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《Chiese Journal of Surgery》 1996-11
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AnexperimentalstudyontheanticancerouseffectsofCD3┐TILderivedfromhumanprimaryhepaticcarcinoma

LiAijun,WuMengchao,ShengFeng,etal.EasternHepatobiliarySurgeryHospital,SecondMilitaryMedicalUniversity,Shanghai200433.  
Inthisstudy,CD3-TILproducedbyinvitroinductionwithCD3andIL-2(CD3-TIL)wascomparedwithTILstimulatedbyonlyIL-2(TIL)intheirinvitroproliferation,andbothinvitroandinvivoanticancerousefects.ItwasfoundthatCD3attheconcentrationof100ng/mlwasthemostsuitablestimulusofinvitroTILproliferation(CD3-TIL)whichwassignificantlygreaterthanthatbysimpleIL-2stimulation.AlsoinvitroanticancerousactivityofCD3-TILwasgreaterthanTIL.CD3-TILsignifi-cantlyinhibitedtumorgrowth,causingshrinkageoftumormass,andprolongingthelifespanofthenudemousewithtumorburden.
【CateGory Index】: R730.51
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