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《Chinese Journal of Organ Transplantation》 2003-05
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The role of mycophenolate acid on HBV replication in vitro

WU Jian,XIE Hai-yang,JIANG Guo-ping,et al. Department of Hepatobiliary Surgery,The First Affiliated Hospital of Medical College, Zhejiang University,Hangzhou 310003, China  
Objective To study the effect of mycophenolate acid(MPA)on HBV replication and viral protein synthesis in vitro. Methods The 2.2.15 cells were treated with different concentrations of MPA(1-50?mg/L) for 12 days. HBsAg and HBeAg in supernatant were detected by ELISA and intracellular HBV DNA was analyzed by slot blot hybridization. Results MPA could suppress the expression of HBsAg and HBeAg. The higher concentration induced the lower expression of HBsAg and HBeAg. The suppression rate of HBsAg and HBeAg by MPA at the concentration of 50?mg/L was 24.05?% and 30.20?% respectively. The effect of MPA on HBV DNA was similar in HBsAg and HBeAg. HBV DNA was only 49?% of the controls at the concentration of 50?mg/L . Conclusion MPA can suppress the expression of HBsAg and HBeAg and replication of HBV DNA in the 2.2.15 cells in a dose-dependent manner.
【CateGory Index】: R965
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Chinese Journal Full-text Database 4 Hits
1 YU Li-xin, WANG Zhi-peng, FU Shao-jie, WANG Yi-bin, DU Chu-fu, XU Jian, DENG Wen-feng Department of Kidney Transplantation, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China;Hepatitis C virus infection and clinical outcome of kidney transplantation[J];Journal of First Military Medical University;2004-06
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3 XIA Wei-liang, XIE Hai-yang, SHEN Yan, WU Li-ming, ZHANG Feng, ZHENG Shu -sen. Department of Hepatobiliary Pancreatic Surgery, Key Laboratory of Combine d Multi-organ Transplantation, Ministry of Health, First Affiliated Hospital, Z hejiang University School of Medicine, Hangzhou 310003, China;Effects of ciclosporin and tacrolimus on rep lication of hepatitis B virus in vitro: a comparative study[J];National Medical Journal of China;2006-02
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1 PEI Fei △, ZHENG Jie (Department of Pathology, Peking University School of Basic Medical Sciences, Beijing 100083, China);A clinicopathologic analysis on 27 allograft biopsies in 10 patients following their orthotopic liver transplantation[J];Journal of Beijing Medical University;2002-03
2 YU Quan-sheng,ZHU Guang-hua,HE Wei-xun,FANG Ming-jun(Department of Nephrology,Children's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200040,China);Comparing the effects of mycophenolate mofetil and cyclophosphamide in the treatment of Henoch-Schonlein purpura nephritis accompanied by nephrotic syndrome[J];Journal of Clinical Pediatrics;2007-04
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5 QIU Shi, LIU Long, ZHAO Li ming, et al. Department of Urology, Shenyang General Hospital, Shenyang 110016,China;Neoral C_2 predicting drug hepatic toxicity following renal transplantation in hepatitis patients[J];Chinese Journal of Organ Transplantation;2003-01
【Secondary References】
Chinese Journal Full-text Database 10 Hits
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10 ;霉酚酸酯在治疗儿童肾脏病中的临床应用[J];Chinese Journal of Practical Pediatrics;2008-06
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