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《CHINESE JOURNAL OF STOMATOLOGY》 2000-02
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Experimental study on the influence of Gynostemma pentaphyllam Mak upon point mutation of Ha ras oncogene in blocking leukoplakia from canceration

Zhou Zengtong, Tang Guoyao, Zhong Wenjing, et al. Department of Oral Medicine,School of Stomatology,Shanghai Second Medical University,Shanghai 200011, China  
Objective To study the influence of Gynostemma pentaphyllam Mak (GP) upon point mutation of Ha ras oncogene the molecular mechanism of GP in blocking canceration ,and the relationship between Ha ras oncogene and canceration of leukoplakia Methods DMBA induced carcinogeneses of the buccal pouch mucosa of the hamsters were divided into leukoplakia model group(LKG)and GP treated group(GPG) Point mutation (codon 61) of Ha ras oncogene was detected by PCR SSCP in both groups Results The mutation incidence of LKG was 22 96% , while the mean incidence of GPG was 7 59% (The incidences of C 20 OH group, glucoside group and aglucon group were 5 32%, 6 25% and 11 00% respectively) When treated with DMBA for 4 to 8 weeks, the mutation incidence of LKG ranged from 11 10% to 40 00%, while GPG ranged from 0 to 10 70% Conclusions GP has outstanding cancer blocking effect chiefly affected by free C 20 OH Mutation of Ha ras oncogence plays an important role in leukoplakia canceration
【CateGory Index】: R781.5
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【References】
Chinese Journal Full-text Database 4 Hits
1 HUANG Wen-xia1,CHEN Zuo-liang1,ZHENG Yan-fen1,ZHAN Jun-yan1,YANG Tian-ci2,CHAO Peng-li2. 1.Xiamen Stomatological Hospital,Fujian Medical University,Fujian Xiamen 361003,China;2.Zhongshan Hospital Affiliated to Xiamen University,Fujian Xiamen,361000,China.;Qilan Granulates'effect on peripheral blood lymphocyte subsets of SD rats in 4NQO-induced rat tongue carcinogenesis[J];Journal of Clinical Stomatology;2010-08
2 LOU Jia-ning,GE Shu-yun,ZHOU Zeng-tong.1.Department of Stomatology,First People's Hospital,Shanghai Jiaotong University;Shanghai 200080,China;2.Department of Oral Medicine,College of Stomatology,Ninth People's Hospital,School of Medicine,Shanghai Jiaotong University;Research Institute of Stomatology;Shanghai Key Laboratory of Stomatology,Shanghai 200011,China.;The study of altered succinate dehydrogenase gene expression by Gypenosides during rat tongue OLK carcinogenesis induced by 4-Nitroquinoline 1-Oxide.[J];Journal of Clinical Stomatology;2010-12
3 Chen Zuo-liang,Huang Wen-xia,Zheng Yan-fen,et al.Xiamen Stomatological Hospital,Fujian Medical University,Xiamen 361003;Effects of Qilan Granulates on Expression of Survivin in 4NQO-induced Rat Tongue Carcinogenesis.[J];Journal of Oral Science Research;2011-06
4 CHEN Zuoliang,ZHENG Yanfen,HUANG Yiqi,et al.Xiamen Dental Hospital,Fujian Medical University,Xiamen 361003;Effects of Qilan Granulates on expression of Bcl-2 and P53 in 4NQO-induced rat tongue carcinogenesis[J];Journal of Modern Stomatology;2010-01
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Zhou Zengtong;Xu Weining;Zhang Shuilong, et al(Departmentof Oral Medicine, School of Stomatology,SSMU, Shanghai 200011);The study of influencing cellular dynamics of gynostemma pentaphyllum on golden hamster cheek pouch premalignancy[J];SHANGHAI JOURNAL OF STOMATOLOGY;1997-02
2 Zhou Zengtong, et al. Stomatological College , The Second Medical University of Shanghai,Shanghai 200011.;Anticarinogenic effects of Gynostemma Pentaphyllum Mak on DMBA-Induced malignancy in Golden Hamster cbeek poach.[J];Journal of Practical Stomatology;1995-04
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 ZHANG Yong,DING Guohua,ZHANG Jiane,et alDivision of Nephrology,The Affiliated Renmin Hospital of Wuhan University,Wuhan (430060);Effect of Gypenosides on Expression of Connective Tissue Growth Factor(CTGF) in UUO Rats with Renal Tubulointerstitial Fibrosis[J];Chinese Journal of Integrated Traditional and Western Nephrology;2005-07
2 LOU Jia-ning,ZHOU Zeng-tong.Department of Stomatology,Shanghai First People's Hospital,Shanghai Jiaotong University,Shanghai 200080,China.;Altered telomerase activity during chemoprevention of experimental hamster cheek pouch carcinogenesis by Gynostempa Pentaphyllum Mak.[J];Journal of Clinical Stomatology;2008-04
3 ZHANG Yong,XIAO HouQin,ZHANG JieE,et al.Division of Nephrology,The Affiliated Taihe Hospital of Yunyang Medical college,Shiyan 442000,China;The protective and therapeutic effects of Gypenosides in patients with early stage chronic renal failure[J];Journal of Clinical Internal Medicine;2007-10
4 Zhou Zengtong;Xu Weining;Zhang Shuilong, et al(Departmentof Oral Medicine, School of Stomatology,SSMU, Shanghai 200011);The study of influencing cellular dynamics of gynostemma pentaphyllum on golden hamster cheek pouch premalignancy[J];SHANGHAI JOURNAL OF STOMATOLOGY;1997-02
5 YI Xiang-xi1,2,3 , ZENG Shi-xiang4 (1.Guangxi University of Traditional Chinese Medicine, Nanning 530001, Guangxi, China; 2. South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, Guangdong, China;3. Graduate University of Chinese Academy of Sciences,Beijing 100049, China; 4.Nanning Light Industry and Food Engineering Institute, Nanning 530031, Guangxi, China);THE EXTRACTED METHOD OF SAPONIN AND POLYSACCHARIDES FROM GYNOSTEMMA PENTAPHYLLUM[J];Food Research and Development;2009-05
6 Zhou Zengtongj Zhou Yongmei, Zhang Shuilong School of Stomatology, Shanghai Second Medical University, Shanghai 20001;The Compound of Gynostemma Pentaphyllum Influencing the variation of Proliferating Cell Nuclear Antigen During the Course of Carnomatous Conversion of Golden Hamster Cheek Pouch[J];Journal of Modern Stomatology;1997-04
7 ZHANG Qing Bei 1,MA Jun Jiang,CHAO Zhi Xian 2,LIN Zhi Bin (Dept of Pharmacology, Beijing Medical University, Beijing 100083);Therapeutic role and its mechanism of gypenosides on delayed healing of experimental gastric ulcer induced by NCTC11637 strain HP in rats[J];CHINESE PHARMACOLOGICAL BULLETIN;1999-03
China Proceedings of conference Full-text Database 1 Hits
1 ;The efficacy evaluation of the Krypton laser PDT for the oral mucosa dysplasia in the DMBA-treated hamsters.[A];[C];2005
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LIU Ze-qing,CUI Wen-ming,WANG Wei, SUN Zheng,HAN Chi,LI Ning ˇ (Institute of Nutrition and Food Safety,Chinese Center for Prevention and Control,Beijing100050,China);Chemopreventive Effect of Curcumin on DMBA-induced Oral Carcinogenesis in Hamsters[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-04
2 Gao Ling,Wang Yixian,Zhang Qinfen Jiangsu Institute of Cancer Research,Nanjing 210009;ANTITUMOR EFFECT IN VITRO OF TRADITIONAL CHINESE MEDICINE 901[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1997-04
3 LIU Xia,WANG Ping-jun,Xu Fu-xin (The Frist People's Hospital of Wuhu,Anhui Wuhu 241000,China);STUDY ON GYPENOSIDES INHIBITING NEOPLASM GROWTH AND ELEVATING IMMUNOLOGICAL FUNCTION IN LEWIS LUNG CANCER OF MICE[J];Journal of Anhui Traditional Chinese Medical College;2001-01
