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《Chinese Journal of Surgery》 2004-16
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Effects of sevoflurane on membrane permeability of alveolar capillaries in rats with acute lung injury caused by endotoxin

SUN Yan hong,ZHANG Qian,WANG Jun ke,CUI Yong Department of Anesthesiology,First Affiliated Hospital of China Medical University,Shenyang 110001,China  
Objective To observe the effect of sevoflurane on membrane permeability of alveolar capillaries in rats with acute lung injury and the ratio of inflammatory cells in bronchoalveolar lavage fluid in rats with acute endotoxin lung injury Methods 48 Wistar rats were selected and divided into group C,L,S1L and S2L after injection evans blue 50 mg/kg in random with 12 rats in each group Group C was taken as control group,1 2 ml normal saline was injected into the rats via femoral vein and then the rats were mechanically ventilated for 4 hours; The rats in group L were also mechanically ventilated for 4 hours after injection of endotoxin 5 mg/kg via the same vein For the rats in group S1L and S2L,1 0 or 1 5 minimal alveolar concentration (MAC) sevoflurane was inhalated with mechanical ventilation after injection of endotoxin 5 mg/kg Evans blue was not injected into 6 rats of each group in order that the 6 rats could be used for pathological examination and alveoli lavage,lung pathomorphological score of the lung,lung wet/dry weight ratio,the content of lung water,lung permeability index,content of evans blue,total amount and ratio of inflammatory cells in bronchoalveolar lavage fluid (BALF) were all determined Results Sevoflurane of 1 0 MAC and 1 5 MAC made lung wet/dry weight ratio and content of lung water change insignificanly; lung permeability index,content of evans blue and pathomorphological score in group S1L decreased from 4 86±0 82,112 21±11 44 ng/mg,9 17±0 90 to 3 98±0 50,92 85±11 80 ng/mg,7 50±0 96; group S2L decreased to 3 91±0 34,96 33±8 79 ng/mg,7 67±0 75 Sevoflurane of 1 0 MAC and 1 5 MAC did not have a significantly effect on total amount and ratio of inflammatory cells in BALF Conclusion Membrane permeability of alveolar capillaries after acute endotoxin lung injury decreased by inhalation of sevoflurane of 1 0 MAC and 1 5 MAC and pathological injury of lung tissue relieved
【CateGory Index】: R96
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