Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Experimental Surgery》 2003-12
Add to Favorite Get Latest Update

Expression of mRNA for DNA methyltransferase 1, 3a and 3b in bladder carcinoma

ZENG Yu;KONG Chui-ze;ZHU Yu-yan, et al. Department of Urology, The First Clinical College, China Medical University, Shenyang 110001, China  
Objective To evaluate the significance of aberrant DNA methyltransferase (DNMTs) expression in human bladder carcinoma. Methods The levels of mRNAs encoding DNA methyltransfer- ases were measured by reverse transcription followed by semi-quantitative detection of PCR products. Re- sults The positive expression rate and the average level of mRNA for DNMT1 and DNMT3b in bladder cancers were all significantly higher than in normal bladder mucosae (P 0. 05), whereas the expression of DNMT3a in the two groups showed no significant difference (P 0. 05). There was no significant correlation between the expression of DNMTs and the clinicopathological parameters of tumors (histologi- cal classification, clinical stage, morphological type of tumors, primary case or recurrence case, P 0. 05). Over-expression of DNMT1 mRNA was significantly associated with that of DNMT3b (P 0. 01). Con- clusion Both over-expression of the maintenance DNA methyltransferase DNMT1 and over-expression of de novo DNA methyltransferase, DNMT3b, are involved in human bladder carcinogenesis. There could be a certain co-regulation mechanism between DNMT1 and DNMT3b.
【CateGory Index】: R737.14
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 5 Hits
1 ZHANG Shilong,ZENG Fuqing,ZHU Chaohui et al.Department of Urology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022;Construction of the eukaryotic expression vector carrying double shRNA sequence targeting the conserved domain of gene DNMT3b[J];Central China Medical Journal;2008-04
2 ZENG Fuqing,ZHANG Shilong,PENG Shibo et al.Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022;Construction of the eukaryotic expression vector carrying double shRNA sequence targeting gene DNMT1 and its influence on expression of DNMT1.[J];Central China Medical Journal;2008-05
3 ZHONG Zhaohua;JIANG Wenwen;LI Zhimei;Chemical school of Nanchang University;Food school of Nanchang University;;Detection of DNA methyltransferase Dam activity using the electrochemical techniques based on the recycling DNA chain amplification[J];Journal of Nanchang University(Natural Science);2014-06
4 Zhang Shilong,Zeng Fuqing,Peng Shibo et al Department of Urology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022;Influence of Silencing DNMT1 with shRNA on Proliferation and Apoptosis of Bladder Cancer Cell Line T24[J];Acta Medicinae Universitatis Scientiae et Technologiae Huazhong;2009-02
5 Wu Zhenqi1, 2, Zhang Xu1△, Liu Yi2 et al1Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 4300302Department of Urology, Dongfeng General Hospital, Yunyang Medical College, Shiyan 442008;The Expression and Significance of DNMT1 and DNMT3b Genes in Human Bladder Carcinoma Tissues and Cells[J];Acta Medicinae Universitatis Scientiae et Technologiae Huazhong;2009-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WANG Li-hong et al (Shandong Analysis and Test Centre,Shandong Academy of Sciences,Jinan,Shandong 250014);Developments in Understanding Mechanisms of Arsenic Metabolism and Detoxification in Organisms[J];Journal of Anhui Agricultural Sciences;2009-17
2 CHEN Dao-Rong1, WANG Pi-Long1, HUANG Ai-Long2, ZHANG Bing-Qiang2 1. Department of Gastroenterology,The First Affiliated Hospital,Chongqing University of MedicalSciences,Chongqing, 400016,P. R. China2. Institute for Viral Hepatitis,Chongqing University of MedicalSciences,Chongqing, 400010,P. R. China;Effects of dnmt1 Gene Silencing on Cell Cycle, Proliferation,and Apoptosis of Gastric Cancer Cell Line AGS[J];Chinese Journal of Cancer;2006-03
