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《Chinese Journal of Pharmaceuticals》 2006-01
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Preparation and Transdermal Permeation in Rabbits of Solid Lipid Nanoparticles Loaded with Retinoic Acid

LU Yang-Yan1,2, ZHOU Hua-Feng1,2, XIA Qiang1*, MA Quan-Hong1,2, GU Ning1(1. National Lab. of Molecular and Biomolecular Electronics, Jiangsu Lab. for Biomaterials and Biodevices, Dept. of Biological Scienceand Medical Engineering; 2. Dept. of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096)  
The preparation of solid lipid nanoparticles(SLN) of retinoic acid was optimized based on the phasediagram of drug-loading microemulsion at 60℃. Glyceryl monostearate was used as lipid carrier. The results showed that theoptimized ratio of carrier and emulsifiers —— polyoxyethylene (40) stearate-Poloxamer F-68(7∶3)was 1∶6 and theparticle size of retinoic acid SLN was slightly increased with the increasing of drug loading. The mean diameter of the productwith drug loading of 182μg/ml stored at 25℃ protected from light for 120d was (12.8±0.7)nm. The accumulative amount ofpermeation for 8h through the excised rabbit skin was significantly greater than that of retinoic acid cream.
【Fund】: 江苏省自然科学基金创新人才项目(BK2002404);; 江苏省发展计划委员会资助项目(7607038009)
【CateGory Index】: R94
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