Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Anesthesiology》 2004-07
Add to Favorite Get Latest Update

The protective effects of pretreatment with Sini Decoction on the lungs against intestinal ischemia-reperfusion induced injury in rats

LIU Ke-xuan , LIU Chui-liang, WU Wei-kang, et al. " Department of Anesthesiology, First Hospital, Sun Yat-sen University, Guangzhou 510080, China  
Objective To investigate the effects of pretreatment with Chinese herbal Sini Decoction ( SND) on the acute lung injury induced by intestinal ischemia / reperfusion (I/R) .Methods Thirty-two healthy SD rats of both sexes weighing 275-300 g were randomly divided into four groups of 8 animals : (Ⅰ) control group in which sham operation was performed, ( Ⅱ) I/R group in which superior mesenteric artery was clamped for 1 h followed by 3 h reperfusion; (Ⅲ) and (Ⅳ) SND group 1 and 2 in which SND 3 g·kg-1 ( Ⅲ) or 6 g·kg-1 (Ⅳ) was given via gastric tube every day for 3 days before I/R. Carotid artery was cannulated for MAP monitoring. The animals were sacrificed by decapitation at the end of 3 h reperfusion. Blood was collected and the lungs were immediately removed for determination of lung water content [ (wet weight - dry weight) / wet weight ×100% ], lung NO, endothelin-1 (ET-1) and MDA contents and SOD activity, lung permeability index (BALF protein concentration/serum protein concentration) and microscopic examination. Results SND pretreatment significantly alleviated the hypotension and morphological changes of the lungs induced by intestinal I/R. Lung water content, lung permeability index and lung MDA and NO contents increased significantly whereas lung SOD activity significantly decreased in I/R group ( group Ⅱ) compared with those in control group ( P 0.01 or 0.05). There was no significant difference in lung ET-1 content between control and I/R group, resulting in increased NO/ET-1 ratio. SND pretreatment significantly prevented the above changes induced by intestinal I/R. Lung SOD activity was significantly higher in the two SND groups than that in I/R group but was still significantly lower than that in control group. Conclusion SND can attenuate the intestinal I/R induced lung injury by its antioxidant activity and by reducing the NO generation and maintaining normal NO/ET-1 ratio.
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 LIU Ke-xuan,HUANG Wen-qi;Protective effects of preconditioning and postconditioning against the intestines I/R injury[J];China Continuing Medical Education;2010-04
2 LIU Chui-liang,LI Yu-juan,LIU Ke-xuan,et al.Department of Anesthesiology,TCM Hospital of Guangdong Province,Guangzhou 510120,China;Effect of electric stimulation of vagus nerve on hepatic injury induced by intestinal ischemia-reperfusion in rats[J];Chinese Journal of Anesthesiology;2006-10
China Proceedings of conference Full-text Database 1 Hits
1 Zengping,Wu Weikang,Yang Yiyu,Guangzhou Children's Hospital(510120);The early intervention.of Sinitang decoction in SIRS model rats[A];[C];2008
【Citations】
Chinese Journal Full-text Database 4 Hits
1 Huang Luosheng; Zhao Weichun; Xia Yufeng(School of Traditional chinese Medicines, Nanjing 210038;Institute of Drug Inspection,Tianjing 300070);Effect of Preparation Methods on the Content of Alkaloids and Glycyrrhetic Acid in Sini Injection[J];JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY;1999-05
2 Wu Weikang;Luo Hanchuan and Hou Can(Sun Yatsen University of Medical Sciences,Guangzhou 510089);In Vitro Experiment on Scavenging Oxy-radical and SuppressingMyocardial Lipid Peroxidation with Sini Decoction[J];CHINA JOURNAL OF CHINESE MATERIA MEDICA;1995-11
3 LI Xin-yu 1, JING Bing-wen 2, CHEN De-chang 2, et al. 1Dapartment of Emergency, Ulumqi General Hospital of Lanzhou Command, Ulumqi 830000. 2 Emergency Center, Changzheng Hospital, Second Military Medical University, Shanghai 200003,China;Studies on prophylactic-therapeutic effects of rhubarb on pulmonary microvascular injury induced by intestinal ischemia-reperfusion in rats[J];Chinese Journal of Critical Care Medicine;2002-04
4 YAN Guangtao,HAO Xiuhua,XUE Hui,WANG Luhuan,LI Liying,SHI Liping,ZHANG Kai.Research Laboratory of Biochemistry,Institute of Basic Medicine,General Hospital of PLA, Beijing 100853;The role and mechanism of interleukin-1β and its receptor antagonist in lung injury induced by gut ischemia-reperfusion[J];Chinese Critical Care Medicine;2001-12
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Yang Lan Hao Weidong Shang Lanqin et al (Department of Toxicology, College of Public Health, Peking University);Protective Effect of Aqueous Extract of SiniTang on Injuried Cardiac Muscle Cell Induced by Hypoxia- Reoxygenation[J];China Journal of Traditional Chinese Medicine and Pharmacy;2005-06
2 WU Wei-kang, HUANG He-qing, TAN Hong-mei, LUO Han-chuan, LIANG Tian-wen (Institute of Integrated Traditional Chinese and Western Medicine, Sun Yat-sen University of Medical Sciences, Guangzhou 510089, China);The effect of Sini Tang on lipid metabolism and vascular endothelial function in rabbit with experimental atherosclerosis[J];JOURNAL OF FIRST MILITARY MEDICAL UNIVERSITY;2000-02
3 LEI Bo,DU Peng,CHEN Yong (Hubei Province Key Laboratory of Biotechnology of TCM,Hubei University,Wuhan 430062,China);Elementary study on the rule of mating Aconitum Carmichaili and mating drugs[J];Journal of Hubei University(Natural Science);2007-03
4 GUO Suzhong(The People's Hospital of Xiangtai city Hebei province,Xingtai 054001);Application of phubarb on emergency of acute organophoshours pesticide poisoning.[J];Attend to Practice and Research;2009-12
5 Huang Wenfeng, Hu hanbo. Tongji Medical College, Huazhong University of Science Techology, Wuhan 430030;Effect of large dose of indomethacin on rat lung injury induced by aspiration of hydrochloric acid.[J];Central China Medical Journal;2004-02
6 GONG Jianquan1,BI Ningkang2,YUE Yinan2(Department of paediatrics,People's Hospital of Pingyin County,Shandong Jinan,);Serum Interleukin-1β Expression and Effect of Interleukin-1β on Pathologica Lchange of Lung in Rats with Renal Ischemia Reperfusion[J];Journal of Jining Medical College;2008-01
7 WU Wei-Kang, HEI Zi-Qing 1, SUN Hui-Lan, MEI Kai-Yong 2, and LUO Han-Chuan (Institute of Integrated Traditional Chinese and Western Medicine, Sun Yat-Sen College of Medical Sciences, Zhong Shan University, Guangzhou,Guangdong 510080, China; 1.The First Affiliated Hospital of Zhong Shan University; 2.The Department of Pathology, Sun Yat-Sen College of Medical Sciences);The Effects of Sini Decoction on Atherosclerosis and Oxidative Injury in Rabbits Fed with Cholesterol Rich Diet[J];Chinese Journal of Arterial Lerosis;2003-06
8 Qian Xiaoxian, Chen Yanming, Wu Weikang, et al (Department of Cardiology, The Third Affiliated Hospital of Sun Yatsen University of Medical Sciences, Guangzhou, 510630);Effect of Baoxin capsule on nitric oxide and endothelin in acute myocardial ischemia dogs[J];CHINESE JOURNAL OF CLINICAL PHARMACY;2000-05