3 RUI Li,XUE Wan-Jiang,LI Peng,WANG Zhi-Wei,WANG Peng,LI Hou-Xiang Department of General Surgery,The Affiliated Hospital of Nantong University,Nantong,Jiangsu,226001,P.R.China;Inhibitory Effect of Wild-type RASSF1A Gene Expression on Proliferation of Hepatocellular Carcinoma QGY-7703 Cells[J];Chinese Journal of Cancer;2008-09
4 Qu Hongzhang et al.;STUDIES ON PATHO-MORPHOLOGY OFV EXPERIMENTAL SELENIUM-DEFICIENCY IN DUCKLINGS[J];;1986-04
5 LI Ling~1 WU Jun~(2*) JIANG Ling~1 OU Bing~2 ZHANG Yun~2 LI Cheng-xiu~1 CHENG Ming-liang~2 YANG Qin~3 1.Department of Pharmacology,Guiyang Medical Colleges,Guiyang 550004,China 2.Department of Infectious Diseases,Affiliated Hospital Guiyang Medical College,Guiyang 550004 3.Department of Pathophysiology,Guiyang Medical College,Guiyang 550004;Hepatic damages in mice exposed to drinking water containing arsenic of different valence states[J];Academic Journal of Second Military Medical University;2008-05
6 HOU Shao fan, WANG Wu yi, LI Hai rong, YANG Lin sheng(Institute of Geographical Sciences and Natural Resources Research,CAS, Beijing 100101 China);Study on the Geographically Epidemic Character of Arsenism and Its Countermeasures[J];Progress In Geography;2002-04
7 ZHANG Hong, XIAO Wen hua, LIANG Hou jie, FANG Dian chun,YANG Shi ming, LUO Yuan hui (Department of Oncology and Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Apoptosis of hepatocarcinoma SMMC-7721 cells induced by the transfected human antisense DNA MTase gene[J];Acta Academiae Medicine Militaris Tertiae;2002-11
8 WANG Bing 1, WANG Mei 2, LIANG Qin Long 3,MO Li-Ping 1,ZHANG Jia n 1, HAN Shui Ping 1, SU Min 1 1Department of Pathology, Medical College, 2Department of De rmatology, Second Hospital, Xian Jiaotong University, Xian 710061, China, 3Department of Head & Neck, Tumor Hospital of Shaanxi Province;Effects of selenium on the morphology and NSE IGFR expression in rats' cerebral cortex neurons in vitro[J];Journal of The Fourth Military Medical University;2003-02
9 Zhang Zhanyuan et al(The Institute of Endemic Diseases Control of Liaoning Province,Shen yang);THE EFFECT OF THYRO-OXYINDOLE,I,SE AND F ON REPRODUCTION OF HUMAN EMBRYOBRAIN CELL CULTURED IN VITRO AND PENETRATION OF ~3H-TdR[J];Chinese Journal of Control of Endemic Disease;1990-06
10 ZUO Shi1,ZOU Shengquan2,SUN Chengyi1 (1.Department of Hepatobiliary Surgery,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou,China;2.Department of General Surgery,the Affiliated Tongji Hospital of Tongji Medical College,Huazhong Science & Technology University,Wuhan 430030,Hubei,China);The Expression and Significance of DNA Methyltransferase 1 Gene in Extrahepatic Cholangiocarcinoma Tissues and Cells[J];Journal of Guiyang Medical College;2011-03
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 Yuan Xiaoyi,Bao Shixin,Yang Weimin et al Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;The Construction and Identification of siRNA Adenovirus Expression Vector Targeting LRIG3 Gene[J];Acta Medicinae Universitatis Scientiae et Technologiae Huazhong;2010-01
2 Zhang Yuan;Yang Xunxun;Wu Fengrui;Liu Yong;Ding Biao;Wang Caihong;Huang Jichang;Li Wenyong;College of Life Science,Anhui Agricultural University;Key Laboratory of Embryo Development and Reproductive Regulation;College of Life Science,Fuyang Normal University;;Construction and Analysis of Luciferase Reporter Vectors of Mouse Dnmt1 Gene Promoter[J];Biotechnology Bulletin;2013-10
3 Wei-Dong Xiao, Yong Li, Xue-Ming Li, Jun Cai, Lin-Shan Zeng, Wei Hu, Department of General Surgery, the First Affi liated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China;RNA interference-mediated silencing of the DNMT1 gene inhibits cell proliferation in human pancreatic carcinoma cell line BxPC-3[J];World Chinese Journal of Digestology;2011-33
4 LIU Qi-ming(Suining People′s Hospital,Xuzhou,Jiangsu,221200);The expression and clinical significance of DNA methylation transferase enzyme 1 in non-small cell lung cancer[J];Journal of Clinical Medicine in Practice;2011-23
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved