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《Chinese Journal of Pharmaceuticals》 2006-01
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Preparation and Transdermal Permeation in Rabbits of Solid Lipid Nanoparticles Loaded with Retinoic Acid

LU Yang-Yan1,2, ZHOU Hua-Feng1,2, XIA Qiang1*, MA Quan-Hong1,2, GU Ning1(1. National Lab. of Molecular and Biomolecular Electronics, Jiangsu Lab. for Biomaterials and Biodevices, Dept. of Biological Scienceand Medical Engineering; 2. Dept. of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096)  
The preparation of solid lipid nanoparticles(SLN) of retinoic acid was optimized based on the phasediagram of drug-loading microemulsion at 60℃. Glyceryl monostearate was used as lipid carrier. The results showed that theoptimized ratio of carrier and emulsifiers —— polyoxyethylene (40) stearate-Poloxamer F-68(7∶3)was 1∶6 and theparticle size of retinoic acid SLN was slightly increased with the increasing of drug loading. The mean diameter of the productwith drug loading of 182μg/ml stored at 25℃ protected from light for 120d was (12.8±0.7)nm. The accumulative amount ofpermeation for 8h through the excised rabbit skin was significantly greater than that of retinoic acid cream.
【Fund】: 江苏省自然科学基金创新人才项目(BK2002404);; 江苏省发展计划委员会资助项目(7607038009)
【CateGory Index】: R94
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2 ZHOU Li-juan1,2,LIU Qing-fei1,CHEN Xi1,XU Mu3,WANG Yi-ming1,LUO Guo-an1(1 Institute of Biomedicine,Tsinghua University,Beijing 100084,China;2 Jiangxi University of TCM,Nanchang 330006,China;3 Zhuhai R&D Center for Novel Dosage Form of Biomedicine,Zhuhai 519085,China);Application status and development tendency of the pharmaceutical microemulsion[J];Chinese Journal of New Drugs;2007-22
Chinese Journal Full-text Database 2 Hits
1 LU,Yang-Yan~(1,2) XIA,Qiang~1 XIA,Yong~1 MA,Quan-Hong~(1,2) GU,Ning~1~1Research Center for Nano-scale Science and Technology,Key Laboratory of Molecular and Biomolecular Electronics,Ministry of Education,Southeast University;~2Department of Chemistry and Chemical Engineering,Southeast University,Nanjing 210096;Studies on the Phase Behaviors of Drug-loading Microemulsions[J];Acta Physico-chimica Sinica;2005-01
2 QIAO Wei, TIAN Yi hong (College of Pharmacy, Tianjin Medical University, Tianjin 300203, China);Percutaneous Experiment of Bufalin in Vitro[J];CHINESE TRADITIONAL PATENT MEDICINE;2000-10
Chinese Journal Full-text Database 10 Hits
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2 LIAN Jia-Fang 1,2 ,ZHANG San-Qi1,GU Yi1,SHI Xiao-Peng1,XI Miao-Miao1 1Department of Pharmacy,Xijing Hospital,Xi'an 710033, China, 2Bethune Military Medical College, Shijiazhuang 050081, China, Fourth Military Medical University;Preparation of floxuridine diacetate solid lipid nanoparticles[J];Journal of the Fourth Military Medical University;2006-03
3 LIU Yu, LU Fu-Sui*, CHEN Tian-Tian, GAO Cui-Li, ZHU Heng-Ying, ZHAO Hui(College of Chemistry and Materials Science, Shandong Agricultural University, Tai′an 271018, China);Studies on the Effect of Different Coherer Counter-ions on Forming Rule and Stability of Cyhalothrin Microemulsion[J];Chemical Journal of Chinese Universities;2007-05
4 CHEN Dan1,LU He-ping2(1.Pratacultural College,Gansu Agriculture University,Lanzhou Gansu 730070,China;2.Institute of Plant Protection,Gansu Academy of Agricultural Science,Lanzhou Gansu 730070,China);Screening Pesticide of Beta-Cypermethrin Emulsion in Water Using the Pseudo-ternary Phase Diagram[J];Gansu Agricultural Science and Technology;2008-07
5 ZHANG Xiao-jia1, XIA Qiang1, MA Quan-hong1,2, DUAN Lei1, GU Ning1 (1. Key Lab. Mol. Biomol. Electr., Ministry of Education, Res. Cent. Nano-scale Sci. & Technol., Southeast Univ., Nanjing, Jiangsu 210096, China; 2. Dept. Chem. Chem. Eng., Southeast Univ., Nanjing, Jiangsu 210096, China);Preparation of Nanostructured Lipid Carriers Loaded with Retinoic Acid by the High Pressure Homogenization Method[J];The Chinese Journal of Process Engineering;2005-01
