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《Bulletin of Chinese Cancer》 2004-07
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Impact of Reduced CoenzymeⅠon Inhibition of Human Gastric Cancer Cells by Antitumor Drugs

YU Wei-hong1,PAN Tie2,LI Xiao-xia2(1.Liaoning Province Tumor Institute,Shenyang 110042,China;2.Liaoning Province Tumor Hospital,Shenyang 110042,China)  
To investigate the impact of reduced coenzyme Ⅰ(NADH) on inhibition of human gastric cancer cells by antitumor drugs.The inhibition rate of tumor cells with NADH and antitumor drugs of 5-Fu,Vp-16, DDP, EPI and MMC were observed by MTT assay.NADH markedly decreased the inhibition rate of 5-Fu,Vp-16, DDP,and EPI on tumor cells (P0.05)and significantly increased the sensitivity of human gastric cancer cells to MMC(P0.01).[Conclusions]NADH may be an important adjuster for chemotherapy.
【CateGory Index】: R735.2
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