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《Chinese Journal of Nephrology》 2002-04
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Effect of rhubarb extract on gene expression profile in diabetic nephropathy rats

CUI Chunli,MAJun,XIAO Zili,et al. Department of Nephrology,Tongji Hospital,Tongji University,Shanghai 200065, China  
Objective To study the effect of rhubarb extract on the gene expression profile in diabetic nephropathy rats, and analyze the mechanism of rhubarb on diabetic nephropathy in gene expression level. Methods Male rats without any treatments were used as the normal control group. Diabetic nephropathy was induced by streptozotocin in the rats as the diabetic nephropathy group. The diabetic nephropathy rats were treated with rhubarb extract as the rhubarb-treated group and with placebo as negative control group. The renal cortex was obtained from four groups. Cy5 or Cy3 fluorescent labeled DNA probes were prepared from mRNA and hybridized against the BioDoor Genechip, finally fluorescent signals were assayed and raw data was analyzed. Results There were about 8. 4 % genes altered in gene expression profile. The expression level of 12 genes were downregulated while 323 genes were upregulated significantly in the renal cortex of the diabetic animals. Compared with the negative control rats, 120 genes were downregulated and eight genes were upregulated significantly in the rhubarb-treated group, which occupied 3.3% of the total genes on the genechip. Furthermore, the expression changes of partial altered genes in the diabetic nephropathy group were reversed by rhubarb treatment. Conclusion Rhubarb is effective on the downregulation or upregulation of some differential expression genes, and can partially reverse streptozotocin-induced gene expression profile.
【CateGory Index】: R285.5
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