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《Chinese Journal of Experimental Surgery》 2007-07
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The establishment of the chronic and gradual biliary obstruction model in mini-pigs

CHEN Wen-bin HUANG Zhi-qiang CHEN Yong-liang Hepatobiliary Surgery Institute,General Hospital of PLA,Beijing 100853,China  
Objective To establish a chronic and gradual biliary obstruction model in mini-pigs and to discuss its value in simulating pathological mechanism of biliary obstructive patients.Methods Under operation,the model was made by bundling up the common bile duct paralleled 16G pinhead with 10 # suture soaked in 5% iodine,after which the pinhead was withdrawn.A series of changes of common bile duct in pathology such as partial stenosis in early stage and aseptic inflammation,repairs,hyperplasy and stenosis in later stage were caused.Results In all of animal models,obstructive jaundice occurred 5 and 7 days after operation,then gradually aggravated,and there was no animal death within periods of 28 days. The level of TBIL was increased from (1.22±0.41)μmol/L to (125.90±35.77)μmol/L at post-oper- ative day 28 day (P0.01).The chronic fibrous scarrings of common bile duets with obstructed lumen were revealed pathologically.Conclusion The large animal model shows easy reproducibility and better survivability.With features of gradually chronic obstructive jaundice,the investigation can provide reliable evidence for clinical study on HCCA or biliary duct stegnosis.
【CateGory Index】: R657.4;R-332
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【References】
Chinese Journal Full-text Database 6 Hits
1 Hui Fang;Qiang-Pu Chen;Xing-Yuan Zhang;Fan Zhang;Chang-Xi Zhang;Yan-Min Lu;Liang Zhao;Shuai Yuan;Department of Hepatobiliary Surgery &Clinical Nutrition Support Center & Clinical Nutrition and Metabolism Key Laboratory,Affiliated Hospital of Binzhou Medical University;;Establishment and evaluation of a rat model of reversible obstructive jaundice[J];世界华人消化杂志;2015-25
2 CHEN Yong-liang,CHEN Wen-bin,WAN Yun-yan,LI Wen-gang,HUANG Zhi-qiang,WU Xiao-tong, YANG Jie;YANG Li Institute of Hepatobiliary Surgery Department of Radiology General Hospital of People's Liberation Army,Beijing 100853,China Department of General Surgery,the 264th Hospital of People's Liberation Army,Taiyuan,Shanxi 030001,China Department of Hepatobiliary Pancreas and Vessel Surgery, Chenggong Hospital of Xiamen University,Xiamen,Fujian 361000,China;Effects of partial portal vein arterialization on liver regeneration after hepatectomy in minipigs with obstructive jaundice[J];Chinese Medical Journal;2012-13
3 ZHONG Hong-liang, WANG Zhen-min,ZHAO Fu,YANG Zhi-jun,LIU Pi-nan.Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China;The minipig model of CO_2 laser fascia to dura soldering for dural reconstruction[J];中华实验外科杂志;2011-09
4 CHEN Wen-bin,TAN Wen-jun,WU Xiao-tong,CHEN Qi-guo,GONG Xu-dong,LIU Yan.Department of General Surgery,the 264th Hospital of PLA,Taiyuang 030001,China;Effect of portal vein arterialization on hepatic functional reserve following hepato-biliary resection in miniature pigs with obstructive jaundice[J];中华实验外科杂志;2011-08
5 Shui-Ping Yu, Jian Li, Bing-Zong Hou, Yong-Hui Su,Pei-Ping Li, Bai-Meng Zhang, Department of GeneralSurgery (Division III), the Fifth Affi liated Hospital of SunYat-sen University, Zhuhai 519000, Guangdong Province,China;Evaluation of rat models of acute and chronic obstructive jaundice[J];世界华人消化杂志;2011-12
