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《Chinese Journal of Cardiology》 2006-04
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Research of L-type Ca~(2+) channel current in atrial myocytes of patients with chronic atrial fibrillation

LI Miao-ling, ZENG Xiao-rong, YANG Yan, LIU Zhi-fei,ZHOU Wen,DING Yin-yuan, PEI Jie. Department of Myocardial Electrophysiology, Institute of Cardiovascular Research, Luzhou Medical College, Luzhou 646000, China  
Objective To investigate the changes of L-type Ca~ 2+ channel current (I_ Ca-L ) and its voltage-dependent activation and inactivation in atrial myocytes of patients with atrial fibrillation (AF). Methods The specimens of right atrial appendage were obtained from 18 patients with normal sinus rhythm (NSR) and 12 patients with chronic atrial fibrillation (CAF). Single myocytes were isolated by enzymatic dissociation with two-step method and the ionic currents were recorded using whole-cell patch clamp techniques to detect the changes of I_ Ca-L density and kinetic properties. Results (1) I_ Ca-L density was (-1.32± 0.19) pA/pF in CAF group (n=12) and (-4.58±0.39 )pA/pF in NSR group (n=21) at the test potential from -40 mV to 0 mV. I_ Ca-L density of CAF group was significantly reduced (P0.01), compared with the NSR group. (2) No significant differences were noted between the two groups in the voltage-dependent activation parameters (V_ 1/2 , K) and inactivation parameters (V_ 1/2 , K). Conclusions I_ Ca-L density of CAF group was significantly decreased whereas it′s voltage-dependent kinetic properties had no change. This phenomenon may be one of the mechanisms of atrial electrophysiological remodeling in chronic atrial fibrillation.
【Fund】: 教育部重点资助项目(03109)
【CateGory Index】: R541.75
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Chinese Journal Full-text Database 8 Hits
1 Zhao Chaoren,Zhou Huafu,Feng Xun,Li Yi,Qian Jun,Xu Xianzeng.(Department of Cardiothoracic Suegery,the First Hospital Affiliated of Guangxi Medical University,Nanning 530021,China);THE DIVERSIFICATION OF ATRIAL MYOCYTEIN ACTION POTENTIAL IN PATIENTS WITH ATRIAL FIBRILLATION[J];Journal of Guangxi Medical University;2011-01
2 QI Guo-qing,WEI Li-ye,LI Yong-xing,XIA Yue,LI Qing-wei,CHEN Xue-lingDepartment of Cardiology,the First Hospital of Hebei Medical University,Shijiazhuang 050031,China;Effects of losartan on L-type calcium channel in rapid atrial pacing in rabbits[J];Clinical Focus;2008-18
3 WEI Liye1 XIA Yue1 QI Guoqing1 LI Yongxing2(1Department of Cardiology,the First Affiliated Hospital of Hebei Medical University,Shijiazhuang,050031,China;2Department of Medicine,the Central Hospital of Cangzhou in Hebei);Effects of losartan on atrial electrical remodeling and L-type calcium channel in rabbits by rapid atrial pacing[J];Journal of Clinical Cardiology;2009-01
4 LI Miao-Ling ZENG Xiao-Rong~* YANG Yan LIU Zhi-Fei DING Yin-Yuan ZHOU Wen PEI Jie Department of Myocardial Electrophysiology,Luzhou Medical College,Luzhou 646000,China;An improved method for isolation of single atrial myocyte from human heart[J];Acta Physiologica Sinica;2007-06
5 WANG Fang-fang XU Yan-min Institute of cardiovascular Diseases,The Second Hospital,Tianjin Medical University,Tianjin 300211,China;The relationship of L type calcium channel and atrial remodeling[J];Chinese Journal of Cardiovascular Medicine;2007-03
6 ZHOU Xue-jun,DING Zhi-jian(Department of Cardiology,The Second Hospital of Changzhou Affiliated to Nanjing Medical University,Changzhou 213000,China);Atrial Refractory Period Dispersion and Atrial Fibrillation[J];Advances in Cardiovascular Diseases;2010-05
