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《Chinese Journal of Industrial Hygiene and Occupational Diseases》 2006-05
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Relationship of trichloroethylene-induced medicamentosa Uke dermatitis to HLA-DMA and HLA-DMB

WE Fei, HUANG Han-tin , HUANG Zhen-lie, LI Lai-yu , LIANG Li-yan , CHEN Xue-min . Department of Environmental Hygiene, Tongji medical College , Huazhong University of Science and Technology , Wuhan430030, China  
Objective To investigate the susceptibility of trichloroethylene-induced medicamentosa like dermatitis by comparing the frequency of HLA-DMA and HLA-DMB in patients with trichloroethylene-induced medicamentosa like dermatitis and in normal controls. Methods The DNA of lymphocytes in 61 patients with trichloroethylene-induced medicamentosa like dermatitis and in 60 people as the normal control were abstracted by using touchdown PCR amplification of HLA-DMA and HLA-DMB.Then through restriction fragment length polymorphism (RFLP) and sequence base typing, the alleles and genotypes were confirmed. The frequency of HLA-DMA and HLA-DMB in the two groups was compared. Results The HLA-DMA * 0101 allele frequency in patients with trichloroethylene-induced medicamentosa like dermatitis was significantly higher than in the control group(71 .3% vs 55 .0% , P 0.05) .The allele frequency of HLA-DMA * 0103 was significantly higher in the patient group than in the control group(11.5% vs 3.3% ,P0.05).The ratio of * 0102 homozygotes of HLA-DMA * 0102 in the patient group was significantly higher than in the control group(25.0% vs 8.2% , P 0.05) .The ratio of * 0102 heterozygotes of HLA-DMB * 0101 in the patient group was lower than in the control group( P 0.05). Conclusion The polymorphisms of DMA may be related to the susceptibility of the patients with trichloroethylene-induced medicamentosa like dermatitis.
【Fund】: 国家自然科学基金资助项目(30500401);; 广东省科技厅计划项目(20040110337);; 广东省医学科研基金(2004B0004)
【CateGory Index】: R758.21
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