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《Chinese Journal of Pharmaceuticals》 2006-03
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Preparation of 3-Dimethylamino-3-phenylpropanol

LIAO Xiang-Wei, WU Xiao-Feng, GE Da-Lun, CHENG Yong-Hao, WU Song* (Institute of Materia Medica, Chinese Academy of Medical Sciences and Perking Union Medical College, Beijing 100050)  
3-Dimethylamino-3-phenylpropanol was prepared from benzaldehyde and malonic acid by Knoevenagel reaction and reduction with NaBH4-I2 system to give 3-amino-3-phenylpropanol followed by Eschweiler-Clark reaction with an overall yield of 29% based on benzaldehyde.
【CateGory Index】: O625.34
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