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Congenital Megacolon and Cytomegavirus Infection in Infants

Wang Lianying; Li Zheng; RuanQiang;( Pediat.Surg.,2 nd Affiliated Hospital,China Medical University, Shenyang 110003)  
To understand the relation between congenital megacolon and cytomegalovirus(CMV)infection in infants,nineteen infants with megacolon(confirmed by pathological examination)were studied.Their ages ranged from 2 to 18 months. CMV was detected in the blood,urine and pathological specimen by virus isolation and DNA needle hybridism. The results were as follows:two urine samples were contaminated, seven were postitive( 4 1.2%)V.S.14.4%positive in normal(P0.05). In the 2 of 19 serum samples in HD children, CMV IgM antibodies were positive(10.5%),V.S. 8.0%in normal serum samples(P 0.05%).In 19 spastic segment tissue masses of HD,none was positive in CMV detection, 6 were positive in CMV-DNA needle hybridism,2 strongly positive(100%).These indicate that HD is closely related to CMV infection. CMV infection may be an important teratological factor of some congenital malformations including HD.
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