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《Chinese Journal of Geriatrics》 2004-05
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Protective effect of Ginkgo biloba extract on acute lung injury in aging rats and renal function damage induced by acute lung injury

SUN Ying *,SUN Ren-yu,DU Ye-wei, WANG Shi-wen. *Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China  
Objective To investigate whether gingko biloba extract (GBE) have protective effect on acute lung injury(ALI)induced by Lipopolysaccharide ( LPS) in aging rats and renal function damage induced by ALI. Methods Male aging Wistar rats(36) were used in the study. LPS group (LPS, iv route, 5mg/kg body weight) and GBE+LPS group (GBE was given starting from 7 days before experiment, once a day oral administration). The blood, lung and kidney samples were collected at 2 or 6 hours after LPS or saline administration. Results Compared with the aging control, ALI was obviously observed in LPS group, blood creatinine and urea nitrogen were increased significantly from (68.7± 6.9) mol/L and (5.9±0.6) mmol/L to (94.7±10.3) mol/L and (11.4±1.9) mmol/L, respectively (P0.01) at 6 hours after LPS administration. In LPS group, MDA and NO 2 -/NO 3 -contents in blood and lung tissue were all increased significantly (P0.01) at 2 and 6 hours. But GSH-P X and Na +-K +-ATPase activities in lung tissue were decreased significantly (P0.01) at 2 and 6 hours after LPS administration. Whereas MDA, NO 2 -/NO 3 - contents in renal tissue were increased obviously (P0.01), and Na +-K +-ATPase and GSH-P X activities were decreased markedly (P0.01) only at 6 hours after LPS administration. All these changes were significantly attenuated in the GBE+LPS group (P0.05). Conclusions ALI was caused by intravenous injection of LPS (5 mg/kg body weight ) in aging rats. Renal function damage could be induced by ALI in aging rats. GBE showed a protective effect on ALI and renal function damage in this animal model.
【Fund】: 国家重点基础研究规划项目 ( 973 )基金 (G2 0 0 0 0 5 70 0 4)
【CateGory Index】: R285
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