Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM》 1998-05
Add to Favorite Get Latest Update

Physiological variation of androgens and 5α reductase activities in male foreskin at different development stage

Cui Yugui,Zhang Guiyuan.Department of Endocrinology,the First Affiliated Hospital of Nanjing Medical University,Nanjing,210029  
Objective To study the physiological variation, as well as its significance, of androgens and 5α reductase activities in male individuals at different development stage. Methods The foreskins were acquried from 58 subjects, aged 9 months to 34 years. Testosterone (T) and dihydrotestosterone (DHT) levels in these target tissues were measured by radioimmunoassay after homogenization, and the activities of 5α reductase isozyme I and II by the methods developed in our laboratory. Results The levels of T and DHT, and the activities of 5α reductase isozymes in target tissues remained low in children from 2 to 5 years of age. After 6 years of age these values would rise during the stages of pubertal development and reach new peaks at age of 14 to 16 years. After completion of pubertal development, 5α reductase and its catalyzing product DHT, as well as T itself, tended to keep at more stable and high levels. Conclusion ①5α reductase II activities are androgen dependent. ②Just as T itself, 5α reductase and DHT play important roles in male pubertal development and in maintenance of male sexual features.
【Key Words】: Testosterone Dihydrotestosterone 5α reductase Sex differentiation and development
【CateGory Index】: R335.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 CUI Yugui1, FU Guangbo2, ZHANG Guiyuan3, QIAN Lixin4, DI Fusong5. 1 Center of Clinical Reproductive Medicine, 4 Department of Urology, and 5 Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; 2 Department of Urology, The Affiliated Huaian First People's Hospital of Nanjing Medical University, Huaian 214002, China; 3 National Research Institute for Family Planning, Beijing 100081, China Corresponding author: CUI Yugui, E-mail: cuiygnj@njmu.ed.com;Physiological Variation of Androgen Levels (T and DHT) in Target Tissues at Different Developmental Stages of Male[J];Journal of International Reproductive Health/Family Planning;2009-01
2 CUI Yu-gui,HUA Li-xin,WANG Xing-hai,MA Ding-zhi,JIA Yue,CAI Rui-fen,TONG Jian-sun,YANG Ming-de,GAO Li. Reproductive Medicine Center of the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China (CUI Yu-gui,JIA Yue,YANG Ming-de,GAO Li); Urological Department of the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China (HUA Li-xin); Jiangsu Provincial Institute for Family Planning,Nanjing 210036,China (WANG Xing-hai,MA Ding-zhi,CAI Rui-fen,TONG Jian-sun);Study on the Androgen Level and 5α-reductase Activity in Prostate Tissues of Dogs With Benign Prostatic Hyperplasia[J];Journal of International Reproductive Health/Family Planning;2009-05
3 Yu-Gui CUI1, Gui-Yuan ZHANG2 (1. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China; 2. National Research Institute of Family Planning, Beijing 100081, China);Steroid 5α-Reductase Activity, Androgen Level and Its Receptor in the Target Tissues of Male Fetuses[J];Acto andrologica Sinica;2001-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Wang Pu 1,2 ,Chen Xiyang 2,Yu Bingjun 2,Cen Peilin 1 (1 Institute of Biochemical Engineering,Zhejiang University,Hangzhou,310027; 2 College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou,310032 );Applications of New Techniques on Steroid Synthesis by Microbial Transformation[J];Chemical Industry and Engineering Progress;2002-11
2 Rui Fen CAI 1 , Yu Gui CUI 2 , Li Xin HUA 2 , Yue JIA 2 , Ding Zhi MA 1 , Xing Hai WANG 1 (1.Jiangsu Family Planning Institute, Nanjing, Jiangsu 210036, China; 2.Key Laboratory, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China);Experimental Research on Spontaneous Benign Prostatic Hyperplasia in Old Dogs[J];Acto andrologica Sinica;2003-09
3 CUI Yugui,ZHANG Guiyuan Department of Reproductive Endocrinology,National Research Institute for Family Planning,Beijing 100081;The steroid 5a-reductase isozyme activities in foreskin of Chinese adult men[J];JOURNAL OF REPRODUCTIVE MEDICINE;1995-01
4 CUI YuGui,ZHANG GuiYuan,LI Yian,YU Qi,He Fangfang,TIAN Qinjie,GE Qinsheng De partment of Reproductice Endocrinology,National Research Institute for Family Planning, Beijing 100081 *Peking Union Medical College Hospilal;Study on the cytosol and nuclear androgen receptor of normal male adults and patients with androgen insensitivity syndrome[J];JOURNAL OF REPRODUCTIVE MEDICINE;1995-04
5 HAN Guang-Dian;HUANG Guo-Feng, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing;Exploitation of Sterol Resources and Synthetic Methods for the Corticoid Side Chain[J];Chinese Journal of Organic cHEMISTRY;1989-01
6 XIANG Wei *, ZHAO Shuiping, ZHANG Baolin, et al * The Second Affiliated Hospital of Hunan Medical University, Changsha 410011;Apolipoprotein E polymorphism and plasma lipid, lipoprotein, apolipoprotein levels in children with the simple obesity[J];Chinexe Journal of Pediatrics;1999-08
7 Gao Yan-ling;Wang De-fen;Zeng Ji-sheng;et al.(Ruijin Hospital Affiliated to Shanghai SecondMedical University,Shanghai 200025.);A STUDY ON CORRELATION BETWEEN21-HYDROXYLASE GENE DEFECTS ANDCLINICAL TYPES BY USING PCR-ASO TECH-NIQUE[J];Chinexe Journal of Pediatrics;1994-02
8 Li Zholr-suan;Feng Ze-kang; Hiao Xin; et al. (Affiliated Hospitof,fian University Medical College, Guangzhou 510632.);TRIIOOOTHYRONINE, THYROXINE, THYROIDSTIMULATING HORMONE, INSULIN, CORTISOL AND HUMAN GROWTH HORMONECONCENTRATIONS IN CORD SERUM OFPRETERM AND TERM SMALL FORGESTATIONAL AGE INFANTS[J];Chinexe Journal of Pediatrics;1994-05
9 Meng Xunwu; Zhao Weigang; TanShuwen; et al.(PUMC Hospital, CAMS andPUMC, Beijing 100730.);CLINICAL ANALYSIS OF 13 CHILDRENWITH PRIMARY HYPERPARATHYROID-ISM[J];Chinexe Journal of Pediatrics;1995-02
10 Fang Junmin, Zhu Minghua, Li Chunlei, et al. Department of Pediatrics, Tongji Hospital, Tongji Medical University, Wuhan 430030;Investigation on diagnostic procedure for chronic lymphocytic thryoiditis in children[J];Chinexe Journal of Pediatrics;1997-05
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 Hong Jun WANG 1 , Jia Ying ZHANG 2 , Su Huan LIU 1 , Hui ZHAO 1 , Zhong Shan WANG 1 (1 Department of Cell Biology, 2 the Second General Laboratory, School of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, China);Changes of 5 Alpha-reductase Type Ⅱ Activity in Sexual Gland of Diabetic Male Rats[J];Acto andrologica Sinica;2003-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved