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《Chineae Journal of Organ Transplantation》 2002-03
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Effect of high dose immunoglobulin on the panel reactive antibody

ZHANG Aimin *, ZHENG Junhua, Min Zhilian, et al. *Department of Urology, Changzheng Hospital, The Second Military Medical University , Shanghai 200003,China  
Objective To investigate the effect of high dose immunoglobulin on HLA specific alloantibodies in highly sensitized patients awaiting organ transplantation.Methods A suppressive experiment in vitro was performed on 15 highly sensitized patients awinting renal transplantation having higher level of HLA specific alloantibodies after addition of high dose immunoglobulins and of 5 patients received a suppressive experiment in vivo. The serum of patients were divided into two groups: one was diluted with equal volume of IVIG and the other was diluted with PBS. Four patients were administrated 0.5?g /(kg·week) for 4 weeks and one received infusion for 8 weeks in the same dose. Two patients resulted in HLA specific alloantibodies drop to 10% received kidney and pancreas kidney transplantation.Results In vitro experiment showed that the percentage of RPLT in the experimental group was lower than in control group. After high dose of infusion of IVIG, the patients resulted in a reduction in absolute HLA specific alloantibodies of 2% to 51% (mean decrease: 23%). Two patients underwent subsequent transplantation and no serious rejection occurred.Conclusion Intravenous injection of high dose of IVIG could reduce the level of HL Aspecific alloantibodies in some highly sensitized patients in a dose dependent manner.
【CateGory Index】: R617
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