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《Chinese Journal of Pharmaceuticals》 2005-03
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Preparation and Transdermal Absorption of Indomethacin Microemulsion

LIAN Yun-Fei, LI Juan*, PING Qi-Neng, YAN Fei(Dept. of Pharmaceutics,China Pharmaceutical University, Nanjing 210009)  
The system of microemulsion consisted of oleic acid, Cremorphor Rh60, Labrasol and water. Pseudoternarycomposition diagrams were drawn to confirm the area of o/w microemulsion, and to select the optimum formulation ofindomethacin microemulsion. The effects of five permeation enhancers on the penetration of indomethacin bulk drug andmicroemulsion were evaluated, respectively. The results showed that the area of o/w microemulsion reached a maximumat Cremorphor RH60-Labrasol (1∶2). The optimum permeation enhancer was azone, the penetration rate was (73.52±2.30)mgcm-2h-1 and the 24h cumulative amount reached 1700mg/cm2 when the microemulsion containing 5% azone.
【CateGory Index】: R943
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