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《CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY》 1995-02
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The Effects of Sophora Flavescens Alkaloids (SFA) on Coxsackie Virus B3(CVB3)in Vitro and a Preliminary Study of Its Mechanism

Chen Fuxiang; Liu Jingxing; Lu Deyuan(Department of Microbiology, Shanghai Second Medical University, 200025)  
Sophora flavescens alkaloids (SFA) was extracted from sophora flavescens by acid percolation and chloroform extraction.The effects of SFA on Coxsackievirus B3 (CVB3) replication and capsid proteins were investigated in HeLa cell culture by SDS-PAGE and Western-blot. The results showed that SFA inhibited the CVB3 replication in vitro dose-dependently. Adding SFA before and after CVB3 was absorbed in and infected Hela cells. the similar inhibitory effects were observed. This suggested that both the absorption and penetration of CBV3 were unaffected by SFA and it could enter the cells and inhibitthe virus replication. Although the target of SFA activity remained to be elucidated, the Western-blot analysis of CVB3capsid showed that the biosynthesis of viral protein might be the site of inhibition.
【CateGory Index】: R373
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