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《Chinese Journal of Pharmaceuticals》 2011-10
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Effect of Cordyceps sobolifera Mycelium on Chronic Renal Failure in Rats

XIE Wei,GUO Yuefang,SHENG Yuchen~* (Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry,Shanghai 200437)  
Two kinds of rat model of chronic renal failure were established by 5/6 nephrectomy and electric cauterization to investigate the protective effect of Cordyceps sobolifera mycelium(CSM).The results showed that three dosage groups(0.6,1.2 and 2.4 g/kg) of CSM significantly inhibited the increase of serum urea nitrogen(BUN) level and creatinine(CRE) level in 5/6 nephrectomy rats and the increase of serum CRE level in electric cauterization rats.It indicated that CSM could reduce the rate of progression of chronic renal failure.
【Fund】: 国家“重大新药创制”科技重大专项(2009ZX09301-007)
【CateGory Index】: R285.5
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