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《Chinese Journal of Experimental Surgery》 2002-06
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Peroxisome proliferator activated receptor γ (PPARγ) is aberrantly expressed in pancreatic carcinoma

WANG Xingpeng,XU Xuanfu,WANG Bingxian,et al.Department of Gastroenterology,Shanghai First People's Hospital,Shanghai 200080,China  
Objective To determine if peroxisome proliferator activated receptor (PPAR) was expressed in pancreatic carcinoma and to evaluate its possible significance.Methods Expressions of PPARα,δ,γ in normal pancreatic tissue,24 cases of pancreatic carcinoma tissue,as well as in pancreatic cell lines,PC 3 and PANC 1,were analyzed by using either immunohistochemical procedure or reverse transcription polymerase chain reaction (RT PCR).Results RT PCR showed that mRNA of PPAR subtype,PPARγ,was over expressed not only in pancreatic carcinoma tissue but also in pancreatic cell lines,while no expression was detected in normal pancreatic tissue.The PPAR subtypes,PPARα and PPARδ,were not detected both in normal pancreatic tissue and in pancreatic carcinoma tissue and pancreatic cell lines.Immunohistochemical study showed that PPARγ was markedly increased in pancreatic carcinoma tissue with overall positive rate of 79.17%.Conclusion PPARγ gene and protein expression in pancreatic carcinoma tissue and cell lines is up regulated.This indicates that nuclear receptor PPARγ is a novel target for chemopreventive strategies for the pancreatic carcinoma.
【Fund】: 上海市科技发展基金重点资助项目 ( 994 1190 16 )
【CateGory Index】: R735.9
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