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《Chinese Journal of Anesthesiology》 2006-08
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Effects of sevoflurane on endotoxin-induced oxidative stress response of the lungs in rats

SUN Yan-hong (?) Yong WANG Jun-ke Department of Anes(?)siology,Frist Affi(?) (?) of (?) Medical University,Shenyang 110001,China  
Objective To investigate the effects of sevoflurane on oxygen free radical and NO metabolism in the lungs induced by endotoxin.Methods Forty-eight Wistar rats of both sexes weighing 200-290 g were randomly divided into 4 groups (n=12 each):groupⅠcontrol;groupⅡLPS 5 mg·kg~(-1);groupⅢLPS 5 mg·kg~(-1)+1.0 MAC sevoflurane and groupⅣLPS 5 mg·kg~(-1)+1.5 MAC sevoflurane.The animals were anesthetized with intraperitoneal (IP) pentobarbital sodium 100 mg·kg~(-1),tracheostomized and mechanically ventilated.P_(ET) CO_2 was maintained at 35-45 mm Hg.Right carotid artery and left femoral vein were carmulated for BP monitoring and fluid and drug administration.In control group normal saline 1.2 ml was givenⅣ.In LPS group LPS 5 mg·kg~(-1) was givenⅣ.In groupⅢandⅣsevoflurane was inhaled after LPSⅣ.The animals were killed by blood-letting after 4 h mechanical ventilation.The lungs were immediately removed for determination of SOD,MDA,NO,tNOS content and iNOS,iNOS mRNA and protein expression in the lungs.Results The lung content of SOD was significantly decreased while MDA,NO,tNOS content and iNOS mRNA and protein expression in the lungs were significantly decreased as compared with control group.Inhalation of 1.0 or 1.5 MAC sevoflurane attenuated the changes induced by LPS.Conclusion 4 h sevoflurane inhalation can attenuate the oxidative stress response of the lungs to LPS-induced.
【CateGory Index】: R614
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