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Panax notoginseng saponins induced apoptosis of human renal interstitial fibroblasts and its mechanisms

Zhang Guoqiang, Ye Rengao, Kong Qingyu, et al. Department of Nephrology, The First Affiliated Hospital, Sun Yatsen University of Medical Sciences, Guangzhou 510080  
bjective To study the effects of Panax notoginseng saponins (PNS) on apoptosis of renal interstitial fibroblasts and its molecular mechanisms. Methods After preparation of cultured fibroblasts derived from kidneys with interstitial fibrosis, totol cell numbers, apoptosis, cMyc and Fas proteins were observed through flow cytometer. The programmed cell death was also confirmed by detection of broken ends of DNA. Results PNS obviously promoted the apoptosis of renal interstitial fibroblasts resulting in less cell number compared with control group. The apoptosis was associated with upregulation of cMyc protein. Fas protein was not affected by PNS. Conclusion PNS may be an effective drug for renal interstitial fibrosis.
【CateGory Index】: R285.5
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