Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Pharmaceuticals》 2006-03
Add to Favorite Get Latest Update

Preparation of 3-Dimethylamino-3-phenylpropanol

LIAO Xiang-Wei, WU Xiao-Feng, GE Da-Lun, CHENG Yong-Hao, WU Song* (Institute of Materia Medica, Chinese Academy of Medical Sciences and Perking Union Medical College, Beijing 100050)  
3-Dimethylamino-3-phenylpropanol was prepared from benzaldehyde and malonic acid by Knoevenagel reaction and reduction with NaBH4-I2 system to give 3-amino-3-phenylpropanol followed by Eschweiler-Clark reaction with an overall yield of 29% based on benzaldehyde.
【Key Words】: 3-dimethylamino-3-phenylpropanol dapoxetine intermediate synthesis
【CateGory Index】: O625.34
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 DAI Rong1,GU Shun-lin2,GU Fei2,WANG Yu-cheng3(1 Nanjing Maternity and Child Health Hospital,Nanjing 210004,China;2 Department of Chemistry,Xuzhou Normal University,Xuzhou 221004,China;3 Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China);Synthesis of dapoxetine hydrochloride[J];Chinese Journal of New Drugs;2008-24
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 YU Wen-bing1,ZHOU Hua *1 ,GONG Da-chun 1,2 ,WEI Ping1 (1.College of Life Science and Pharmacy,Nanjing University of Technology,Nanjing 210009,China;2.College of Chemistry and Life Science,Sanxia University,Yichang 443003,China);Synthesis of β-benzyloxycarbonyl-β-propiolactone[J];Chemical Reagents;2005-12
2 YAN Hong,XING Guang jian,HU Juan,HUANG Jun ying (Department of Chemistry and Environmental Engineering,Beijing Polytechnic University,Beijing 100022,China);BIOCATALYSTS IN ORGANIC SYNTHETIC CHEMISTRY[J];Chemical Research and Application;2000-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved