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《Chinese Journal of Experimental Surgery》 2001-06
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A study on the spleen Th1/Th2 cytokines immunological condition in the patients with primary hepatocellular carcinoma combined with liver cirrhosis

CAO Zhixin,CHEN Xiaoping,WU Zaide.Hepatic Surgery Center,Ton gji Hospital,Tongji Medical College,Huazhong University of Science and Technol ogy,Wuhan 430030,China  
Objective To study the spleen Th1/Th2 c yt okines expression pattern in the patients with primary hepatocellular carcinoma (PHC) combined with liver cirrhosis.Methods The patients with liver cirrhosis served as contr ol group.The expression levels of IFN-γ,IL-2,IL-10 in peripheral and splee n ven ous blood from 31 cases of PHC combined with liver cirrhosis were detected by EL ISA method.Results In the 6 patients with PHC of stage I,IL-2 leve l in peripheral venous blood and IFN-γ level in spleen venous blood were higher than in the liver cirrhosis group (P0.01 or P0.05),IL-10 levels in periph eral and spleen venous blood lower than in the liver cirrhosis group (P0.0 5).In the 12 patients with PHC of stage Ⅱ and 13 patients with PHC of stage Ⅲ ,the IFN-γ,IL-2 levels in peripheral and spleen venous blood were remarkabl y lower (P0.01 or P0.05) and IL-10 level were much higher than in t he liver cirrhosis group (P0.05).In addition,IFN-γ,IL-2 levels in spl een venous blood were lower and IL-10 level were higher than in peripheral veno us blood (P0.05).Conclusion The host immune system developed antitumor imm une response by the predominant secreation of Th1 type cytokine in the early PHC .The spleen play an important role in keeping the Th1/Th2 balance.As tumor advan ced,the host cellular immune function was impaired,the Th1 type cytokine level s were decreased and Th2 type cytokine levels were increased in advanced PHC.The host immunity was inhibited.The Th1/Th2 type cytokine of the spleen obviously b ecame imbalance,and the spleen produced antitumor immunosuppression,and weaken ed the host immune function.
【Fund】: 卫生部科研基金资助项目 (941 1 36)
【CateGory Index】: R735.7
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