BASELINE HYPERTRIGLYCERIDEMIA, A RISK FACTOR FOR NON-INSULIN DEPENDENT DIA-BETES MELLITUS: A 6-YEAR FOLLOW-UP STUDY OF 432 NONDIABETICS

Yang Wenying;Xing Xiaoyan;Lin Hong, et al (Department of Endocrinology,China-Japan Friendship Hospital, Beijing 100029)  

he relationship between baseline fasting plasma triglycerides level (FTG) and the incidence of non-insulin-dependent diabetes mellitus (NIDDM)within 6 years were investigated in 432 Chinese nondiabet-ics. They were identified by oral glucose tolerance test(OGTT,oral 75 g glucose) in Daqing diabetes sur-vey in 1986. 220 subjects were men and 212 women, Among them 226 had normal glucose tolerance and 206 impaired glucose tolerance. The measurement of fasting plasma lipids and glucose were performed at the baseline examination and after 6-year follow-up. Six-year incidence of NIDDM in the highest triglyc-erides tertile group (top tertile Q_3,mmol/L) was 2. 3 times(38.6%vs 16.6%,P0. 01) as com-pared with that of the lowest triglycerides tertile group(first tertile Q_几 mmol/l), The difference of 2-hour blood glucase level in OGTT(OGTT BG2h level)between Q_1 and Q_3 was 2. 4mmol/L (～10. 0mmol/L) after 6 years. Multivariate general linear regression analysis demonstrated that the FTG level was positively associated with the OGTT BG2h level after 6 years (P=0. 0335) after controlling the age, sex, fasting blcod glucose (FBG)and body mass index(BMI); Therefore this result indicates that FTG level is an independent risk factor for the development of NIDDM in this population.

【Key Words】： Triglycerides Diahetes mellitus
【CateGory Index】： R587.1
【DOI】： CNKI:SUN:ZHNK.0.1995-09-002

Download(CAJ format) Download(PDF format)

CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.