Disturbance of gastric motility in patients with diabetes mellitus and the therapeutic effect of gastrokinetic agent
LU Guang-hua, TENG Xiang-yv, REN Ying, FAN Wu-qiang, ZHOU Huan, LIU Wei. Department of Endocrinology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001
Objective To study gastric motility in patients with type 2 diabetes mellitus (DM) and to observe the therapeutic effect of cisapride on diabetic gastroparesis. Methods The gastric half emptying time (CET1/2) of liquid and solid meals radiolabelled with 113mIn and 99mTc respectively were determined by SPECT imaging technique and electrogastrogram (ECC) was performed in 74 patients with type 2 DM. Fasting blood glucose (FBG) was simultaneously measured. Results (1) None of the 22 diabetic patients with FBG 7.8 mmol/L showed delayed GET1/2; while among 52 diabetic patients with FBG 7.8 mmol/L, 36 patients (69.2%) had delayed solid phase GET1/2 , and among them 14 patients were accompanied with liquid phase GET1/2 delay (P0.01).(2) There was no significant difference in fasting and postprandial principle frequency, average over-zero frequency between the normal control group and the DM group. Postprandial amplitude was significantly higher than fasting amplitude in the two groups (P0.05).The arrhythmia rate in the DM group was significantly higher than that of the normal control gruop (P 0.05 ).(3) The radiolabelled gastric emptying (RGE) was related with ECG manifestations when FBG was more than 7. 8 mmol/L. (4) Thirty-six diabetic patients with gastroparesis were divided into 2 groups. Group A was treated with hypoglycemic drugs and cispride while group B with hypoglycemic drugs alone for 4 weeks. Improvement was noted in 85% of the cases in group A, but none in group B. Conclusion (1) In DM patients, there is an inverse relationship between gastric empting and FBG, relationship does exist between RCE and ECG when blood glucose level is controlled poorly. (2) Cisapride shows a favorable effect on diabetic gastroparesis.
【CateGory Index】： R587.1