiliated to the Second Military Medical University, Shanghai 200003,China  
Objective To investigate extended spectrum β lactamases (ESBLs) production in clinical isolates of the family Enterobacteriaceae in Shanghai, and compare the resistant rates of ESBLs producing strains and non ESBLs producing strains to 11 antibiotics. Methods Double disk synergy test was used to detect ESBLs in 1 026 strains of the family Enterobacteriaceae; Kirby bauer agar diffusion method was used to judge drug sensitivity. Results 34.31% of strains of the family Enterobacteriaceae were considered ESBLs producers by double disk synergy test. The prevalences of ESBLs in isolates of Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae were 37.40%, 30.21% and 41.82% respectively. Except Imipinem and Cefmetazole, the resistant rates of ESBLs producing strains to other 9 antibiotics were much higher than that of non ESBLs producing strains( P 0.01). The resistant rates of Imipinem to ESBLs producing strains were the lowest. Conclusions The prevalence of ESBLs in clinical isolates of the family Enterobacteriaceae in Shanghai was high; it is necessary for clinical laboratory to detect ESBLs in clinical isolates of the family Enterobacteriaceae routinely. The resistant rates of ESBLs producing strains to most antibiotics were high. Imipinem and Cefmetazole were the effective antibiotics to infections caused by ESBLs producing strains.
【CateGory Index】: R978.1
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