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《Chinese Journal of Internal Medicine》 2002-02
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Expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in IgA nephropathy

WANG Jianzhong, CHEN Xiangmei, SHI Suozhu, ZHANG Yanping, TIAN Yue. Division of Nephrology, General Hospital of PLA, Kidney Center and Key Laboratory of PLA, Beijing 100853,China  
Objective To explore the expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the renal tissue of patients with IgA nephropathy. Methods Immunohistochemistry and in situ hybridization assays were applied to detect the expression of mRNA and protein of TIMP-1, as well as the protein expression of MMP-9 in renal tissue of 38 patients with IgA nephropathy. Results MMP-9 was normally expressed, at a low level, in the glomerular endothelial cells and visceral epithelial cells, as well as in tubular epithelial cells and walls of vessels. The expression of MMP-9 was significantly increased in mesangial proliferative glomeruli and interstitial vascular walls of IgA nephropathy patients (P0.001), but markedly decreased in sclerotic glomeruli and not apparently altered in the tubule. No expression of TIMP-1 could be detected in normal renal tissue. TIMP-1 was only slightly expressed in the mesangioproliferative glomeruli of IgA nephropathy patients. TIMP-1 expression was increased notably in partially sclerotic glomeruli, and most prominently expressed in tubulointerstitium (P 0.01), mainly in tubular epithelial cells, interstitial cells, and vascular endothelial cells. The expression of TIMP-1 was distinctly associated with the level of serum creatinine (P0.05), tubulointerstitial fibrosis (P0.01), and tubulointerstitial infiltration of leukocytes (P0.01). MMP-9 expression did not correlate with proteinuria, but negatively correlated with serum creatinine levels (P0.05). Conclusion The abnormal expressions of MMP-9 and TIMP-1 may contribute to the progression of IgA nephropathy.
【Fund】: 国家重点基础研究发展规划“973”项目 (G2 0 0 0 0 5 70 0 3)
【CateGory Index】: R692
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