Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Nephrology》 2002-04
Add to Favorite Get Latest Update

Rhein retards the progression of type 2 diabetic nephropathy in rats

GUO Xiaohua, LIU Zhihong,PENG Ai, et al. Research Institute of Nephrology, Jinling Hospital, Nanjing Univisity School of Medicine, Nanjing 210002,China  
Objective To assess the effect of rhein on diabetic nephropathy in rats with type 2 diabetes mellitus. Methods Diabetes was induced by high-lipids and high-sucrose diets (20% sucrose, 10% lard, 2.5% cholesterol, 1% cholic acid and 66.5 % regular chow, w/w) for 1 month and then intraperitoneal injection with 25 mg/kg streptozoticin(STZ) in female inbred Wistar rats. Rhein was continuously given 100 mg·kg-1·day-1 for 6 months 1 week after STZ injection in rhein-prevented group, and 1 month after STZ injection in rhein-treated group. Blood and urinary biochemistry and renal morphology were evaluated at divers times. Results Rhein ameliorated hypertriglyceridemia and hypercholesterolemia, but had few effect on the level of plasma glucose in both rhein-prevented group and rhein-treated group. Excretion of urinary protein reduced markedly and stable-state plasma glucose (SSPG) level decreased in both groups as compared with diabetic group. Examination of kidney sections from both rhein-prevented group and rhein-treated group showed that the structural lesions of glomeruli including mesangial expansion, diffuse glomerulosclersis and thickening of glomerular basement membrane, as well as artery injury such as arteriolar hyalinosis, atherosclerosis were markedly improved as compared with diabetic group. Morphometry of glomeruli from both rhein-prevented group and rhein-treated group showed that glomerular grow and mesangial hypertrophy occurred in diabetic group were ameliorated. The accumulation of fibronectin examined by immunostaining in glomeruli was reduced in both groups. Conclusion Therapeutic intervention with rhein can halt the progression of diabetic nephropathy and prevent the development of glomerulosclerosis and vascular injuries in this animal model of type 2 diabetes mellitus.
【Fund】: 军队“十五”重点课题资助项目(01Z013)
【CateGory Index】: R692.9
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Bo;YUAN Yuan;HUANG Lu-qi;WANG Bao-min;NAN Tie-gui;College of Pharmacy,Shandong University of Traditional Chinese Medicine;State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences;College of Agronomy and Biotechnology,China Agricultural University;;Preparation and identification of artificial antigen for rhein[J];中国中药杂志;2015-08
2 LIU Hua;LI Shi-xiang;ZHONG Ye-jun;WU Dan;School of Life Science, Jiangxi Science & Technology Normal University;The National Key Laboratory of Food Science, Nanchang University;The Food and Drug Administration of Jiangxi Province;;Inhibitory Mechanism of Rhein on α-Amylase and Its Molecular Simulation[J];现代食品科技;2015-02
3 JU Jian-wei1,HE Yu-zhen2,ZHANG Li-mei2,YIN Yan-zhi1,MU Shou-han1,LV Cong-kui1(1Hospital of Yantai Economic and Technical Development Zone,Yantai 264006,China;2Binzhou Medical College,Yantai 264003,China);Effects of serum containing Zaohuang Mixture on the expression of monocyte chemotactic protein-1 in human mesangial cells cultured with high glucose[J];中华中医药杂志;2013-02
