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Experimental study on the influence of Gynostemma pentaphyllam Mak upon point mutation of Ha ras oncogene in blocking leukoplakia from canceration

Zhou Zengtong, Tang Guoyao, Zhong Wenjing, et al. Department of Oral Medicine,School of Stomatology,Shanghai Second Medical University,Shanghai 200011, China  
Objective To study the influence of Gynostemma pentaphyllam Mak (GP) upon point mutation of Ha ras oncogene the molecular mechanism of GP in blocking canceration ,and the relationship between Ha ras oncogene and canceration of leukoplakia Methods DMBA induced carcinogeneses of the buccal pouch mucosa of the hamsters were divided into leukoplakia model group(LKG)and GP treated group(GPG) Point mutation (codon 61) of Ha ras oncogene was detected by PCR SSCP in both groups Results The mutation incidence of LKG was 22 96% , while the mean incidence of GPG was 7 59% (The incidences of C 20 OH group, glucoside group and aglucon group were 5 32%, 6 25% and 11 00% respectively) When treated with DMBA for 4 to 8 weeks, the mutation incidence of LKG ranged from 11 10% to 40 00%, while GPG ranged from 0 to 10 70% Conclusions GP has outstanding cancer blocking effect chiefly affected by free C 20 OH Mutation of Ha ras oncogence plays an important role in leukoplakia canceration
【CateGory Index】: R781.5
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