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《Chinese Journal of Surgery》 2004-16
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Effects of sevoflurane on membrane permeability of alveolar capillaries in rats with acute lung injury caused by endotoxin

SUN Yan hong,ZHANG Qian,WANG Jun ke,CUI Yong Department of Anesthesiology,First Affiliated Hospital of China Medical University,Shenyang 110001,China  
Objective To observe the effect of sevoflurane on membrane permeability of alveolar capillaries in rats with acute lung injury and the ratio of inflammatory cells in bronchoalveolar lavage fluid in rats with acute endotoxin lung injury Methods 48 Wistar rats were selected and divided into group C,L,S1L and S2L after injection evans blue 50 mg/kg in random with 12 rats in each group Group C was taken as control group,1 2 ml normal saline was injected into the rats via femoral vein and then the rats were mechanically ventilated for 4 hours; The rats in group L were also mechanically ventilated for 4 hours after injection of endotoxin 5 mg/kg via the same vein For the rats in group S1L and S2L,1 0 or 1 5 minimal alveolar concentration (MAC) sevoflurane was inhalated with mechanical ventilation after injection of endotoxin 5 mg/kg Evans blue was not injected into 6 rats of each group in order that the 6 rats could be used for pathological examination and alveoli lavage,lung pathomorphological score of the lung,lung wet/dry weight ratio,the content of lung water,lung permeability index,content of evans blue,total amount and ratio of inflammatory cells in bronchoalveolar lavage fluid (BALF) were all determined Results Sevoflurane of 1 0 MAC and 1 5 MAC made lung wet/dry weight ratio and content of lung water change insignificanly; lung permeability index,content of evans blue and pathomorphological score in group S1L decreased from 4 86±0 82,112 21±11 44 ng/mg,9 17±0 90 to 3 98±0 50,92 85±11 80 ng/mg,7 50±0 96; group S2L decreased to 3 91±0 34,96 33±8 79 ng/mg,7 67±0 75 Sevoflurane of 1 0 MAC and 1 5 MAC did not have a significantly effect on total amount and ratio of inflammatory cells in BALF Conclusion Membrane permeability of alveolar capillaries after acute endotoxin lung injury decreased by inhalation of sevoflurane of 1 0 MAC and 1 5 MAC and pathological injury of lung tissue relieved
【CateGory Index】: R96
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Chinese Journal Full-text Database 8 Hits
1 SHANG GUAN Wang-ning LIU Jin Department of Anesthesiology,West China Hos-pital,SiChuan University,Chengdu 610041 ,China;The effects of inhaled anesthetics on lung[J];International Journal of Anesthesiology and Resuscitation;2007-04
2 ZHAO Shuangping,WU Jiao,GUO Qulian,ZHANG Zhong,YE Zhi(Intensive Care Unit,Xiangya Hospital,Central South University,Changsha 410008,China);Effect of different concentrations of sevoflurane pretreatment on acute lung injury induced by endotoxin in rats[J];Journal of Central South University(Medical Science);2010-09
3 SHANGGUAN Wang-ning, XIANG Yong, LIU Jin. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China;The Effect of Pulmonary Static Inflation with Sevoflurane During Cardiopulmonary Bypass on Lung Function in Patients Undergoing Cardiac Valve Replacement Surgery[J];Journal of Sichuan University(Medical Science Edition);2008-05
4 WANG Haihong,MA Xiaoxu.Department of Anesthesiology,Sir Run Run Shaw Hospital,school of Medicine,Zhejiang University,Hangzhou 310016,China;Effects of sevoflurane on IL-1β level of human monocytic cell line THP-1 induced by lipopolysaccharide[J];Clinical Education of General Practice;2012-01
