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《Chinese Journal of Organ Transplantation》 2003-05
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The role of mycophenolate acid on HBV replication in vitro

WU Jian,XIE Hai-yang,JIANG Guo-ping,et al. Department of Hepatobiliary Surgery,The First Affiliated Hospital of Medical College, Zhejiang University,Hangzhou 310003, China  
Objective To study the effect of mycophenolate acid(MPA)on HBV replication and viral protein synthesis in vitro. Methods The 2.2.15 cells were treated with different concentrations of MPA(1-50?mg/L) for 12 days. HBsAg and HBeAg in supernatant were detected by ELISA and intracellular HBV DNA was analyzed by slot blot hybridization. Results MPA could suppress the expression of HBsAg and HBeAg. The higher concentration induced the lower expression of HBsAg and HBeAg. The suppression rate of HBsAg and HBeAg by MPA at the concentration of 50?mg/L was 24.05?% and 30.20?% respectively. The effect of MPA on HBV DNA was similar in HBsAg and HBeAg. HBV DNA was only 49?% of the controls at the concentration of 50?mg/L . Conclusion MPA can suppress the expression of HBsAg and HBeAg and replication of HBV DNA in the 2.2.15 cells in a dose-dependent manner.
【Key Words】: Mycophenolate acid Hepatitis B virus Antigens Cell line
【CateGory Index】: R965
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