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《CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY》 1998-03
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Expression of Bcl-2 and Bax proteins in liver tissues of chronic viral hepatitis

Xin Shaojie, Zhao Jingmin, Wang Songshan, et al. 302 Hospital of PLA,Beijing 100039  
In order to study the significance of expression of Bcl-1 and Bax proteins in the liver tissues, 35 cases of chronic viral hepatitis (CH) were immunohistochemically studied. The results showed that Bcl-2 and Bax were mainly co-located in cytoplasm of the mononuclear cells(MN) in the areas of focal necrosis, bridging necrosis and piecemeal necrosis(PN). Some hepatocytes surrounding these areas expressed Bcl-2 and Bax or expressed Bax only. Pathological examination found that these hepatocytes Suffered from hydropic or acidophilic degeneration. In the severe viral hepatitis, survival hepatocytes also expressed Bcl-2 and Bax. It is suggested that the expression of Bcl-2 and Bax in the liver tissues correlated with the apoptosis of hepatocytes in CH and influenced the progress of severe viral hepatitis.
【CateGory Index】: R512.6
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【Co-citations】
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