5 CANG Jing, WANG Li-jun, XUE Zhang-gang(Department of Anesthesiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China);Effects of combined sevoflurane-epidural anesthesia on inflammatory factors in rabbits with hypoxic lung injury[J];Fudan University Journal of Medical Sciences;2009-02
6 Zhang Shubo,Li Baoyong,Gao Xiaozeng,et al.Department of anaesthesia,hebei united university afiliated hospital,Tangshan 063000,China;THE PROTECTIVE EFFECTS OF SEVOFLURANE ON LUNG ISCHEMIA REPERFUSION INJURY IN RATS[J];Chinese Journal of Coal Industry Medicine;2011-08
7 ZHAO Shuang-ping,WU Jiao,GUO Qu-lian,CHEN Sheng-xi(ICU,Xiangya Hospital,Central South University,Changsha,Hunan 410008,P.R.China);Effects of sevoflurane alleviating LPS-induced acute lung injury by increasing HO-1 expression[J];China Journal of Modern Medicine;2010-16
8 LI Yongle AN Haishui DENG Mo WU Guangyi Department of Anaesthesia, the Affiliated Hospital of Hebei University, Baoding 071000, China;Protective effects of sevoflurane for acute lung injury by LPS of rat[J];China Modern Medicine;2013-11
Chinese Journal Full-text Database 2 Hits
1 LI Qi 1, QIAN Gui-sheng 1, ZHANG Qing 1, TANG Zheng-cai 2, GAO Zheng-jin 2 (?1 ?Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; ? 2?Respiratory Department of 324th Hospital, Chongqin;Changes of IL-10 mRNA expression and activator protein-1 activity in lung of rats with SIRS-acute lung injury induced by lipopolysaccharides[J];Chinese Journal of Pathophysiology;2002-08
2 Lei Wenzhang,etal.Department of furgery,First AffiliatedHospital,West China University of MedicalSciences,Chen dou 610041.;The relationship between the endotoxemiaand damages to multiple organs in the experimental necrotic pancreatitis[J];CHINESE JOURNAL OF EXPERIMENTAL SURGERY;1995-03
Chinese Journal Full-text Database 10 Hits
1 YAO Li-jun1,SHI Jing-li2,LV Ming-zhuang3,HE Zhi-guang3,QIN Ren-an3(1Hospital of Southwest University,Chongqing 400715,China;2The Fifth Affiliated Hospital of Zhongshan University,Zhuhai 519000,China;3Guiyang Medical University,Guiyang 550004,China);Effect of Yinhua Agent on expression of c-fos proto-oncogene in the hippocampus and content of IL-1β after acute lung injury in CA2-3 regoin of rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2012-03
2 FEI Mao-yun,FENG Wen-ming,BAO Ying,ZHU Ming,TAO Yu-long,WANG Yong-chun,ZHANG Xiao-lan,JIANG Xiao-ying (Department of Surgery,the First Hospital of Huzhou,Huzhou 313000,Zhejiang,China);Effects of enteral nutrition on glucocorticoid receptor and heat shock protein 70 in severe acute pancreatitis in rats[J];Parenteral & Enteral Nutrition;2007-05
3 Yang Mei Feng Xianqiong Li Guixiang et al;Observation on the clinical effect of insertion length of enema tuber with Traditional Chinese medicine for treatment of acute pancreatitis[J];Journal of Nurses Training;2004-04
4 Cheng Guozuo,Zhang Jianxin,Li long,et al.Department of General Surgery,The Affiliated Hospital of Jiangsu University,Zhenjiang 212001;THE CHANGES OF RENAL DAMAGE AND MICROCIRCULATION IN RATS WITH ACUTE NECROTIZING PANCREATITIS.[J];Journal of Hepatobiliary Surgery;2002-04
5 DONG Rui,WANG Zi-fa,LV Yi,et al.Department of General Surgery,Tangdu Hospital,The Fourth Military Medical University,Xi'an 710038,China);TREATMENT OF SEVERE ACUTE PANCREATITIS WITH LARGE DOSAGE OF DEXAMETHSONE IN THE EARLIER TIME.[J];Journal of Hepatobiliary Surgery;2005-01
6 XIA Qing *,YANG Xiao-nan,GONG Xu,et al. * Integrated Department of Traditional Chinese Medicine and Western Medicine,Huaxi Hospital of Sichuan University,Chengdu 610041;Study on mechanisms of lung injury during acute necrotizing pancreatitis[J];Journal of Hepatopancreatobiliary Surgery;2004-01
7 BAO Ying,FENG Wenming,ZHU Ming,et al. Department of Surgery, the First People's Hospital of Huzhou,Huzhou Zhejiang 313000;Expression of glucocorticoid receptor and heat shock protein 70 in severe acute pancreatitis in rats[J];Journal of Hepatopancreatobiliary Surgery;2007-04
8 LIU Shuai,ZHANG Qi-yu,CHEN Bi-cheng,et al.Department of Hepatobiliary Surgery,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000;The mechanism of the intervention effect of sivelestat sodium in the treatment of the rats with acute pancreatitis associated lung injury[J];Journal of Hepatopancreatobiliary Surgery;2011-02
9 Niu Guijun,Tang Guodu,Liang Zhihai,et al.(Department of Digestion,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021China);EXPRESSION OF TRX-1 IN RAT LUNGS WITH ACUTE NECROTIZING PANCREATITIS[J];Journal of Guangxi Medical University;2010-03
10 YANG Hui-ying,SU Juan,TANG Guo-du,QIN Meng-bin,LIANG Zhi-hai,ZHONG Wei-yi(Department of Gastroenterology,First Affiliated Hospital,Guangxi Medical University,Nanning 530021,China);Roles of Ghrelin in Severe Acute Pancreatitis Associated with Kidney Injury[J];Guangxi Medical Journal;2010-07
China Proceedings of conference Full-text Database 2 Hits
1 ;脂多糖刺激前后小鼠肺肝脾组织中TLRs等受体的基因表达情况[A];[C];2006
2 Liu SiQing, Cao LiYin, Wang BaoQiang, et al. Department of Hepatobiliary Surgery, Affiliated Kai-Luan Hospital, North China Coal Medical College. TangShan, 063000;Protection by DanYiHeWei Granule against Lung Injury during Early Severe Acute Pancreatitis[A];[C];2005
Chinese Journal Full-text Database 10 Hits
1 ZHANG Xiao-hua1,ZHANG Lan2(1.Chinese Traditional and Western Medicine Hospital,2.Second Affiliated Hospital,Wenzhou Medical School,Wenzhou,Zhejiang 325000);Protective effect of puerarin agaist cerebral ischemia-reperfusion injury in rats[J];Anhui Medical and Pharmaceutical Journal;2007-08
2 SHAO Da-rong,XU Lian-bao,YIN Wei-bing,DING Xin-sheng (Department of Neurology,the First Affiliated Hospital,Nanjing Medical University,Nanjing 210029);Neuroprotective effects of batroxobin combined with edaravone in treatment of cerebral ischemic reperfusion injury in gerbils[J];Anhui Medical and Pharmaceutical Journal;2007-11
3 GENG Zhiyu △, SHAN Guojin, SONG Linlin, XU Xing, WU Xinmin (Department of Anesthesiology, Peking University First Hospital, Beijing 100034, China);Target-controlled infusions of remifentanil and propofol during laparoscopic cholecystectomy[J];Journal of Peking University(Health Sciences);2003-05
4 WANG Chunyan, ZHAO Zhongxin, XIA Bin Department of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;Expressions of ICAM-1 and VCAM-1 associated with ischemia-reperfusion brain injury[J];Chinese Journal of Neuromedicine;2003-06
5 Kazuyoshi Kuwano ,Division of Respiratory Diseases,Department of Internal Medicine,Jikei University School of Medicine,Tokyo,Japan;;Epithelial Cell Apoptosis and Lung Remodeling[J];中国免疫学杂志(英文版);2007-06
6 WANG Jian-chun1, JIANG Peng2, HUANG Jian3, QIAN Gui-sheng1 (1Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, 2Urumchi General Hospital of Lanzhou Military Command, Urumchi Xinjiang 830000, 3Department of Respiratory Diseases, Chongqing Armed Police Hospital, Chongqing 400061, China);PPARγ expressions in rat lung tissues after acute lung injury[J];Acta Academiae Medicinae Militaris Tertiae;2008-06
7 TAN Xing-qin1, CHEN Yu-pei1, ZHANG Wen-sheng2, LIU Jin2 (1Department of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, 2Laboratory of Anesthesiology & Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China);Effect of emulsified isoflurane on myocardial apoptosis and expressions of bcl-2 and bax induced by hypoxia-reoxygenation[J];Acta Academiae Medicinae Militaris Tertiae;2008-17
8 HOU Li Chao 1, ZHANG Hong 2, XIONG Li Ze 1, HU Wen Neng 1, ZENG Xiang Long 1 1Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China, 2Department of Anesthesiology, General Hospital of;Comparative study of effects of sevoflurane and isoflurane on cardiovascular system[J];Journal of The Fourth Military Medical University;2000-11
9 WU Ming Chun, XIONG Li Ze, ZHU Zheng Hua, HOU Li Chao, ZHENG Yu, SANG Han Fei Department of Anaesthesiology, Xijing hospital, Fourth Military Medical University, Xi'an 710033, China;Dose-response effects of isoflurane preconditioning to induce ischemic tolerance in transient middle cerebral artery occlusion model in rats[J];Journal of The Fourth Military Medical University;2002-15
10 QU Shuo-Yao,OUYANG Hai-Feng,TI Xin-Yu,XUE Yan,WU Chang-Gui Department of Respiratory,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China;Construction of adenoviral expression vector carrying FLIP gene and its expression in rat pulmonary vascular endothelial cells[J];Journal of the Fourth Military Medical University;2009-18
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 LI Yongle AN Haishui DENG Mo WU Guangyi Department of Anesthesia,Affiliated Hospital of Hebei University,Baoding 071000,China;Protective effect of different concentrations of sevoflurane on acute lung injury rats[J];China Medicine and Pharmacy;2013-06
2 TUO Ya,SONG Jing-hui,FAN Feng-qing(The Affiliated Hospital of Inner Monglia Medical College,Huhoot 010059.China);Effects of Gynecologic Laparoscopy on Blood Sfagnate and Ischemical Reperfusion Injury of Human Body[J];Journal of Diseases Monitor & Control;2012-03
3 SU Jian-lin,LIU Bing,YANG Zi-hua,et al.Department of Anesthesiology,People's Hospital of Guilin,Guilin 541002,China;Protective role of sevoflurane in the function of myocardium and lung in patients undergoing coronary artery bypass grafting under cardiopulmonary bypass[J];The Journal of Clinical Anesthesiology;2011-03
4 GAO Ya-li,ZHOU Wei-de,ZHOU Ling,SHU Shu-hua,FANG Cai(Department of Anesthesiology,Anhui Provincial Hospital,Hefei 230001,China);Evaluation of bispectral index and auditory evoked potential index for monitoring the depth of sevoflurane anesthesia in the elderly[J];Chinese Journal of Clinical Healthcare;2011-04
5 HUANG Jian-bo;HUANG Qiang;TU Su-lan;Department of Anesthesiology,the Second People's Hospital of Jiangmen;;Effect of epidural block combined with general anesthesia on serum IL-2, IL-4 levels in patients with gastric cancer after operation[J];Hainan Medical Journal;2013-18
6 WANG Dong-xin;HOU Wen-jie;DIAO Shi-qi;KAN Hong-li;Department of Anesthesiology,Jilin Province Tumor Hospital;;Effect of sevoflurane preconditioning on inflammatory cytokines and oxygen radicals during one lung ventilation in patients with lung cancer[J];Journal of Clinical Anesthesiology;2013-09
7 QI Xiang,XU Xue,ZHANG Hui-jun,LIANG Zhi,LIU Yue,DONG Zhen-ming(Department of Anesthesiology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,Heibei,China);Effect of Sevoflurane or Propofol on Cerebral Oxygen Metabolism during One-lung Ventilation[J];Chinese Journal of Modern Operative Surgery;2010-05
8 LI Fang,QU Qiang(Hejiang County People's Hospital,Hejiang,Sichuan 646200,China);Effect of PEEP on lung compliance and respiratory index in patients after open heart surgery with cardiopulmonary bypass[J];Modern Medicine & Health;2009-15
9 LI Yu,ZHANG Jian-fu.(Department of Physiology,Xuzhou Medical College,Xuzhou 221002,China);Study Progress on Pharmacological Postconditioning[J];Medical Recapitulate;2009-21
10 SUN Yan-hong,CUI Yong,WANG Jun-ke,PEI Ling(Department of Anesthesiology,First Affiliated Hospital of China Medical University,Shenyang 110001,China);Effect of sevoflurane on pulmonary ICAM-1 and TNF-α after acute lung injury induced by endotoxin in rats[J];Chinese Journal of New Drugs;2011-22
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
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