6 CHEN Wen-bin~*,HUANG Zhi-qiang,CHEN Yong-liang,et al.*Department of General Surgery,the 264th Hospital of PLA,Taiyuan 030001,China;Effect of portal vein arterialization on liver regeneration after hepato-biliary resection in miniature pigs with obstructive Jaundice[J];中华实验外科杂志;2008-07
【Citations】
Chinese Journal Full-text Database 2 Hits
1 CHEN Jin-jun~* LI Yong ZHANG Qing-fu Department of Hepatobiliary Surgery,The First Hospital of Hebei Medical University,Shijiazhuang 050031,China;Changes and significance of small intestine mesenteric microcirculation in rats with obstructive jaundice[J];中华实验外科杂志;2006-11
2 Xia Ronglong, Liu Qingguang, Yao Yingmin, et al Department of Hepatiobiliary Surgery,First Hospital of Xi'an Jiaotong University,Xi'an 710061,China;The establishment and evaluation of the chronic biliary obstruction model on SD rats[J];西安医科大学学报;2001-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Hui Fang;Qiang-Pu Chen;Xing-Yuan Zhang;Fan Zhang;Chang-Xi Zhang;Yan-Min Lu;Liang Zhao;Shuai Yuan;Department of Hepatobiliary Surgery &Clinical Nutrition Support Center & Clinical Nutrition and Metabolism Key Laboratory,Affiliated Hospital of Binzhou Medical University;;Establishment and evaluation of a rat model of reversible obstructive jaundice[J];世界华人消化杂志;2015-25
2 ZHANG Hong-zhan;ZHANG Ming-ming;HU Bing;Graduate College,Soochow University;;Establishment of benign biliary stricture model in rabbits and study of its mechanism[J];中华临床医师杂志(电子版);2013-13
3 Lü Yun-fu~*,WANG Bao-chun,GONG Xiao-guang,HAN Xiao-yu,ZHANG Shi-jie,LIU Ning,WENG Shao-wen.*Department of Surgery,People's Hospital of Hainan Province,Haikou 570311,China;Correlation among pressure,diameter,and jaundice in acute obstruction of common bile duct[J];中华实验外科杂志;2011-11
4 ZOU Ling,PENG Yan;Injury and mechanism of intestinal barrier function caused by obstructive jaundice[J];实用医院临床杂志;2011-06
5 Shui-Ping Yu, Jian Li, Bing-Zong Hou, Yong-Hui Su,Pei-Ping Li, Bai-Meng Zhang, Department of GeneralSurgery (Division III), the Fifth Affi liated Hospital of SunYat-sen University, Zhuhai 519000, Guangdong Province,China;Evaluation of rat models of acute and chronic obstructive jaundice[J];世界华人消化杂志;2011-12
6 QIN Qi-yu,ZHANG Qing-fu,CHEN Jin-jun,WANG Che-jiang,PEI Yong-bin,WANG Wei. Department of the Liver and Gallbladder Surgery,The 1st Hospital of Hebei Medical University,Shijiazhuang 050031,Chi-na. LI Yong,FAN Li-qiao,ZHAO Qun. Department of Surgery,the 4th Hospital of Hebei Medical University,Shijiazhuang 050011,China;Alteration of Renal Cortex Microcirculation and the Effect of Salvia miltiorrhiz in Obstructive Jaundice Rats[J];中国微循环;2009-04
7 QIN Qi-yu,LI Yong,ZHANG Qing-fu,et al.Department of the Genneral Surgery,The First Hospital of Hebei Medical University,Shijiazhuang 050031,China;The significance of renal cortex microcirculation alteration in obstructive jaundice rats[J];疑难病杂志;2009-07
8 CHEN Xiao-bai1,ZHAO Shi-hua2,GAN Yao-kun3,WANG Xiao-ping4,HUANG Yue-he5(1.Senior Lecturer,Chemistry and Biology Dept.,Yulin Normal University,Yulin,Guangxi 537000)(2.Professor,Chemistry and Biology Dept.,Yulin Normal University,Yulin,Guangxi 537000)(3.Associate Professor,Chemistry and Biology Dept.,Yulin Normal University,Yulin,Guangxi 537000)(4.Assistant,Chemistry and Biology Dept.,Yulin Normal University,Yulin,Guangxi 537000)(5.Undergraduate,Chemistry and Biology Dept.,Yulin Normal University,Yulin,Guangxi 537000);Promoting Blood Circulation and Removing Blood Stasis by Abrus cantoniensis Hance[J];玉林师范学院学报;2009-03
