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《CHINESE JOURNAL OF PEDIATRIC SURGERY》 1998-04
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The Effect of Preoperative Chemotherapy on Apoptosis and Proliferation of Neuroblastoma Cells

Gao Jiechun, Qian Baoping, Jin Baixiang. Department of Surgery, Children's Hospital, Shanghai Medical University, Shanghai 200032  
Objective: To evaluate the effect of preoperative chemotherapy on apoptosis and proliferation of neuroblastoma cells. Methods: Tumor cells were immunostained with terminal deoxytransferase mediated biotin DUTP nick end labeling (TUNEL) and proliferating cell nuclear antigen (PCNA). The indices of apoptosis, proliferation and mitosis of the chemotherapeutic group (receiving preoperative chemotherapy) were compared to those of the nonchemotherapeutic group (undergoing operation only). Results:Immunostaining with TUNEL revealed no significant difference between the chemotherapeutic and nonchemotherapeutic groups (9.17±4.88 vs 10.11±5.16, P0.05). Immunostaining with PCNA showed that the proliferation index of the chemotherapeutic group was significantly lower than that of nonchemotherapeutic group (18.00±9.55 vs 29.00±13.80, P0.05) and the mitosis index of the chemotherapeutic group was also lower than that of the nonchemotherapeutic group (1.67±1.34 vs 3.67±2.24, P0.05). Conclusions: Preoperative chemotherapy is effective in suppressing tumour cells proliferation. Immunostaining with TUNEL and PCNA is useful in monitoring the apoptosis and mitosis of tumour cells.
【CateGory Index】: R730.264,R73-361
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