9 JIANG Zhi-quan,CHEN Qian-fen, TIAN He-cun. Department of Neurosurgery, Affiliated of Bengbu Medical College , An hui 233004, China;Protective effect of SINI decoction on cerebral ischemia-reperfusion injury in mice[J];Chinese Journal of Cenebrovascular Diseases;2004-12
10 Zhang Chunyan,Chi Jinfeng,Zhan Yumin,et al;Effect of rushing down with rhubarb for the treatment of acute organophosphorus poisoning patients[J];Shandong Medical Journal;2004-05
China Proceedings of conference Full-text Database 1 Hits
1 Yang Lan Hao Weidong Shang Lanqin(Department of Toxicology,College of Public Health,Peking University);Protective Effect of Aqueous Extract of SiniTang on Injuried Cardiac Muscle Cell Induced by Hypoxia-Reoxygenation[A];[C];2005
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LI Hong1,ZHANG Chun-xiao2,ZHANG Wen-jie2, YANG Shi-jie 1 (1. Department of Pharmacology, School of Basic Medical Sciences, Jilin University, Changchun 130021,China; 2.Department of Physiology, School of Basic Medical Sciences, Jilin University, Changchun 130021,China);Effects of chemical H of Renshen Sini Tang on isolated working heart in guinea-pig[J];Journal of Jilin University of (Medicine Edition);2004-04
2 Yang Lan Hao Weidong Shang Lanqin et al (Department of Toxicology, College of Public Health, Peking University);Protective Effect of Aqueous Extract of SiniTang on Injuried Cardiac Muscle Cell Induced by Hypoxia- Reoxygenation[J];China Journal of Traditional Chinese Medicine and Pharmacy;2005-06
3 CHEN Shi-feng,JIANG Yue-quan,ZHU Bing(Department of Thoracocardiac Surgery,The Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010,China);An experimental study of the oxymatrine to attenuate the lung ischemia-reperfusion injury[J];Chongqing Medicine;2010-04
4 WU Wei-kang, HUANG He-qing, TAN Hong-mei, LUO Han-chuan, LIANG Tian-wen (Institute of Integrated Traditional Chinese and Western Medicine, Sun Yat-sen University of Medical Sciences, Guangzhou 510089, China);The effect of Sini Tang on lipid metabolism and vascular endothelial function in rabbit with experimental atherosclerosis[J];JOURNAL OF FIRST MILITARY MEDICAL UNIVERSITY;2000-02
5 LIU Yong1,2,QIAN Xiao-xian1-3,WU Wei-kang2,3,ZHOU Bin1,2,CHEN Lin1,2,LIU Jin-lai1,2 1Department of Cardiology,the Third Affiliated Hospital,Sun Yat-sun University,Guangzhou 510630,China;2Cardiovascular Institute,3Institute for Integrated Traditional Chinese and Western Medicine,Sun Yat-sun University,Guangzhou 510080,China;Effects of Sini decoction on vascular stenosis after iliac artery balloon injury and oxidative stress in rabbits[J];Journal of Southern Medical University;2006-11
6 Liu Wei ming,Gu Zhi cheng,Affiliated Children Hospital,College of Medical,Suzhou Universi ty,Suzhou215003 China);PROTECTIVE EFFECT OF N-ACETYLCYSTEINE ON HEPATIC DAMAGE INDUCED BY INTESTINAL ISCHEMIA REPERFUSION IN RATS[J];Journal of Hepatobiliary Surgery;2004-03
7 Shen Hong(The First Military Medical University,Guangzhou,510515);STUDY ON THE QUANTITATIVE METHOD OF IMMUNOHISTOCHEMISTRY(Ⅲ)[J];CHINESE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY;1995-01
8 GUO Jian-ji,WU Guo-yong,ZHONG Fo-tian,HE Wei.Department of Cardiac Surgery , the First Affiliated Hospital of Guangxi Medical University (Nanning 530021), China.;The protective effect and mechanism of Sini Decoction on cold preservation of donor heart[J];Guangxi Medical Journal;2005-06