4 YUAN Jin-bin1,WANG Fa-ying2,LI Ming1,CHEN Hai-fang1,YANG Wu-liang1, LIU Ying-ying1,ZHANG Yu1(1.Key Laboratory of Modern Preparation of Traditional Chinese Medicine(TCM),Ministry of Education,Jiangxi University of TCM,Nanchang 330004,China;2.Lishui Institute for Food and Drug Control,Lishui 323000,China);Determination of Rhein in Plasma by SPE-HPLC and Its Pharmacokinetic Study in Rats[J];中国实验方剂学杂志;2011-18
5 Peng Wei1,Liu Zheng-rong2 1Department of Nephrology,Wu Jing Zong Dui Hospital of Guangdong Province,Guangzhou 510507,Guangdong Province,China;2Department of Nephrology,Nanfang Hospital Affiliated to Southern Medical University,Guangzhou 510515,Guangdong Province,China;Location and distribution of bone marrow mesenchymal stem cells in the kidney of IgA nephropathy rats[J];中国组织工程研究与临床康复;2011-23
6 Chen Hanqing,Xie Xinling,Jin Xiaoxiao,et al First Clinical Medical Institute of Zhejiang Chinese Medical University,Hangzhou(310053);Study of Therapeutical Effects of Rhubarb Apozem in Mice with Adriamycin Nephropathy[J];浙江中医药大学学报;2011-02
7 Zhang Li-mei1,He Yu-zhen1,Yin Yan-zhi2,Mu Shou-han2,Ju Jian-wei2,Lü Cong-kui2,Li Du-jun2 1College of Traditional and Western Medicine,Binzhou Medical University,Binzhou 264003,Shandong Province,China;2Department of Nephrology,Hospital of Yantai Economic and Technical Development Zone,Yantai 264006,Shandong Province,China;Effects of serum containing Zaohuang mixture on the expression of connective tissue growth factor in human mesangial cells cultured in vitro[J];中国组织工程研究与临床康复;2011-11
8 LIU Wei,WANG Jianqin,WANG Xiaodong,YANG Qinghua,WANG Dong(Second Hospital of Lanzhou University,Lanzhou 730030,China);Effects of Shenbao recipe on expressions of CTGF and MMP-9 in diabetic nephropathy rats[J];中国中药杂志;2010-14
9 ZHANG Jin-wen1,SUN Jian-guo1,WANG Guang-ji1,XIE Hai-tang1,2,GU Yi1,JIA Yuan-wei1,2,ZHENG Chao-nan1,LI Lei-shi3,LIU Zhi-hong3,ZHANG Hai-tao31Key Laboratory of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University,Nanjing 210038,Jiangsu,China; 2Institute of Clinical Pharmacology of Yijishan Hospital,Wuhu 241001,Anhui,China; 3Research Institute of Nephrology,Nanjing Hospital,Nanjing 210002,Jiangsu,China;Pharmacokinetic comparision in absorption of Rhein in SD rats and Beagle dogs[J];中国临床药理学与治疗学;2010-05
10 PAN Li-min,WANG Yue-hua,BIAN Dong,GUO Deng-zhou,WANG Yan-kai(Hebei of TCM,Shijiazhuang 050011,China);The Effect of Shenyanning on IgA Nephropathy Rats in Terms of the Expression of Vascular Endothelial Growth Factor[J];中国中医基础医学杂志;2010-02
【Citations】
Chinese Journal Full-text Database 7 Hits
1 GUO Xiaohua,LIU Zhihong,WANG Jianping,ZHU Maoyian,CHENG Huiping,LI Leishi Research Institute of Nephrology,Jingling Hospital,Nanjing University School of Medicine,Nanjing,210002;Rhein halts the progression of diabetic nephrology in NOD mice[J];肾脏病与透析肾移植杂志;2002-01
2 ZHU Jiaming, LIU Zhihong *, LI Yingjian, et al. *Research Institute of Nephropathy, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China;Inhibition of glucose transporter 1 overexpression in mesangial cells by rhein[J];中华内科杂志;2001-08
3 GUO Xiaohua,LIU Zhihong,DAI Chunsun,LI Heng,LIU Dong,LI Leishi Research Institute of Nephrology,Jinling Hospital,Nanjing University School of Medicine,Nanjing,210002;The effect of rhein on the hypertrophy of renal tubular epithelial cell and accumulation of extracellular matrix induced by transforming growth factor β[J];肾脏病与透析肾移植杂志;2001-02
4 LIU Zhi-Hong, LI Ying-Jian, CHEN Zhao-Hong, LIU Dong, LI Lei-Shi(Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China);Glucose transporter in human glomerular mesangial cells modulated by transforming growth factor-beta and rhein[J];Acta Pharmacologica Sinica;2001-02
