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《CHINESE JOURNAL OF PSYCHIATRY》 2000-01
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A study on monoamine neurotransmitters in plasma and CSF in patients with post stroke depression

L Luxian, SONG Jinggui, LU Hong, et al The Second Affiliated hospital of XinXiang Medical College, Henan 453002, China  
Objective To explore the relationship between the post stroke depression (PSD) and monoamine neurotransmitters in plasma and cerebrospinal fluid (CSF) Method The concentrations of monoamine neurotransmitters in plasma and CSF in 32 post stroke depression patients, 30 post stroke without depression patients and 28 normal adults were measured using the high performed liquid chromatography with electrochemical detector Results The neurotransmitters′ concentrations in plasma and CSF in PSD patients [DA=(2 6±0 4) μmol/L,(2 0±0 3) μmol/L; NE=(0 19±0 06) μmol/L,(0 14±0 06) μmol/L; 5 HT=(1 09±0 30) μmol/L,(0 60±0 12) μmol/L] were obviously lower than that in post stroke without depression patients [DA=(3 2±0 5) μmol/L,(2 6±0 4) μmol/L;NE=(0 31±0 12) μmol/L,(0 28±0 08) μmol/L;5 HT= (1 31±0 40) μmol/L ,(1 11±0 40)μmol/L] and normal adults [DA=(2 9±0 5) μmol/L,(2 2±0 6) μmol/L; NE=(0 27±0 70) μmol/L,(0 23 ±0 08) μmol/L;5 HT=(1 19±0 30) μmol/L,(0 88±0 07) μmol/L] The most obviously decline was found in the patients with left CVD and anterior stroke There was a negative correlation between the severity of depression and monoamine neurotransmitters in plasma and CSF Conclusion The results of this study suggested that PSD is related to the decline of monoamine neurotransmitters in plasma and CSF
【Key Words】: Cerebrovascular disorders Depressive disorder Biogenic amine neurotransmitters
【Fund】: 河南省科委自然科学基金
【CateGory Index】: R749.13
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