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《CHINESE JOURNAL OF PHARMACEUTICALS》 1999-12
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HPLC DETERMINATION FOR DISSOLUTION OF GALANTAMINE HYDROBROMIDE CAPSULES

YAN Jin, WANG Ming Xin , CHEN Yun Lei, MA Guang En (National Institutes of Pharmaceutical Research and Development, Beijing 102206)  
A HPLC method was established for the determination of dissolution of galantamine hydrobromide capsules,using a μBondapak Phenyl column and methanol phosphate buffer (10∶90) as mobile phase, with the flow rate of 1.0ml/min and 289nm as detective wavelength. The standard curve was linear within the range of 5~25μg/ml. The reco very was over 98%. The intra day and inter day RSD were 1.34% and 0.62%, respectively. This method was more simple, accurate and reproducible than spectrophotometry.
【Key Words】: galantamine hydrobromide HPLC dissolution determination capsules
【CateGory Index】: R927.2
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