The study on the serum hormone level in macaques irradiated by electromagnetic pulse(EMP)
CAO Xiaozhe *, WANG Dewen, ZHAO Meilan, GAO Yabing, CUI Xuemei, PENG Ruiyun, ZHANG Youren. *Beijing Institute of Radiation Medicine, Beijing 100850, China
Objective Under the observation of changes of plasma levels of estradiol (E2), testosterone (Testo), thyroid stimulating hormone (TSH), free thyronine (FT4), cortisol (Cort), aldosterone (Ald), and human growth hormone (HGH) of the macaques irradiated by EMP, the influence of EMP on endocrine system was evaluated. Methods The veinous blood was abstracted from five adult macaques (2 males and 3 females) before being irradiated as self control samples. All the five macaques were irradiated by high field strength of EMP (6×10 4V/m, 30 time with in 5 minutes). The blood was obtained with the same method as above at 1h, 6h, 24h, 3d, 7d, 14d and 28d following the irradiation, and the hormone levels were measured by FT630 automatic radio immunity analyzer. Results The serum E2 was increased at early stage (6h), but dropped significantly at 28 h( P 0.05). Testo and TSH were duratively decreased, and increased contrararily at 28d ( P 0.05). FT4 and HGH were decreased significantly and reached lowest point at 28d ( P 0.05 ); The levels of Cort showed a fluctuated results, however it decreased to lowest point at 28d ( P 0.05); Levels of Ald had no obvious change comparing with the control ( P 0.05 ). Conclusion Turbulence in levels of serum hormones of macaques could be induced by EMP, which might be the result of its early effects, in the mean time, this could be attributed to the durative effects. It is inferred that EMP may exert curtain harmful effect to the endocrine system of macaques.