5 WT5”BX]GUO Xiaohua,LU Zhihong,LI Hen,ZHU jiaming,LI Leishi Research Institute of Nephrology,Jinling Hospital,Nanjing University Clinical School of Medicine,Nanjing 210002;A NOVEL RAT MODEL OF TYPE 2 DIABETES MELLITUS[J];肾脏病与透析肾移植杂志;2000-04
6 ZHANG Jing,LIU Zhihong,LI Yingjian,et al.Research Institute of Nephrology,Jinling Hospital,Nanjing University, School of Medicine,Nanjing,210002;Effect of rhein on glucose transporter 1 expression and glucose uptake in mouse glomerular mesangial cells cultured in vitro[J];中华内分泌代谢杂志;1999-04
7 Yang Jun-wei, et al. Jingling Hospital.Nanjing 210002;EFFECT OF RHEUM OFFICINALE ON EXPERIMENTAL DIABETIC NEPHROPATHY[J];中华内分泌代谢杂志;1993-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LIU Zhantao;YANG Zhihong;JIANG Lingyan;GAO Hua;School of Pharmacy,Qingdao University;;THE EFFECT OF YOUFUQUAN WATER ON TYPE 2DIABETIC RATS[J];齐鲁医学杂志;2015-06
2 LI Hui-hui;HU Na-ping;LIU Mei-you;CHU Jian-jie;SUN-Jin;LI Fan;LU Cheng-tao;WEN Ai-dong;College of Pharmacy, Shanxi University of Chinese Medicine;Department of Pharmacy, Xijing Hospital, Fourth Military Medical University;;Kidney protection of rhein and Hydroxysafflower yellow A used alone or in combination on chronic kidney disease[J];药物评价研究;2015-06
3 PAN Weiyu;LU Yanmeng;LIANG Kangli;NIE Zhaoyuan;FAN Ping;The First Affiliated Hospital of Guangzhou Medical University;Instrumental Analysis & Research Center, Southern Medical University;The Third Affiliated Hospital of Guangzhou Medical University;;Effect of Sanqi Oral Liquid on Podocytes and Slit Diaphragm-associated Molecules Expression in Diabetes Mellitus Rats After Unilateral Nephrectomy[J];广州中医药大学学报;2015-05
4 ZENG Jing;ZHANG Xiang;YU Rong;TANG Yuan;LUO Wen-juan;CHEN Cong;WU Yong-jun;Graduate School,Hunan University of Chinese Medicine;Hunan University of Chinese Medicine;;Research on the Combined Detection of Urine UmAlb and Urinary Nephrin,Podocalyxin in Podocyte of MKR Mice with Diabetic Nephropathy[J];四川大学学报(医学版);2015-05
5 WANG Yaoguang;GONG Hua;JIN Aijing;GUO Renyong;Physical Education College,Liaoning Normal University;Faculty of Education and Arts,Federation University Australia;College of Life Science,Liaoning Normal University;;Exercise intensity induced the transduction of IRS-2 in skeletalmuscle of T2DM rats[J];辽宁师范大学学报(自然科学版);2015-03
6 CHEN Wei-dong;ZHANG Ji-qiang;ZHANG Yan;YIN Xiao-li;ZHANG Hai-feng;LIU Lei;CHANG Bao-chao;Department of Nephrology,No. 1Affiliated Hospital of Bengbu Medical College;;Effects of triptergium glycosides on the expression of MMP-9 and TIMP-1 in rats with early diabetic nephropathy[J];中国临床药理学杂志;2015-12
7 ZHANG Hui;MIAO Fu-rui;LUO Yu-ying;LIU Jun-ling;FAN Yu-shan;College of Acupuncture and Massage,Guangxi University of Traditional Chinese Medicine;The Ruikang Affiliated Hospital of Guangxi University of Traditional Chinese Medicine;Fangchenggang Municipal Hospital of Traditional Chinese Medicine;Institute of Acupuncture and Moxibustion ,China Academy of Chinese Medical Sciences;;Effect of Moxibustion with Ignited Zhuang-medicine Medicated-thread on Interstitial Cells of Cajal in Gastric Antrum in Diabetic Gastroparesis Rats[J];针刺研究;2015-02
8 WANG Sai;LIU Qun;HAN Jin-tan;KANG Lan-lan;YANG Yong;College of Life Science and Technology,Southwest University for Nationalities;;Therapeatic Test of Hyperglycemia in Mouse Model with Scindapsus aureus[J];动物医学进展;2015-04
