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《Chiese Journal of Surgery》 2002-02
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Changes of immune function in liver cirrhosis patients after splenectomy combined with resection of hepatocellular carcinoma

CAO Zhixin, CHEN Xiaoping, WU Zaide Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030, China  
Objective To study the changes of immune function in liver cirrhosis patients after splenectomy combined with resection of hepatocellular circinoma (HCC). Methods Sixteen patients with HCC associated with liver cirrhosis were divided into two groups: splenectomy combined with hepatectomy ( n =7) and hepatectomy ( n =9). T lymphocyte subsets such as CD4, CD8, CD4/CD8 and Th lymphocyte cytokines such as IFN γ, IL 2, IL 10 in 7 ml peripheral venous blood before operation and two months after operation were examined and compared between the two groups. Results There was no significant difference in pre operative CD4, CD4/CD8, IL 2, IFN γ, IL 10 levels in the two groups. Two months after operation, the levels of CD4 (38 2%±3 7%), CD4/CD8 (1 7±0 3), IFN γ [(104 4±14 9)pg/ml], IL 2[(98 6±18 6)pg/ml] were increased and those of CD8 (23 7±13 7)pg/ml and IL 10 [(55 5±11 2)pn/ml] were decreased in the two groups, but the changes in the group of splenectomy combined with hepatectomy were more obvious than those in the hepatectomy group. The levels of CD4 (32 5%±4 0%),CD4/CD8 (1 1±0 1), IFN γ [(70 5±12 6) pg/ml], IL 2 [(80 9±13 5)pg/ml] in the group of splenectomy combined with hepatectomy, were much higher than those in the hepatectomy group; those of CD8 (29 4%±4 0%), IL 10 [(89 4±10 0)pg/ml] level were significantly lower than those in the hepatectomy group ( P 0 05). Conclusion Splenectomy combined with hepatectomy for HCC associated with liver cirrhosis donot decrease but promote the recover T lymphocyte subsets and Th1/Th2 cytokines from imbalance and improve the patient′s antitumor immune function.
【Fund】: 卫生部科研基金资助项目 ( 941136)
【CateGory Index】: R735.7
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