9 Yu Zhui, Xu Youzhi, Zhou Xiaoyang, et al Department of Emergency, Zhongnan Hospital,Wuhan University,Wuhan 430071, China;Chronological Changes of iNOS mRNA and eNOS mRNA Expression in Rats' Acutely Injured Lungs[J];Journal of Hubei Medical University;2003-01
10 HUANG Liang,ZHANG Yali,ZHANG Xiaofen,et al.Postgraduate of Guiyang Traditional Chinese Medicine College,Guiyang 550002;Effection of Sini decoction on serum Endothelin and Calcitonin gene-related peptide in congestive heart failure rat model[J];Hebei Journal of Traditional Chinese Medicine;2006-01
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 LIU Ke-xuan,HUANG Wen-qi;Protective effects of preconditioning and postconditioning against the intestines I/R injury[J];China Continuing Medical Education;2010-04
2 Liu Xiaoai1,Zeng Ping2,Wu Weikang3 et al1Department of Physiology,Guangzhou Medical University,Guangzhou 5101822Pediatric Intensive Care Unit,Guangzhou Children's Hospital,Guangzhou 5101203Department of Pathophysiology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080;Effect of Sini Decoction on Inflammatory Mediators and Oxidative Stress of Rats with Multiple Organ Dysfunction Syndrome[J];Acta Medicinae Universitatis Scientiae et Technologiae Huazhong;2009-04
3 TAN Guang-guo1,ZHU Zhen-yu1,LI Xiang2,ZHAO Liang3,ZHANG Hai3,LIU Yi1,CHAI Yi-feng1(1.Department of Pharmaceutical Analysis,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;2.Center of Disease Prevention and Control,Beijing Military Region,Beijing 100042,China;3.Department of Pharmacy,Eastern Hepatobiliary Hospital,Second Military Medical University,Shanghai 200433,China);Analysis on chemical constituents of Sini decoction by RRLC-TOF/MS[J];Journal of Pharmaceutical Practice;2009-04
4 GAO Zhi-xiang,JIANG Xiao-han,WANG Yan,WANG Lin,JIANG Zhi-ming,MENG Fan-hao (1.Department of medicinal Chemistry,School of Pharmaceutical Science,China Medical University,Shenyang 110001,China;2.Guangdong Food and Drug Vocational and Technical Schools,Guangzhou 510663,China;3.Shenyang military General Hospital Medical Laboratory Science,Shenyang 110005,China);Simultaneous Quantification of three active compounds in Sini Tang by HPLC[J];Journal of China Medical University;2011-07
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 Yan Guangtao\ Hao Xiuhau\ Wang Luhuan et al. (Res.Laboratory of Biochemistry,Basic Medical Institute,General Hospital of PLA,Beijing\ 100853);The Establish and Primary Application of Specific Interleukin\|1β Radioimmunoassay in Serum[J];PROGRESS IN BIOTECHNOLOGY;1999-06
2 Yan Guangtao,Xin Hong,Wang Luhuan,et al;Phospholipase A 2 activation mediates acute lung injury following intestinal ischemiareperfusion[J];CHINESE CRITICAL CARE MEDICINE;1997-10
3 Wang Luhuan,Xin Hong,Yan Guangtao.Research laboratory of Biochemistry,Institute of Basic Medicine,The General Hospital of PLA,Beijing 100853;Role of intestinal ischemiareperfusion injury induced by phospholipase A 2 activation[J];CHINESE CRITICAL CARE MEDICINE;1998-08
4 Wu Wei-kang;Hou Can;Luo Han-chuan;et al(Sun Yat-sen University of Medical Sciences,Guangzhou 510089);Mechanisms Responsible for Protective Effect of Sini Decoction on Ischemic Myocardium in Mice[J];CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE;1994-09
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved