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《Chinese Journal of Perinatal Medicine》 2004-06
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Research on the changes of expression of MMP 2 and TIMP 2 in the neonatal rats lung tissue caused by LPS

DU Yue, CAI Xu xu, WU Yu bin, et al. Department of Pediatrics, The Second Affiliated Hospital of China Medical University, Shenyang 110004,China  
Objective To investigate the function of metalloproteinase 2 (MMP 2) and tissue inhibitor of metalloproteinase 2 (TIMP 2) in neonatal acute lung injury(ALI) caused by LPS in rats. Methods Eighty eight newborn rats of 7 days were randomly divided into eight groups: control, 0.5 h, 1 h, 2 h, 4 h, 8 h, 16 h, 24 h after LPS was injected. The changes of lung pathology in newborn rats were observed and the changes of MMP 2 and TIMP 2 expression were measured by immunohistochemistry and RT PCR. Results Pulmonary hemorrhage was seen in newborn rats caused by LPS. The expression of MMP 2 mRNA and protein were 0.523±0.030 and 126.20±17.98; The expression of MMP 2 mRNA increased and the highest level was at 4 h(0.826±0.567, t=3.77, P 0.01). The expression of MMP 2 protein increased and the highest level was at 8 h(150.77±9.80, t=3.59, P 0.01). The expression of TIMP 2 did not changed. Conclusions The increased degradation of MMP 2 play an important role in the process of neonatal rats pulmonary hemorrhage caused by LPS.
【CateGory Index】: R722.1
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【References】
Chinese Journal Full-text Database 9 Hits
1 Zhou Haiyan,Wu Rong Department of Pediatrics,Chuzhou Clinical College of Anhui Medical University,Chuzhou 239000,China;Model of severe meconium aspiration in newly-born rabbits[J];Anhui Medical Journal;2010-09
2 Lin Na,Zhou Haiyan Wu Rong Department of Pediatrics,Chuzhou Clinical College,Anhui Medical University,Chuzhou 239000,China;Observation of the lung pathology of meconium aspirated newborn rabbits treated by dexamethasone[J];Anhui Medical Journal;2010-10
3 WANG Maojuan,YANG Xiaoqiong, DENG Shukai,WANG Rongli Department of Respiratory Diseases,the Affiliated Hospital, Luzhou Medical College,Luzhou 646000;Detection of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in serum and bronchoalveolar lavage fluid of community acquired pneumonia patients[J];Journal of Zhengzhou University(Medical Sciences);2010-06
4 HUA Shao-dong,DU Jiang,LIU Xiu-xiang,TANG Wen,YANG Li-hua,FANG Zhi-chun(Department of Pediatrics,Zhujiang Hospital Affiliated to Southern Medical University,Guangzhou 510282,China);Experimental Study of Ventilator-Induced Lung Injury and Oxygen Inhalation in Newborn Rabbits[J];Journal of Applied Clinical Pediatrics;2007-02
5 HUA Shao-dong,DU Jiang,SHI Xiao-dong,LIU Xiu-xiang,FENG Zhi-chun(Neonatal Intensive Care Unit,Bayi Children's Hospital of Beijing Army General Hospital,Beijing 100700,China);Experimental Research of Lung Injury Caused by Different Condition Mechanical Ventilation and Oxygen Inhalation in Newborn Rabbits[J];Journal of Applied Clinical Pediatrics;2008-16
6 YANG Ai-dong,WANG Dong-ying,LI Wen-wen,et al(Shanghai University of Traditional Chinese Medicine,Shanghai201203);EFFECTS OF HUJIN DECOCTION ON MMP-2mRNA AND TIMP-2mRNA EXPRESSION IN LUNGS OF RATS WITH ACUTE LUNG INJURY[J];Chinese Journal of Traditional Medical Science and Technology;2010-02
7 HUA Shao-dong, DU Jiang, ZOU Ya-wei, TANG Wen, LIU Xiu-xiang,YANG Li-hua, FENG Zhi-chun. Department of Pediatrics, Second Affiliated Hospital, Southern Medical University, Guangzhou 510282, China;Effect of lung injury and matrix metalloproteinases-2 express under different ventilation condition in newborn rabbit mechanical ventilation[J];Chinese Journal of Neonatology;2007-04
8 YANG Ai-dong,LI Wen-wen,WANG Dong-ying,et al(Shanghai University of TCM,Shanghai 201203,China);Effects of Qingrezaoshi Decoction on the Expression of MMP-2,TIMP-2 and Their mRNA in ALI Rats Caused by LPS[J];Chinese Journal of Information on Traditional Chinese Medicine;2010-08
9 ZHAN Feng,WU Rong,ZHOU Hai-yan,LI Na.(Department of Pediatrics,Chuzhou Clinical College,Anhui Medical University,Chuzhou 239000,China);Change in Pathology of Lung Tissue in Meconium-injured Newborn Rabbits Treated with Aminophylline[J];Medical Recapitulate;2010-23
【Citations】
Chinese Journal Full-text Database 2 Hits
1 LIU Xinmin, XU Song, HE Bing, et al. Respiratory Department of the First Teaching Hospital of Beijing Medical University, Beijing 100034;Effects of metalloproteinases on pulmonary fibrosis by bleomycin in rats[J];CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES;1999-02
2 Zhu Liewei, Shi Bingpei, Jin Qinli, et al. Department of Pediatrics, Shanghai Medical University, Shanghai 200032;Effect of Helium-Neon Laser on Pulmonary Surfactant in Prevention of Pulmonary Hemorrhage[J];Chinese Journal of Physical Medicine;1998-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Li Juan, Wei Kelun, Li Shuqin. Department of Pediatrics of 2nd Clinical Hospital, China Medical University, Shenyang, 110003;Changes and significance of nitric oxide and endothelin-1 in blood of newborns with pulmonary hemorrhage[J];CHINESE JOURNAL OF CONTEMPORARY PEDIATRICS;1999-01
2 CHEN Ke Zheng, WANG WeiDepartment of Neonatology, Guangzhou Children's Hospital, Guangzhou 510120, China;Pulmonary Hemorrhage Model of Neonatal Rats and Its Clinical Significance[J];Chinese Journal of Contemporary Pediatrics;2002-05
3 Du Yue, Cai Xuxu, Han Yukun. Pediatric Department, Second Affiliated Hospital, China Medical University, Shenyang 110004;The relation between the lung pathology induced by lipopolysaccharide and neonatal pulmonary hemorrhage[J];Guangdong Medical Journal;2004-01
4 HUANG Ri hong, WU Tai hua, ZHANG Zhong he (Pulmonary Department of the First affiliated hospital of Dalian Medical University, Dalian 116011);Changes of lung tissue matrix metallo proteinase and its tissue inhibitor in pulmonary fibrosis rats[J];Basic Medical Sciences and Clinics;2001-06
5 CAI Xu-xu,GAO-Fei,GAO Hong,et al.NO.2 Clinical Hospital,China Medical University,Shenyang 110004,China.;Change and significance of surfactant protein A in BALF of newborns with pulmonary hemorrhage[J];Pediatric Emergency Medicine;2005-06
6 Du Yue Cai Xuxu Wu Yubin et al Department of Pediatric of the Second Affiliated Hospital, China Medical University (Shenyang 110004);Relation between the characteristics of the lung pathology caused by lipopolysaccharide and pulmonary hemorrhage[J];Shaanxi Medical Journal;2004-04
7 DU Hui-yan1,CUI Qi-liang2.1 Department of Pediatrics,the Hospital of the Memorial of Hexian in panyu,Guangzhou Guangdong 511400,China;2 Department of Pediatrics,the Third Affiliated Hospital of Gangzhou Medical College,Guangzhou Guangdong 510150,China;The expression of aquaporin-1 and aquaporin-5 in lung tissue of pulmonary hemorrhage newborn rats[J];Journal of Clinical and Experimental Medicine;2011-04
8 YIN Jing1,YANG Li2(1.School of Clinical Medical Science,Southeast University,Nanjing 210009,China;2.Department of Pediatrics,Zhongda Hospital,Southeast University,Nanjing 210009,China);Expressions of MMP-2 and TIMP-2 in lipopolysaccharide-induced acute lung injury of neonatal rats[J];Modern Medical Journal;2009-03
9 MA Xiao-bing, CAO Jin-ling, ZHU Lan, et al. (Department of Pathology of North China Coal Medical College, Tangshan 063000, China);EFFECT OF SiO2 ON THE EXPRESSION OF MMP-1, MMP-9 AND TIMP-1 IN HUMAN ALVEOLAR MACROPHAGES AND LUNG FIBROBLASTS[J];Modern Preventive Medicine;2009-18
10 DU Yue, WU Yu-bin, CAI Xu-xu, HAN Yu-kun. Department of Pediatrics, the Second Hospital of China Medical University, Shenyang,110004, China;Changes of platelet endothelial cell adhesion molecule-1, tissue type plasminogen activator and plasminogen activator inhibitor-1 expression in the lung tissue of neonatal rats after intraperitoneal injection with lipopolysaccharide[J];Chinese Journal of Pediatrics;2004-09
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Zhou Haiyan,Wu Rong Department of Pediatrics,Chuzhou Clinical College of Anhui Medical University,Chuzhou 239000,China;Model of severe meconium aspiration in newly-born rabbits[J];Anhui Medical Journal;2010-09
2 WANG Guang-Hui1, JIN Fa-Guang1, CHU Dong-Ling1, DUAN Li2 1Department of Respiratory Diseases, Tangdu Hospital, Xi'an 710038, China, 2Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an 710033, China;Expressions of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in airway remodeling of asthmatic guinea pigs[J];Journal of the Fourth Military Medical University;2006-14
3 LI Shengli 1),DANG Yuhua 2), QIU Chunguang 2) 1)Department of Cardiology, the First People's Hospital of Shangqiu City, Shangqiu 476000 2)Department of Cardiology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Changes of serum matrix metalloproteinase-9 in patients with acute coronary syndrome[J];Journal of Zhengzhou University(Science Medical);2005-05
4 ZHANG Xiangfeng, Gao Mingzhe, Hussein D. FodaDepartment of Pulmonary Medicine, Beijing Anzhen Hospital, Beijing 100029, China(ZHANG Ziangfeng,GAO Mingzhe);Expression of matrix metalloproteinases 2 and 9 in mice with hyperoxia-induced acute lung injury[J];Journal of Emergency Medicine;2005-01
5 WANG Zhan-Fei, ZHANG Zi-Xin, ZENG Ding-Yin, and SONG Li-Xin (Department of Cardiology, the First Affiliated Hospital, China Medical University, Shenyang 110001, China);The Effect on the Expression of Matrix Metalloproteinase and Its Inhibitor of Antiplalete Medicine in Rabbits after Angioplasty[J];Chinese Journal of Arterial Lerosis;2004-06
6 LIU Wen, DONG Wen-bin (Department of neonatology, The Affiliated Hospital of Luzhou Medical College, Sichuan Luzhou 646000, China);Cytokines and meconium aspiration syndrome[J];Foreign Medical Sciences Section of Maternal and Child Health;2005-02
7 XIE Li-juan, ZHU Xiao-dong, SHEN Yi, ZHU Jian-xin, SHEN Xiao-ming (Department of Pediatrics, Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China);Role of TNF-α and IL-8 in the Inflammatory of Ventilator Induced Lung Injury in Young Rabbit Model[J];Acta Universitatis Medicinalis Secondae Shanghai;2005-04
8 RONG Zhi - hui, CHANG Li - wen , QIAN Li - ling,LI Wen - bin (Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 , China);Expression Level of Matrix Metalloproteinases, Tissue Inhibitor of Metalloproteinases and Activity of Nuclear Factor Kappa B in Different Phases of Bronchopulmonary Dysplasia[J];Journal of Applied Clinical Pediatrics;2005-05
9 GUO Ai-ling1,TIAN Pei-chao2,WANG Huai-li2,ZHUO Zhi-hong2,QIAO Xiao-hui2,CHEN Xiao-xin2(1.Department of Surgery;2.Department of Pediatrics,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China);Expression of Matrix Metalloproteinase 9 and Tissue Inhibitor of Metalloprteinase 1 in Rats with Infectious Brain Edema[J];Journal of Applied Clinical Pediatrics;2008-11
10 Kong Ying-jun, Shi Yu-zhi, Zhang Yi-mei, Huo Jian-min Department of Respiratory Medicine, First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China;Expressions of intercellular adhesion molecule and matrix metalloproteinase 2 in lung tissues of patients with chronic obstructive pulmonary diseases[J];Chinese Journal of Clinical Rehabilitation;2006-20
【Secondary References】
Chinese Journal Full-text Database 9 Hits
1 Lin Na,Zhou Haiyan Wu Rong Department of Pediatrics,Chuzhou Clinical College,Anhui Medical University,Chuzhou 239000,China;Observation of the lung pathology of meconium aspirated newborn rabbits treated by dexamethasone[J];Anhui Medical Journal;2010-10
2 Li Na,Zhou Haiyan,Wu Rong Department of Pediatrics,Chuzhou Clinical College,Anhui Medical University,Chuzhou 239000,China;Comparison of different ventilation modes on newborn rabbits with severe meconium aspiration syndrome[J];Anhui Medical Journal;2011-01
3 HUANG Jin-Jie,WU Ben-Qing,DING Lu,CHEN Li. Department of Neonatology,Shenzhen People' s Hospital,Second Clinical Medical College of Jinan University,Shenzhen,Guangdong 518020,China;Lung fibrosis induced by mechanical ventilation with different tidal volume in neonatal rats[J];Chinese Journal of Contemporary Pediatrics;2010-10
4 HUANG Jin-jie,WU Ben-qing,DING Lu(Department of Neonatology,the People′s Hospital of Shenzhen City,the Second Clinical Medical College of Jinan University,Shenzhen 518020,Guangdong Province,China);Feature of Ventilation Induced Lung Injury with Different Tidal Volume in Neonatal Rats[J];Journal of Applied Clinical Pediatrics;2010-14
5 JI Ming-li1,WANG Yu-xia1,LIU You-cai2,SI Yan-li2,WANG Jian-gang1;Expression of Tumor Necrosis Factor-α in Peripheral Blood and Bronchial Alveolarlavage Fluid in Immature Rabbits with Meconium Aspiration[J];Journal of Applied Clinical Pediatrics;2011-09
6 DONG Ke-jiang1,LI Na2,ZHOU Hai-yan2,WU Rong2. ( 1. Staff Room of Physiology,Health School of Chuzhou, Chuzhou 239000,China; 2. Department of Neonatology,Huaian Hospital for Maternal and Child Health Care,Huaian 223002,China);Observation of the Physiological Parameters in Newborn Meconium Aspirated Rabbits[J];Medical Recapitulate;2010-21
7 ZHAN Feng,WU Rong,ZHOU Hai-yan,LI Na.(Department of Pediatrics,Chuzhou Clinical College,Anhui Medical University,Chuzhou 239000,China);Change in Pathology of Lung Tissue in Meconium-injured Newborn Rabbits Treated with Aminophylline[J];Medical Recapitulate;2010-23
8 ZHAN Feng1,WU Rong1,JIN Guihong1,ZHOU Haiyan1,LI Na1,HU Bo2 1.Department of Pediatrics,Chuzhou Clinical College,Anhui Medical University,Chuzhou 239000,China;2.Department of Pediatrics,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Effects of Aminophylline on TNF-α and IL-8 levels of newborn rabbits with severe meconium aspiration[J];China Medical Herald;2011-09
9 ZHAN Feng1,HU Bo2.(1.Department of Pediatrics,Chuzhou Clinical College,Anhui Medical University,Chuzhou 239000,China;2.Department of Pediatrics,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China);Pharmacotherapy for Mconium Aspiration Syndrome[J];Medical Recapitulate;2011-15
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 Chen Kocheng;MECHANICAL VENTILATION IN THE TREATREAT OF MASSIVE PULMONARY HEMORRHAGE OF THE NFONATE[J];Guangdong Medical Journal;1991-02
2 Sun Jiae;XuJin; Zhn Liewei; WuJingyi; Jin Qinli;Chen Ruizhu; Ma Jinlog(Institute of Pediatrics, Hospital of Pediatrics, Shanghai Medical University,Shanghai Institute of Pharmaceutical Industry, Shanghai);PREVENTION OF ENDOTOXIN-INDUCED RAT LUNG INJURY WITH VITAMIN E[J];ACTA ATADEMIAE MEDICINAE SHANGHAI;1994-05
3 Liu Timon Chengyi Biology Department Liu Songhao Quantum Electronics Institute Hua'nan Normal University, Guangzhou(510631);Biophotonics on Low Intensity Laser[J];CHINESE JOURNAL OF LASER MEDICINE & SURGERY;1997-03
4 Jin Qinli, Xu Jin, Sun Jiae, et al. Children′s Hospital, Shanghai Medical University, Shanghai 200032;Pulmonary hemorrhage and pulmonary edema prevented by different formulae of phospholipids in rats[J];Chinexe Journal of Pediatrics;1997-02
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