9 TIAN Yanfeng1),LI Yong2),ZHAO Zengren1),ZHAO Qun2),FAN Liqiao2),SONG Zhenchuan2),ZHANG Xueming1),LI Fang1)1)Department of General Surgery,First Hospital of Hebei Medical University,Shijiazhuang 050031 2)The Third Department of General Surgery,the Fourth Medical University,Shijiazhuang 050011;Effects of ulinastatin on intestinal oxidative stress of rats with obstructive jaundice[J];郑州大学学报(医学版);2008-06
10 CHEN Wen-bin HUANG Zhi-qiang CHEN Yong-liang Hepatobiliary Surgery Institute,General Hospital of PLA,Beijing 100853,China;The establishment of the chronic and gradual biliary obstruction model in mini-pigs[J];中华实验外科杂志;2007-07
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 CUI Yubao;Department of Surgery, Tianjin First Hospital;;Effect of artenisiae scopariae and poriae powder on calpain-2 expression in liver tissue from rats with obstructive jaundice[J];中南大学学报(医学版);2015-05
2 Jun Chen;Jia-Tian Dong;Xiao-Jing Li;Ye Gu;Zhi-Jian Cheng;Yuan-Kun Cai;Department of General Surgery,Shanghai Fifth People’s Hospital,Fudan University;Department of Pathology,Shanghai Fifth People’s Hospital,Fudan University;Clinical Base of Emergency,Shanghai Fifth People’s Hospital,Fudan University;;Glucagon-like peptide-2 protects impaired intestinal mucosal barriers in obstructive jaundice rats[J];World Journal of Gastroenterology;2015-02
3 ZHAO Jingfei CHEN Qiangpu Department of Hepatobiliary Surgery,The Hospital Affiliated to Binzhou Medical College,Binzhou 256603;The study of epithelial cell proliferation and apoptosis in patients with obstructive jaundice[J];滨州医学院学报;2012-03
4 HAN Xin-ling,FENG Wen-yu,ZHU Yu-hong,et al.Department of Pediatric Surgery,Binzhou Medical College Hospital,Binzhou 256603,Shandong,China;Experimental Rat Model of Hepatic Fibrosis Induced by Partial Bile Duct Obstruction[J];中华全科医学;2011-05
5 Shui-Ping Yu, Jian Li, Bing-Zong Hou, Yong-Hui Su,Pei-Ping Li, Bai-Meng Zhang, Department of GeneralSurgery (Division III), the Fifth Affi liated Hospital of SunYat-sen University, Zhuhai 519000, Guangdong Province,China;Evaluation of rat models of acute and chronic obstructive jaundice[J];世界华人消化杂志;2011-12
6 WU Peng CHEN Qiangpu ZHANG Xingyuan Department of Hepatobiliary Surgery,Affiliated Hospital of Binzhou Medical University,Binzhou 256603;Effect of obstructive jaundice on intestinal epithelial structure and endotoxin translation in rats[J];滨州医学院学报;2010-03
7 LIANG Li-jian,CHEN Dong, TANG Di,LI Shao-qiang,PENG Bao-gang,HUANG Li,HUANG Jie-fu.Department of Hepatobiliary Surgery,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China;Construction of a modified rat model for obstructive jaundice[J];消化肿瘤杂志(电子版);2009-02
8 Stelios F Assimakopoulos, Department of Internal Medicine, University Hospital of Patras, Patras 26504, Greece Constantine E Vagianos, First Surgical Department, "Saint Panteleimon" General Hospital of Nikaia, Piraeus 18454, Greece;Bile duct ligation in rats: A reliable model of hepatorenal syndrome?[J];World Journal of Gastroenterology;2009-01
9 Yong-Liang Chen,Zhi-Qiang Huang,Xiao-Qiang Huang,Ming-Yi Chen,Wei-Dong Duan,Department of Hepatobiliary Surgery,General Hospital of Chinese PLA,Beijing 100853,China;Re-establishment of hepatic blood flow by portal vein arterialization and its influence on liver hemodynamics in rats with obstructive jaundice[J];世界华人消化杂志;2008-36
10 CHEN Wen-bin~*,HUANG Zhi-qiang,CHEN Yong-liang,et al.*Department of General Surgery,the 264th Hospital of PLA,Taiyuan 030001,China;Effect of portal vein arterialization on liver regeneration after hepato-biliary resection in miniature pigs with obstructive Jaundice[J];中华实验外科杂志;2008-07
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Chen Fangfang;Lu Zheng;Fu Xiaojun;Jiang Lei;Zhang Dakun;Xu Jianzhong;Department of General Surgery,the First Affiliated Hospital of Bengbu Medical College;;Establishment of a new rat model of reversible obstructive jaundice[J];中华实验外科杂志;2018-09
2 Li Xiaoyan;Xie Yaying;Yu Jianshe;Shi Haixia;Sun Junzhi;Department of Anesthesiology,First Affiliated Hospital of Inner Mongolia Medical University;;Effect of dexmedetomidine on damage to intestinal mucous membrane of rats with obstructive jaundice[J];中华麻醉学杂志;2017-11
3 Li Jun;Ren Jianjun;Zhang Junjing;Qiao Jianliang;Meng Xingkai;Department of General Surgery,the Affiliated Hospital of Inner Mongolia Medical University;;Updates of heterotopic auxiliary liver transplantation with portal vein arterialization[J];中华消化外科杂志;2015-09
4 Hui Fang;Qiang-Pu Chen;Xing-Yuan Zhang;Fan Zhang;Chang-Xi Zhang;Yan-Min Lu;Liang Zhao;Shuai Yuan;Department of Hepatobiliary Surgery &Clinical Nutrition Support Center & Clinical Nutrition and Metabolism Key Laboratory,Affiliated Hospital of Binzhou Medical University;;Establishment and evaluation of a rat model of reversible obstructive jaundice[J];世界华人消化杂志;2015-25
5 Wang Li;Chen Zhang;Li Kun;Leshan People's Hospital;Chengdu Army General Hospital;;The Study of the Ultrastructural changes of the Bile Duct Injury in the Obstructive Jaundice Experimental[J];四川医学;2015-07
6 Zhu Genglong;Cai Chaonong;Jia Yingbin;Hong Xiaopeng;Zhang Baimeng;Department of General Surgery,the Fifth Hospital Affiliated to Sun Yat-Sen University;;Fasudil protects from hepatic ischemia reperfusion injury in rats model of obstructive jaundice[J];中华肝胆外科杂志;2015-01
7 WANG Zhen-min1,ZHONG Hong-liang2,YANG Zhi-jun1,ZHAO Fu3,WANG Bo1,QU Pei-ran1,LIU Pi-nan1(1.Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,P.R.China;2.Department of Interventional Neurosurgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,P.R.China;3.Beijing Neurosurgical Institute,Beijing 100050,P.R.China);Application of lumbar puncture in minipig[J];中国现代医学杂志;2013-20
8 Wang Zhenmin1,Zhong Hongliang2,Yang Zhijun1,Zhao Fu3,Wang Bo1,Qu Peiran1,Wang Xingchao1,Liu Pi'nan1,3 1.Department of Neurosurgery,3.Beijing Neurosurgical Institute,Beijing Tiantan Hospital,Capital Medical University,Beijing 10050,China;2.Department of Interventional Neurosurgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China;Carbon dioxide laser soldering for dura reconstruction in minipig models[J];中国微侵袭神经外科杂志;2013-03
9 Shui-Ping Yu, Xue-Ling Zhou Shui-Ping Yu, Xue-Ling Zhou, Department of General Surgery, the Affiliated Hospital of Guilin Medical College, Guilin 541000, Guangxi Zhuang Autonomous Region, China;Treatment with rosuvastatin calcium improves liver fibrosis in a rat model of chronic obstructive jaundice[J];世界华人消化杂志;2012-35
10 Qiu Li, Yan Peng, Ling Zou, Wen-Guang Fu, Department of Hepatobiliary Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China;Effect of different biliary drainage methods on intestinal barrier function in rats with obstructive jaundice[J];世界华人消化杂志;2012-33
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