6 ZHOU Hua-feng1,2,MA Quan-hong1,2,DING Yi2,XIA Qiang1,KUANG Ying-zi2,HAO Xiao-zhen2,GU Ning1(1.Jiangsu Lab.Biomater.& Biodevice,National Lab.Bioelectronics,Southeast Univ.,Nanjing,Jiangsu 210096,China;2.Department of Chemistry and Chemical Engineering,Southeast University,Nanjing,Jiangsu 210096,China);Controllable Preparation and Characterization of Imiquimod-loaded Nanostructured Lipid Carriers[J];The Chinese Journal of Process Engineering;2006-04
7 XU Yuan-long,LI Xue-ming~*,LIN Sheng-zhao,CHEN Guo-guang(College of Life Science and Pharmaceutical Engineering,Nanjing University of Technology,Nanjing 210009,China);Preparation of solid lipid nanoparticles containing the Zedoary turmeric oil[J];West China Journal of Pharmaceutical Sciences;2005-06
8 LI Chen-rui1,JIANG Xue-hua1,YUAN Mu2,REN Jing1,TAN Fei1(1.West China School of Pharmacy,Sichuan University,Chengdu 610041,China;2.Guangzhou Medical School,Guangzhou 510182,China);Preparation of puerarin solid lipid nanoparticles for oral administration[J];West China Journal of Pharmaceutical Sciences;2007-04
9 SUN Xue-Hui~ ②④ ,GUO Tao,HE Jin,SONG Hong-Tao~③,NIE Shu-Fang (~②Department of Pharmacy,the General Hospital of Shenyang Military Region,Shenyang 110016,Liaoning China) (~③Department of Pharmacy,General Hospital of Fuzhou Military Region,Fuzhou 350025,Fujian China) (~④Shenyang Pharmaceutieal liniversity,Shenyang 110016,Liaoning China);Preparation of Solid Lipid Nanoparticles Containing Garlic Oil[J];Pharmaceutical Journal of Chinese People's Liberation Army;2006-05
10 FAN Wei (Institute of Material and Chemical Engineering,Changchun University of Science & Technology, Changchun 130022, China);Organic Nano-Scale Pharmaceutical Carrier[J];;2003-04
Chinese Journal Full-text Database 10 Hits
1 LIU Jian,HAN Ming xiang,ZHANG Wan dong,CHEN Guang liang,LEI Li (The First Hospital Affiliated to Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China);INFLUENCE OF XINFENG CAPSULE ON SERUM LEVEL OF IL-1, TNFα,IL-4,AND IL-10 IN ADJUVANT ARTHRITIS RATS[J];Journal of Anhui Traditional Chinese Medical College;2002-02
2 ZHOU You xin*, HUANG Yu lun,XU Qi nian,YE Ming, SUN Cheng fa, ZHOU DaiDepartment of Neurosurgery,The First Affiliated Hospital of Suzhou University,Suzhou,215006,P.R.China;Several Monomes from Tripterygium Wilfordii Inhibit Proliferation of Glioma Cells In Vitro[J];Chinese Journal of Cancer;2002-10
3 Zhang Xingyi,Sun Mei,Wang Rongyou (The Department of Thoracic and Cardiovascular Surgery,The Second Clinical College,NBUMS,Changchun 130041,China);Effect of tripterygium wilfordii on immune injury coronary artery atherosclerosis in rabbit cardiac allografts[J];JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE;2000-01
4 Slang Shuchuan; Geng Yumin Hao; Jingcheng Hu Jiye(Department of Chemistry,Shandong Normal University,Jinan, 250014);Study on the Lyotropic Liquid Crystals[J];CHINA SURFACTANT DETERGENT & COSMETICS;1998-02
5 WANG Gang~1,FU Jing-guo~2,WANG Yu-dong~1,ZHENG Li-qiang~3,WANG Jiu-cheng~2,CHEN Tao~2(1.Department of Materials Science and Engineering,Zhengzhou University,Zhengzhou 450052,China;2.Xi'an Libang Pharmaceutical Technology Co.Ltd.,Xi'an 710075,China;3.Key Laboratory of Colloid and Interface Chemistry,Shandong University,Jinan 250100,China);Preparation of O/W microemulsion and measurement of skin irritation of microemulsion[J];China Surfactant Detergent & Cosmetics;2006-05
6 FENG Guangfeng, LI Hansheng(School of Chemical Engineering and the Environment, Beijing Institute of Technology, Beijing 100081);Study on Synthesis of CoFe2O4 Nanoparticles by Double Microemulsion and Their Magnetic Properties[J];Materials Review;2007-S1
7 BAO Yi-Xiao1, ZHANG Lu-Ding1, LI Li2, HAN Lian-Shu1, KONG Xian-Tao2 (1. Department of Pediatrics,Changzheng Hospital,Second Military Medical University,Shanghai 200003, China; 2. Department of Clinical Laboratory,Changzheng Hospital);Effect of tripterine on expression of bcl-2 family, c-myc and ICE gene in HMC-1 cells[J];Academic Journal of Second Military Medical University;2001-09
8 XU Xiao-Lian,GAO Liu-Min,LEI Jun-Rong Department of Pharmacy, Shaanxi Hospital of Armed-police , Xi'an 710054, China;Clinic observation : Levofloxacin hydrochloride injection is used to cure bacterial catch[J];Journal of The Fourth Military Medical University;2002-S1
9 ZHU Xiao-liang, CHEN Zhi-liang, LI Guo-feng, ZENG Kang Department of Dermatology, Institute of Pharmaceutical Sciences, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;Preparation and electron microscopic observation of lidocaine microemulsion[J];Journal of Southern Medical University;2006-04
10 LIN Feng-qiang~1,HU Song-hua~2 ,HU Qi-lin~1,CHEN Shao-ying~1 (1.Institute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agriculture Sciences,Fuzhou,Fujian,350003,China; 2.Zhejiang University , College of Animal Science,Hangzhou,Zhejiang,310029,China);The Adjuvant of Staphylococcus aureus Mastitis Bacterin in Dairy cows[J];Progress In Veterinary Medicine;2004-06
【Secondary References】
Chinese Journal Full-text Database 5 Hits
1 Zhang Shangpeng People Hospitol of Dongyang City,Zhejiang Province(322100);Study on the Prescription of Compound Microemulsion of Brucea Javanica Oil[J];Journal of Zhejiang University of Traditional Chinese Medicine;2010-02
2 Li Yong,et al Pharmacy school of Harbin(Harbin 150076);Advance on Nanostructured Iipid Carriers[J];Heilongjiang Medicine Journal;2009-06
3 Zhou Lijuan1,2,Liu Qingfei1,Chen Xi1,Wang Yiming1 and Luo Guoan1(1Institute of Biomedicine,Tsinghua University,Beijing 100084; 2Jiangxi University of TCM);Research on Entrapment Efficiency and Release Characteristics of Nimodipine Microemulsion in Vitro[J];Chinese Pharmaceutical Affairs;2008-07
4 KAI Wei-hua1,GUI Shuang-ying1,2,3,PANG Dai-yin2,WANG Jun3(1 Department of Pharmacy,Anhui TCM,Hefei 230031,China;2 "115" Innovative Team of Anhui province,Hefei 230031;3 University of Science and Technology of China;Hefei 230027);Effect of performulation of microemulsion on transdermal absorption[J];Chinese Journal of New Drugs;2009-07
5 CAO Fahao1,OUYANG Wuqing 1,WANG Yanping2(1.College of Veterinary Medicine,Northwest Agricultural and Forestry University,Yangling 712100,China;2.Shangqiu Vocational and Technical College,Shangqiu 476000,China);Preparation of O/W ginseng saponins-based nanoemulsion and its amplified immune response[J];China Journal of Chinese Materia Medica;2010-04
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 PAN Qing yi,LU Qing,CHENG Zhi xuan,ZHANG Jian ping,DONG Xiao wen(Departemnt of Chemistry,School of Science,Shanghai University,Shanghai 200072,China);STUDY ON THE STABILIZING CONDITIONS OF W/O MICROEMULSION[J];Chemical Research and Application;2001-03
3 Zhang Wei,Liu Yulan,Xu Congyun,Gao E,Bao Wenfang;Research on the Active Analgesic Component of Venenum Bufonis[J];JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY;1998-04
4 Pang Guoxiang, et al Eye Research Center, and Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing;Treatment of Keratoconjunctivitis Sicca with Topical Retinoic Acid[J];Chinese Ophthalmic Research;1990-01
5 Yang Shicheng (Yang SC), Zhu Jiabi (Zhu JB) 1, Liang Bingwen (Liang BW) 2 and Yang Changzheng (Yang CZ) (College of Chemistry and Engineering, Nanjing University, Nanjing 210093; 1Zhongkun Pharmaceutical Research Institute, China Ph;STUDIES ON CAMPTOTHECIN SOLID LIPID NANOPARTICLES[J];ACTA PHARMACEUTICA SINICA;1999-02
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