Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Pharmaceuticals》 2013-03
Add to Favorite Get Latest Update

Progress in Research of Structure,Function and Inhibitors of Mcl-1 Protein

SUN Feng'e,FANG Hao*(Dept. of Medicinal Chemistry,School of Pharmacy,Shandong University,Jinan 250012)  
Apoptosis is closely related to the occurrence of many human diseases.Excessive apoptosis causes neurodegenerative diseases,while insufficient apoptosis is related to the generation of cancers and other diseases.Nowadays,Bcl-2 family proteins are found to be important in apoptosis regulation and many inhibitors of Bcl-2 have been investigated.Recently,more and more researchers focus on the studies of Mcl-1,which is a member of Bcl-2 family proteins,due to its unique role in the apoptosis pathway.This paper summarizes the structure and function of Mcl-1,and the recent progress of Mcl-1 protein inhibitors as potential antitumor agents.
【Fund】: 国家自然科学基金(21172133);; 山东大学自主创新基金(2012JC003)资助
【CateGory Index】: R96
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved