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Pathologic review of 5 050 pulmonary tuberculosis cases

HUANG Zhiying, ZHOU Mian, L Fudong. Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149  
Objective To summarize the pathomorphologic changes of pulmonary tuberculosis and the relationship between those changes and the combined chemotherapy regimens. Methods Observing the pathological changes in 5 050 cases with pulmonary tuberculosis, and the relationship between three different combined chemotherapy regimens HSP, HRS, HRZS and the pathological changes of pulmonary and bronchial tuberculosis. Results The rate of surgical excision of caseous cavities and fibrous cavities declined markedly in cases treated by HRS and HRZS regimens ( P 0.01). Whereas, after treated by HSP, HRS and HRZS regimens, the rate of surgical excision of tuberculoma were 26.82%(897/3 345), 41.24%(464/1 125) and 47.8%(277/580) respectively which showed a rising tendency ( P 0.01). Open healing cavities were found in 42 patients. Conclusions The effects of combined rifampicin and pyrazinamide chemotherapy caused the changing of pathologic types of pulmonary tuberculosis, that is: the increased proportion of tuberculoma and the decreased proportion of caseous and fibrous cavities. Tuberculoma ought to be taken into account in the classification of tuberculosis.
【CateGory Index】: R521
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