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Study on Sustained Release Insulin Nanocapsules for Injection

YIN Zong Ning *, LU Bin (School of Pharmacy, West China University of Medical Sciences, Chengdu 610041)  
The sustained release insulin nanocapsules (INS NC) were prepared by emulsifying polymerzation method, using biodegradable polybutylcyanoacrylate as the carrier. The entrapment ratio of INS NC was 93.75% with an average diameter of 101 nm and span value of 1.14. The lyophilized INS NC for injection showed little change in content, entrapment ratio and average diameter after storage at 4℃ and 15~25℃ for three months. The release in vitro of insulin from INS NC for injection could be described by double exponential equation. After a single subcutaneous injection of encapsulated insulin, the blood sugar in diabetic rats was decreased and this effect was maintained for 7 d. The dependence of effect on dose was obvious at absorption phase. The efficacy of INS NC for injection was significantly better than insulin injection of the same dose ( P0.05 ).
【Fund】: 高等学校博士点专项基金资助课题!(950413)
【CateGory Index】: R917
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