9 LIU Hua;LI Shi-xiang;ZHONG Ye-jun;WU Dan;School of Life Science, Jiangxi Science & Technology Normal University;The National Key Laboratory of Food Science, Nanchang University;The Food and Drug Administration of Jiangxi Province;;Inhibitory Mechanism of Rhein on α-Amylase and Its Molecular Simulation[J];现代食品科技;2015-02
10 LI Hui-li;PANG Jun;Dept. of Nephrology,Jiande Municipal First People's Hospital;Nephropathy Center,The Affiliated Yangming Hospital of Medical College of Ningbo University;;Clinical Observation of Emodin Combined with Cyclophosphamide in the Treatment of Lupus Nephritis[J];中国药房;2015-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 CHEN Lei;LI Qiu-hong;WEI Qing-yi;NING Zheng-xiang;YUAN Er-dong;College of Light Industry and Food Science,South China University of Technology;Yichun University;;Study on the inhibition of kaempferol on α-amylase[J];食品工业科技;2013-22
2 WAN Ping1,SUN Jianguo1*,HAO Gang1,ZHANG Xiaoxuan1,XIAO Dawei2,LIU Zhihong3,WANG Guangji1** 1Key Lab of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University,Nanjing 210009;2Stage I Clinical Laboratory,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008;3Research Institute of Nephrology,Jinling Hospital,Nanjing University School of Medicine,Nanjing 210002,China;Determination of rhein in plasma,urine and feces by HPLC-fluorescence detection and its pharmacokinetics in healthy volunteers[J];中国药科大学学报;2013-01
3 HE Fu-yuan1,2,DENG Kai-wen3,ZENG Jiao-li1,2,DAI Ru-wen1,2,XIA Zan-shao2,LIU Weng-long1,2,SHI Ji-lian1,2(1.Department of Pharmaceutics,Hu'nan University of Chinese Medicine,Changsha 410208,China; 2.Property and Pharmacodaynamic Key laboratory of Chinese Materia Medica,State Administration of Chinese Medicine,Changsha 410208,China; 3.Modern Pharmaceutical Preparation Technology and Evaluation Laboratory for Chinese Materia Medica,Hunan University of Chinese Medicine,Changsha 410208,China; 4.The First Affinity Hospital,Hunan University of Chinese Medicine,Changsha 410007,China);Current state of studies on screening method for sensitinogens in injections for traditional Chinese medicine and synthetic immunity method[J];中国中药杂志;2012-19
4 ZHANG Shuguang,WANG Junping,SHENG Wei,ZHANG Yan,WANG Shuo(Key Laboratory of Food Nutrition and Safety,Ministry of Education,College of Food Engineering and Biotechnology,Tianjin University of Science & Technology,Tianjin 300457,China);Metolcarb Residue Analysis Using ELISA in Chinese Herbal Medicines[J];天津科技大学学报;2012-03
5 LI Gang1,2, ZHAO Jing2, HE Su-ping2, DENG Ai-xing2, LI Zhao-hu2, HE Zhong-pei2, ZHAO Huan-huan2, WANG Bao-min2(1.Agricultural Environment and Resources Research Center,Jilin Agricultural Science and Technology College,Changchun 132109,China;2.College of Agronomy and Biotechnology,China Agricultural University,Beijing 100094,China);Preparation of Glycyrrhizinic Acid Polyclonal Antibody and Development of ELISA for Glycyrrhizinic Acid Detection[J];时珍国医国药;2011-12
6 Zhang Li-mei1,He Yu-zhen1,Yin Yan-zhi2,Mu Shou-han2,Ju Jian-wei2,Lü Cong-kui2,Li Du-jun2 1College of Traditional and Western Medicine,Binzhou Medical University,Binzhou 264003,Shandong Province,China;2Department of Nephrology,Hospital of Yantai Economic and Technical Development Zone,Yantai 264006,Shandong Province,China;Effects of serum containing Zaohuang mixture on the expression of connective tissue growth factor in human mesangial cells cultured in vitro[J];中国组织工程研究与临床康复;2011-11
7 MU Shou-han1, YIN Yan-zhi1, JU Jian-wei1, LV Cong-kui1, ZHANG Li-mei 2 ( 1Yantai Economy Technology Development Zone Hospital, Yantai 264006, China; 2 Binzhou Medical University, Binzhou 256603, China );Effect of Zaohuang Misture on expressions of matrixmetalloproteinase-9 and tissue inhibitor of metalloproteinases-1 of human glomerular mesangial cells cultured under high glucose environment[J];中华中医药杂志;2010-11
8 NAN Tie-Gui1,HE Su-Ping1,TAN Gui-Yu1,LI Gang2,WANG Bao-Min1,HUANG Lu-Qi3 1(College of Agronomy and Biotechnology,China Agricultural University,Beijing 100193) 2(Agricultural Environment and Resources Research Center,Jilin Academy of Agricultural Sciences,Changchun 130033) 3(Institute of Chinese Medicine,Academy of Traditional Chinese Medicine,Beijing 100700);Development of Sensitive Monoclonal Antibody-based Enzyme-linked Immunosorbent Assay for Renal Toxicity Ingredient Aristolochic acid A in Chinese Herb Medicine[J];分析化学;2010-08
9 LIU Zi-qin, HUANG Hui-hua (College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China);Inhibition Effects of Extracts from Green Tea and Black Tea on α-Amylase[J];现代食品科技;2010-07
10 MA Hong-yan1,XU Ling1,XIAO Bing2,XU Yong1,YANG Jun1(1.Department of Endocrinology,the Affiliated Hospital,Luzhou Medical College,Luzhou,Sichuan 646000,P.R.China);Effect of MG132 on expression of Smurf 2 in glomerular mesangial cells induced by high glucose[J];中国现代医学杂志;2010-13
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Bo;ZHAN Zhi-lai;KANG Li-ping;YUAN Yuan;HUANG Lu-qi;DING Feng-wei;NAN Tie-gui;College of Pharmacy,Shan Dong University of Traditional Chinese Medicine;State Key Laboratory Breeding Base of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences;Shandong C.P.Freda Pharm Co.,Ltd.;;Preparation and immunogenicity identification of artificial antigen for luteoloside[J];中国中药杂志;2015-22
2 Wang Jian-qin;Zhao Peng-ming;Liang Yao-jun;Wang Jin-hua;Yang Yan;Department of Nephropathy, Second Hospital of Lanzhou University;;Protective effect of Baoshenfang on rats with renal interstitial fibrosis following unilateral ureteral ligation[J];兰州大学学报(医学版);2015-05
3 YANG Jia-pei;SUN Hao;WANG Dan-dan;MAO Yong;YU Feng;Department of Clinical Pharmacy,China Pharmaceutical University,Key Laboratory of Drug Quality Control and Pharmacovigilance,Ministry of Education;;MAPK Signal Transduction Pathway involves in Rhein-induced Apoptosis in HK-2 Cells[J];中国实验方剂学杂志;2015-15
4 LI Jian-hong;HUANG Min;XUE Yao-hua;DUAN Xing-wu;ZHENG He-ping;Dermatological Department, Dongzhimen Hospital, Beijing University of Chinese Medicine;Guangdong Provincial Dermatology Hospital;;Research on monomers activities of against chlamydia trachomatis in vitro extracted from rhubarb root and rhizome and amur cork-tree[J];中华中医药杂志;2015-08
5 ;Basic research on treating diabetic nephropathy with the Zaohuang mixture[J];中医临床研究;2015-16
6 LI-xia;WANG Jian-qin;CHEN Hong-ying;WANG Wen-ge;the Second Hospital of Lanzhou University,Department of VIP Internal Medicine;the Second Hospital of Lanzhou University,Department of Nephrology;the Second Hospital of Lanzhou University,Department of Hematology;;Clinical effects of Baoshenfang on patients with chronic kidney disease at 2-3 stage[J];国外医学(医学地理分册);2014-02
7 HUANG Jin-qiu;YAN Xue-mei;FENG Fang;Department of Pharmaceutical Analysis,China Pharmaceutical University;Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education);;Advances in the Pharmacokinetic Studies of the Anthraquinone Components in Rhubarb[J];广州化工;2014-10
8 Xing Liu;Wen-Ge Wang;Miao-Miao Ci;Hebei North University;Department of Pediatrics,Air Force General Hospital of People’s Liberation Army;;Comparison of rat models of cathartic colon established with rhein and rhubarb[J];世界华人消化杂志;2014-09
9 PENG Wei;HUANG Yan-qiang;LIU Zheng-rong;Division of Nephrology, Armed Police Hospital of Guangdong Province;;Effects of bone marrow mesenchymal stem cells on TGF-β_1 and MCP-1 in rats with IgA nephropathy[J];实用医学杂志;2013-20
10 ZHAO Yi-jie,ZHANG Dan-shen,ZHANG Li,ZHANG Xia-wei,JIN Can (Department of Pharmacy,Hebei North College, Zhangjiakou 075000,China);Preparation of rhubarb acid enteric-coated sustained-release pellets and its release study in vitro[J];中成药;2013-06
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 ZHU Jiaming, LIU Zhihong *, LI Yingjian, et al. *Research Institute of Nephropathy, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, China;Inhibition of glucose transporter 1 overexpression in mesangial cells by rhein[J];中华内科杂志;2001-08
2 GUO Xiaohua,LIU Zhihong,DAI Chunsun,LI Heng,LIU Dong,LI Leishi Research Institute of Nephrology,Jinling Hospital,Nanjing University School of Medicine,Nanjing,210002;The effect of rhein on the hypertrophy of renal tubular epithelial cell and accumulation of extracellular matrix induced by transforming growth factor β[J];肾脏病与透析肾移植杂志;2001-02
3 LI Ying Jian LIU Zhi Hong ZHANG Jing CHEN Zhao Hong LI Lei Shi (Jin Ling Hospital, Nanjing University School of Medicine, Nanjing 21002);IDENTIFICATION OF GLUCOSE TRANSPORTER 1 IN HUMAN MESANGIAL CELLS AND ITS FUNCTION ASSAY[J];细胞生物学杂志;1999-04
4 LIU Zhihong; LI Yingjian; ZHANC Jing; et al.(Institute of Nephrology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002);Modulatory effect of transforming growth factor-beta and Rhein on glucose transporter-1 in human glomerular mesangial cells[J];中华医学杂志;1999-10
5 Dai Chunsun, Liu Zhihong, Chen Huiping, Yang Junwei, Zhou Hong, Li Leishi Research Institute of Nephrology, Jinling Hospital,Nanjing University School of Medicine,Nanjing 210002;EFFECTS OF RHEIN IN INHIBITING THE PROGRESSION OF DIABETIC NEPHROPATHY IN STZ INDUCED DIABETIC RATS[J];肾脏病与透析肾移植杂志;1999-05
6 ZHANG Jing,LIU Zhihong,LI Yingjian,et al.Research Institute of Nephrology,Jinling Hospital,Nanjing University, School of Medicine,Nanjing,210002;Effect of rhein on glucose transporter 1 expression and glucose uptake in mouse glomerular mesangial cells cultured in vitro[J];中华内分泌代谢杂志;1999-04
7 LiuZhihong,ZhangTingting,WangJinquan,ChenZhaohong,ZhouHong,ChenHuiping,LiLeishiResea rchInstituteofNephrology,JinlingHospital,NanjingUniversitySchoolofMedicine,Nanjing,210002;DISTRIBUTIONOFGLUCOSETRANSPORTERSINRENALTISSUEANDITSRELATIONSHIPWITHDIAB ETICNEPHROPATHY[J];肾脏病与透析肾移植杂志;1999-03
8 Zhang Jing,Liu Zhihong,Chen Zhaohong,Liu Dong,Li Leishi Research Institute of Nephrology, Jinling Hospital (Nanjing, 210002);mRNA EXPRESSION AND FUNCTION OF GLUCOSE TRANSPORTER 1 IN MOUSE GLOMERULAR MESANGIAL CELLS[J];肾脏病与透析肾移植杂志;1998-03
9 Yang Jun-wei, et al. Jingling Hospital.Nanjing 210002;EFFECT OF RHEUM OFFICINALE ON EXPERIMENTAL DIABETIC NEPHROPATHY[J];中华内分泌代谢杂志;1993-04
10 Yang Junwei,et al (Department of Nephrology);Experimental study of rheum officinale(RO)on prevention of chronic renal failure(CRF)[J];金陵医院学报;1991-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved