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《Chinese Journal of Physical Medicine》 1998-01
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Plasma Level of Atrial Natriuretic Factor and Changes of Left Atrial Function in Patients with Coronary Heart Disease

Tong Xiaoming,Sun Baozhen,Gao Qingping,et al. Zibo City Hospital,Zibo,255036   
Objective To investigate the relationship between plasma atrial natriuretic factor(ANF) levels and changes of left atrial hemodynamics in patients with coronary heart disease (CHD). Methods Plasma ANF level and left atrial function as well as the changes of hemodynamics in 106 patients with CHD and 50 normal control (NC) group were measured by two dimensional Doppler echocardiography and radioimmunoassay.Results The plasma level of ANF concentrations in 36 angina pectoris(AP) group, 40 myocardial infarction(MI) group and 30 ischemic cardiomyopathy (ICM) group was higher than NC group (P0.01 or 0.001).Significant linear correlation existed between plasma level of ANF and the indexes of left atrial function:left atrial volume(LAV), left atrial tension(LAT),left atrial pressure(LAP),left atrial diameters( LAD),left atrial stroke volume(LASV) and left atrial ejection fraction(LAEF);the correlation coefficients were 0.79,0.74,0.69,0.682,0.66, 0.64 (P0.01 or 0.001).Moderate linear correlations existed between plasma level of ANF and left ventricular systolic or diastolic function indexes: left ventricular ejection fraction (LVEF),left ventricular diameters ( LVD) ,peak filling rate (PFR),peak velocity A and A/E ratio: the correlation coefficients were -0.60,0.58,-0.58,0.52,0.44 (P0.01 or 0.001). Conclusion Detection of ANF level is usful in estimation of left atrial ventricular hemodynamic changes in patients with CHD.
【CateGory Index】: R541.4
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