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《Chinese Journal of Endocrinology and Metabolism》 1989-01
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CHARACTERISTICS OF SUBJECTS WITH IGT AND ITS CORRELATION WITH CORONARY HEART DISEASE

Pan Xiao-ren Department of Endocrinology, China-Japan Friendship Hospital, Beijing  
Among 280,000 population aged 25-74 years in Da Qing, 108, 600 persons were surveyed for diabetes in 1 986. According to WHO criteria (1980), 596 (5.5‰) persons with impaired glucose tolerance (IGT) and 630 (5.8‰) new diabetics were diagnosed in addition to 190(1.7‰) diabetics known. In comparison to age-sex-matched controls with normal oral glucose tolerance test, hypertension(35.3%), obesity (BM1≥25, 61%) and rate of microalbuminurea excretion were twice as common in IGT as in controls. The prevalence of hyperlipoproteinemia were higher in IGT than that in controls, IGT had a prevalence of coronary heart disease 8.9 times greater than did controls. Although IGT had hyperinsulinemia, one-hour IRI (insulin mU/L: blood glucose mmol/L) after 75g glucose load were lower in IGT than that in controls. Therefore IGT had both insulin resistance and impaired function of islet. Non-symptomatic slight hyperglycemic state itself in IGT was a risk factor for CHD, which was independent of age, hyperlipoproteinemia, hypertension and obesity.
【Key Words】： Impaired glucose tolerance Coronary heart disease
【DOI】： CNKI:SUN:ZHNF.0.1989-01-006
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