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《Chinese Journal of Physical Medicine》 1998-04
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Effect of Helium-Neon Laser on Pulmonary Surfactant in Prevention of Pulmonary Hemorrhage

Zhu Liewei, Shi Bingpei, Jin Qinli, et al. Department of Pediatrics, Shanghai Medical University, Shanghai 200032  
Objective To investigate the biological effect of helium-neon laser on the endogenous pulmonary surfactant(PS) and to establish a comprehensive plan for the prevention of pulmonary hemorrhage. Methods Helium-neon laser was adopted for radiation on rat pulmonary hemorrhage model. The survival rate, pulmonary pathology, pulmonary function index of the experimental rats were compared, and the elements in the bronchoalveolar lavage fluid(BALF) were analyzed for its ultrastructure. Results As compared with the control group, the survival rate of the radiation group was significantly improved. Pulmonary pathology and pulmonary function index apparently improved, and correlated with the findings of BALF statistically. Ultrastructural observation showed that the survival rats radiated did not develope obvious pathological changes and the type Ⅱ cells produced a large quantity of lamellar bodies as pulmonary surfactant. Conclusion The low-energy, helium-neon laser increases the endogenous PS of type Ⅱ cells, reduces the hemodynamic effect on lung and prevents pulmonary hemorrhage.
【CateGory Index】: R454
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