4 LI Ping,ZHANG Mei (Dept.of TCM,Anhui Provincial Hospital,Anhui Hefei 230001,China);EFFECTS OF ASTRAGALUS ON APOPTOSIS RELATED GENE EXPRESSION IN RATS AFTER CEREBRAL ISCHEMIA[J];Journal of Anhui Traditional Chinese Medical College;2001-04
5 HUANG Yun-Hong1, ZHANG Sheng-Hua1, ZHEN Rui-Xian2, XU Xian-Dong1, ZHEN Yong-Su1 1.Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,100050, P.R.China 2.The First Peoples Hospital of Kaiping City, Kaiping,Guangdong,529300, P.R.China;Asiaticoside Inducing Apoptosis of Tumor Cells and Enhancing Anti-tumor Activity of Vincristine[J];Chinese Journal of Cancer;2004-12
6 Chen Nipi,Li Wanli,Ding Zhishan,et al Zhejiang Traditional Chinese Medical University,Hangzhou(310053);Experimental Study on Antineoplastic Effect of Total Saponins from Shenmai[J];Journal of Zhejiang University of Traditional Chinese Medicine;2006-03
7 SUN Zheng et,al Beijing Hospital for Stomatology Capital University of Medical Sciences,Beijing 100050;STUDIES OF THE EFFECTS OF ZHENSHENPING ON DMBA-INDUCED ORAL CARCINOGENESIS IN HAMSTERS[J];BEIJING JOURNAL OF STOMATOLOGY;2000-01
8 GUAN Xiao-bing et al.Faculty of Stomatology,Capital University of Medical Sciences.Beijing 100050;INHIBITORY EFFECTS OF SPIRULINA PLATENSIS ON ANGIOGENESIS OF DMBA/TPA-INDUCED BUCCAL POUCH CARCINOGENESIS IN HAMSTERS[J];Beijing Journal of Stomatology;2004-02
9 SUN Zheng, LI Ning, LIU Xiao-yong, WANG Rong.Faculty of Stomatology , Capital University of Medical Sciences,Beijing 100050;Experimental and clincal study on Zengshengping's preventive effect on oral cancer[J];Beijing Journal of Stomatology;2005-03
10 LI Fang,SUN Zheng,WU Hong-ru,CHEN Xiao-xin,LI Ning.Capital Medical University School of Stomotology,Beijing 100050,China;Chemopreventive effect of Zyflamend on DMBA-induced oral precancerous lesions in hamsters[J];Beijing Journal of Stomatology;2007-02
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 ;口腔白斑的研究进展[J];Contemporary Medicine;2011-19
【Secondary Citations】
Chinese Journal Full-text Database 6 Hits
1 Chen Zuoliang;Gong Yuqin;Chen Hanzhenet al(College of Stomatology,Hubei Medical University);Scanning Electron Microscopic Study of Experimental Leukoplakic Patches of Hamster Cheek Pouch Compared with Human Oral Leukoplakia[J];WEST CHINA JOURNAL FOF STOMATOLOGY;1994-01
2 Song Yufeng;Wen Yuming(West China University of Medical Sciences);A Histologic Study of Golden Hamster Cheek Pouch Carcinogenesis Induced by DMBA[J];WEST CHINA JOURNAL FOF STOMATOLOGY;1994-02
3 WU Ji-Liang,QIU Pei-Lun,LIU Jun-Tian,MU Qi-Yun,XIN Dong-Sheng (Dept Pharmacology,Xian Medical University,Xian 710061);Effects of gypenosides on platelet aggregation release and cAMP level in rabbits[J];Chinese Journal of Pharmacology and Toxicology;1990-01
4 WANG Zhu-Yun, QIU Pei-LunDepartment of Pharmacology, Xi'an Medical University, Xi'an 710061;Protective effect of gypenosides on acute incomplete cerebralischemia in rabbits[J];Chinese Journal of Pharmacology and Toxicology;1992-03
5 Chen Yuchun (Fujian Chinese Medical and Pharmaceutical Institute, Fuzhou 350003)Gao Yiqin (Fuzhou Infectious Disease Hospital, 350004);Gypenosides Stimulating the Activation and IL-2 Excretion of lymphoevtes[J];Journal of Chinese Medicinal Materials;1994-04
6 Wang Zhi-jie;Li Xin-zhi;Cheng Jing-chen Verus Research Institute, Hubei Medical College, Wuhan Huazhong Normal University, Wuhan;INHIBITORY EFFECT OF GYNOSTEMMA PENTAPHYLLUM ON EHRLICH’S ASCITES CARCINOMA[J];Tumor;1990-06
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