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《CHINESE JOURNAL OF NEPHROLOGY》 1996-03
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TheefectofrHuEPOonthecytokinesecretionofmononuclearcelsinmaintainedhemodialysispatients

JiangJianping,ZhangXun,HouFanfan.DepartmentofNephrology,NanfangHospital,Guangzhou510515  
bjectiveToevaluatetherelationshipbetweenanemiaandimmunefunctionaldefectofRBCinuremia.MethodsTwogroupsofmaintainedhemodialysis(HD)patientswithsevereanemiaweretreatedwithrHuEPOandtransfusionseparately.Thelevelsofinterleukin2(IL-2)secretedbyperipheralbloodmononuclearcels(PBM-NC)stimulatedwithPHA-Pandtumornecrosisfactor(TNF)secretedbyperipheralbloodmonocytes(PBMC)stimulatedwithLPSinthesupernatantandhemoglobin(Hb)beforeandaftertreatmentweremeasured.ResultsUremicanemiamaybeassociatedwithdecreasedcytokinesecretionandtherebymaycontributetotheuremicim-munodeficiencies.rHuEPOcanimproveuremicanemiaandenhancethecytokinesecretioninuremicpatients.Con┐clusionTheefectofrHuEPOonthecytokinesecretionseemstobemediatedbytheimprovingofanemia.
【CateGory Index】: R692.605
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