Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Experimental Surgery》 2004-09
Add to Favorite Get Latest Update

Expression of Peroxisome Proliferator-actived Receptor Y in Renal Cell Carcinoma

YANG Feng-guang, SHI Chang-jin, ZHANG Zhi-wen, et al. Department of Urology, Frist Hospital, Peking University, Institute of Urology, Peking University, Beijing 100034, China  
Objective To investigate the expression of peroxisome proliferator-actived receptor γ (PPAR-7) in renal cell carcinoma and to evaluate its possible significance. Methods The expression of PPAR-y mRNA and protein was detected in NK (normal kidney) tissues, RCC (renal cell carcinoma) tissues, two RCC-derived cell lines (786-O and A498) and two NK-derived cell lines HK-2 and HMCC by using RT-PCR and Western blot analysis. Immunohistochemistry was performed on specimens from 120 patients with RCC and from 20 NK tissues to examine the expression and localization of PPAR-γ. Results PPAR-γmRNA was expressed in all NK, RCC tissues, two RCC cell lines and two NK cell lines. The level of PPAR-γ protein was about 7.0-10.7 folds in RCC compared to NK by Western blot analysis. Immuno-histochemical study showed that PPAR-7was markedly increased in renal cell carcinoma tissues (t = 7.888, P 0.01)with overall positive rate of 98.3 % . PPAR-γ was strongly expressed in the perinuclear and cytoplasmic regions in RCC tissues. PPAR-γ expression was correlated with the stage and grade of RCC. Conclusion The expression of PPAR γ is stronger in RCC than in NK. PPAR-γ may play a role in the pathogenesis and progression of RCC. Actived PPAR-γ may he a novel approach to the treatment of this refractory neoplasm.
【CateGory Index】: R737.11
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 5 Hits
1 WANG Ming-hua1, ZHONG Xue-yun2, LIN Chen-li2, XIE You-ke2, JIA Jin-ping2, LI Su-mei2, MI Can11Department of Pathology, Chongqing Medical Oniversity, Chongqing 410016, China; 2Department of Pathology, Meaical college of Ji'man University, Gnangzhou 510632, China;Expression of peroxisome proliferator-activated receptor γ in glioma[J];Journal of Southern Medical University;2008-03
2 Yang Fengguang,Ye Liefu,Lin Le,Li Tao,He Yanyu,Zhang Zhiwen,Guo Yinglu.Department of Urology,Fujian Provincial Hospital,Fuzhou 350001,China;Iufluence of peroxisome proliferator-activated receptor γ(PPARγ) ligands on angiogenesis in renal cell carcinoma[J];Fujian Medical Journal;2009-06
3 Niu Zhihong, Lv JiaJu, Zhang Hui, Ding Sentai, Gao DeXuan Department of Urology, Provincial Hospital affiliated to Shandong University, Jinan 250021, China;Expression of NOV and WISP-1 genes in prostate cancer tissues[J];Chinese Journal of Andrology;2010-04
4 SHU Zhen-bo,CAO Hai-pin,GAI Bao-dong,et al.(Department of Gastroenterology,China-Japan Union Hospital of Jilin University,Changchun 130033,China);Different expression and significance of peroxisome proliferator-activated receptor γ in colorectal cancer[J];Chinese Journal of Laboratory Diagnosis;2008-03
5 HE Kun,HU Ze-ming,ZHOU Zai-ping,CHEN Hong,DENG Hui-zhou The First Department of General Surgery,Zhongshan City People's Hospital (Zhongshan Affiliated Hospital of Sun Yat-Sen University), Zhongshan 528400,China;Different Expression and Significance of PPARγ in Hepatocellular Carcinoma[J];Cancer Research on Prevention and Treatment;2009-12
【Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Xingpeng,XU Xuanfu,WANG Bingxian,et al.Department of Gastroenterology,Shanghai First People's Hospital,Shanghai 200080,China;Peroxisome proliferator activated receptor γ (PPARγ) is aberrantly expressed in pancreatic carcinoma[J];Chinese Journal of Experimental Surgery;2002-06
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 SHEN Dan,DENG Changsheng.Department 1 of Internal Medicine & Geriatrics,Zhongnan Hospital,Wuhan University Wuhan 430071,China;Expression of peroxisome proliferator-activated receptor γ in human colon cancer and growth inhibition by its agonists[J];Journal of Clinical Internal Medicine;2008-01
2 Axiangu· Hasimu,Lalai· Suzuke,LI Qiao-zhi(Department of Pathology,Xinjiang Medical University,Urumqi 830054,China);Expression and significance of PPARγin cervical intraepithelial neoplasia and in cervical carcinoma[J];Journal of Xinjiang Medical University;2007-06
3 XU Xiao, MA Bin-lin, GENG Zhong-li, et alXinjiang Medical University, Urumqi 830011, China;A molecule pathology study in human breast cancer[J];Journal of Xinjiang Medical University;2008-02
4 Alibiyati ·Aini,XU Xiao,MA Bin-lin,GENG Zhong-li,WANG Jin(Department of Breast and Neck Surgery,Tumor Hospital,Xinjiang Medical University,Urumqi Xinjiang 830011,China);Expression of PTEN and PPAR_γ in human breast cancer[J];China Oncology;2008-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 SITU Rui, WANG Hui-Hua, WANG Jin-Huan(Department of Pathology, Medical College, The Ji-Nan University) HE Li-Peng, ZHU Xian-Lung(Department of Surgical Nurology) OU Wai-Fong(Department of Chinese Medicine);ESTABLISHMENT OF HUMAN BRAIN MALIGNANT GLIOMA CELL LINE(SWO-38) AND OBSERVATION OF ITS BIOLOGIC PROPERTIES[J];Chinese Journal of Cancer;1987-04
2 XIONG Zuying *, HUANG Haichang, LI Jingzi, WANG Haiyan △ (Renal Division of Peking University First Hospital;Institute of Nephrology, Peking University,Beijing 100034, China);PPAR-γ expression in the kidney of actively proliferating glomerulonephritis[J];Journal of Peking University(Health Sciences);2003-05
3 YANG Feng guang 1, ZHANG Zhi wen 2△ , XIN Dian qi 1, SHI Chang jin 1, WU Xue qing 1, LIU Wu jiang 1,GUO Ying lu 1, WU Jie ping 1 (1.Department of Urology,Peking University First Hospital; Peking University Institute of Urology; 2. Department of Physiology,Peking University School of Basic Medical Sciences,Beijing 100083,China);Peroxisome proliferator-actived receptor-γ ligand troglitazone induces apoptosis in renal cell carcinoma[J];Journal of Peking University(Health Sciences);2004-02
4 LI Ming, MU Yi Ming *, MA Fang Ling, WANG Bao An, DOU Jing Tao, LU Ju Ming, LI Jiang Yuan, PAN Chang Yu (Department of Endocrinology, General Hospital of PLA, Beijing 100853,China) [;Nuclear receptor agonist regulating aromatase activity in human ovarian granulosa and breast cancer MCF-7 cells[J];Academic Journal of Second Military Medical University;2003-06
5 ZHAO Wen 1, SHI Jing quan 1, BIAN Xiu wu 1, WAN Ying 2, LU Jia you 1 ( 1Institute of Pathology, Southwest Hospital, 2Institute of Immunology, College of Medicine, Third Military Medical University, Chongqing 400038, China);Effects of antisense GFAP retrovirus on cell proliferation and differentiation of human glioma cell line[J];Acta Academiae Medicinae Militaris Tertiae;2004-18
6 GUO Chun-bao1, WANG Shan1, JIN Xian-qing1, ZHANG Dian-liang2 (1The First Department of Surgery, Children’s Hospital of Chongqing Medical University, Chongqing 400014, 2 Department of General Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, China);Role of heat shock protein 70 in human glioma drug resistance in vitro[J];Acta Academiae Medicinae Militaris Tertiae;2007-07
7 HE Xiaoyan, ZHANG Min, CHEN Zhichao, YOU Yong, TIAN Lei, ZOU Ping. Department of Hematology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R.China;Expression of PPAR-γ and its apoptotic significance in lung cancer[J];Chinese Journal of Lung Cancer;2006-01
8 LI Yunfeng,QIAN Haili,LIN Chen State Key Laboratory of Molecular Oncology,Cancer Institute,Chinese Academy of Medical Sciences,Beijing,100021,China;Regulation and Function of Gadd45a[J];Journal of Medical Molecular Biology;2007-05
9 Ma Jie, Lai Yongrong, Ning Zijue (Department of Hematology, the First Clinical Medical College of Guangxi Medical University , Nanning 530021 China);EXPRESSION OF BCL-GENE IN ADULT ACUTE LEUKEMIA AND ITS CLINICAL IMPLICATION[J];Journal of Guangxi Medical University;2002-02
10 DAI Wenxiang1 CAO Jianguo2 ZHUANG Yingzhi1 ZHOU Tingfang1 (Department of Tumorlogy Medicine, the First Affiliated Hospital of Nanhua University, Hengyang, Hunan 421001, China;2Instisute of Oncology, Nanhua University);Effects of rosiglitazone on proliferation and differentiation of HL-60 cell[J];Journal of Clinical Hematology;2006-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved