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《Chinese Journal of Industrial Hygiene and Occupational Diseases》 2004-05
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Relationship between bleomycin-induced pulmonary fibrosis and vascular endothelial cell injury

WEI Jing- guo , CUI Guang-bin , WANG Wei, WEI Long-xiao, LIANG Guo-min, SONG Li-jun, XV Jia-kuan. Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi' an 710038, China  
Objective To explore the relationship between the injury of vascular endothelial cells and formation of lung fibrosis by bleomycin(BLM) in rats. Methods The rats of experimental groups were treated with bleomycin intratracheally to induce pulmonary fibrosis.The expression of vascular endothelial growth factor( VEGF) in pulmonary tissues were analyzed qualitatively and quantitatively by immunohistochmistry and image analysis system. Results (1)Histology:Edema in rat alveoli and alveolar septum,inflammatory cells exudation, degeneration and necrosis of type I and type Ⅱ alveolar epithelial cells(AETⅠ and AETⅡ ), ruptured alveolar basment membrane , as well as swollen vascular endothelial cells and karyopyknosis were observed in 3 d and 7 d after treatment with BLM. AET Ⅱ proliferation, with more fibroblasts in alveolar septum, and new capillary vessel formation in 7,14 d,as well as thickened alveolar septum, damaged alveolar structure, and obvious pulmonary tissue fibrosis in 28 d after treatment with BLM were observed. (2)Immunonistochemistry:in normal control, VEGF expressed weakly in pulmonary tissue distributing mainly in AETⅡ ,bronchial epithelial cells,alveolar macrophages and leydig's cells. While in bleomycin treated groups, the expression of VEGF increased markedly. The expression in AET Ⅱ , and pulmonary macrophage were signifiantly higher than that in control in 3 d to 28 d( P 0.05, P 0.01) .The rat ley-dig' s cells also had higher expression of VEGF in 7,14,28 d( P 0.05, P 0.01). Conclusion The high expression of VEGF is related to vascular endothelial cells injury which may be one of important factors in the formation of bleomycin-induced pulmonary fibrosis.
【CateGory Index】: R563.9
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