7 LIU Gan,CHEN Yun-qing.(Department of Cardiology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China);Atrial Ca~(2+) Homeostasis in the Mechanism of Atrial Fibrillation[J];Medical Recapitulate;2011-04
8 XU Kai,ZHANG Jia-wei(Department of Clinical Medicine,Shuqing Medical College,Zhengzhou,Henan 450064,China);Ion-channel remodeling mechanism in atrial fibrillation[J];Modern Medicine & Health;2011-11
Chinese Journal Full-text Database 1 Hits
1 ZHANG Jiancheng *,HUANG Congxin,DENG Yulian,et al. *Department of Cardiology, Fujian Provincial Research Institute for Cardiovascular Diseases, Fuzhou 350001, China;Molecular basis of alteration of L-type calcium channel current in patients with atrial fibrillation[J];Chinese Journal of Cardiology;2002-08
Chinese Journal Full-text Database 9 Hits
1 Wang Xiaohu ,Den Yulian,Zhang Jianchen,et al. Fujian Provincial Hospital,Fujian 350001,China;Molecular basis of I_(k1) remodeling in patients with atrial fibrillation[J];Fujian Medical Journal;2003-02
2 Ya-Zhou LIN~1, Chun-Xuan XU~1, Yu-Lian DENG~1, Lin CHEN~1, Hai HUANG~2, Jian DU~2(1. Department of Cardiology, FujianProvincial Research Institute for Cardiovascular Diseases, Fujian Provincial Hospital, Fuzhou, Fujian Province 350001, China; 2. Department of Traditional Chinese Medicine, Fujian College of Traditional Chinese Medicine, Fuzhou, Fujian Province 350001, China);Effects of tetramethylpyrazine on fibrosis of atrial tissue and atrial fibrillation in a canine model of congestive heart failure induced by ventricular tachypacing[J];Journal of Chinese Integrative Medicine;2006-01
3 WANG Qiong 1, REN Wei-hua 2, JIA Guo-liang 1, TSE Hung-fat 3, LAU Chu-pak 3 (1.Department of Cardiology, Xijing Hospital, Xi'an,Shaanxi,710032, China; 2.Department of Health, Command School of Frontier Armed Police, Guangzhou; 3.Division of Cardiology, Queen Mary Hospital, University of Hong Kong, Hong Kong);Effect of Verapamil on burden of atrial fibrillation in patients implanted with an implantable atrial defibrillator[J];Chinese Heart Journal;2003-04
4 TAN Li-hong~1,JIANG Jin-fa~2 (1.Department of Clinic,The 455th Hospital of PLA,Shanghai 200052,China;2.Department of Cardiology,Tongji Hospital Affiliated to Tongji University,Shanghai 200065,China);The Relationship Between Atrial Fibrillation and Atrial Natriuretic Peptide or Ventrioatrial Conduction in VVI Paced Patients[J];Advances in Cardiovascular Diseases;2006-05
5 WU Jia-bin, XU Chun-xuan, ZHANG Jian-cheng, CHEN Lin, LIN Li-fang, HU Xi-zhong Department of Internal Medicine, Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, Fujian, China; 1 Fujian Provincial Research Institute of Cardiovascular Diseases, Fuzhou 350001, Fujian, China;Study of chloride channel ClC-3 gene expression in patient with atrial fibrillation[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2005-06
6 PANG Lun-xiang,HE Jing-song,LIU Jun-chao.(Department of Cardiology,Rui Kang Hospital Affiliated to Guangxi College of Traditional Chinese Medicine,Nangning 530011,China);Progress of Ion Channel Remodeting in Atrial Fibrillation[J];Medical Recapitulate;2007-02
7 LIN Ya-zhou CHEN Lin XU Chun-xuan DENG Yu-lian WU Xiao-dan CHEN Bin HU Xi-zhong Department of Cardiology,Fujian Provincial Research Institute for Cardiovascular Diseases,Fuzhou 350001,China;Relationship between collagen Ⅰ,MMP-2 and TIMP-2 gene expression and atrial fibrosis and fibrillation during heart failure in dogs.[J];Chinese Journal of Geriatrics;2006-02
8 CHENG Kangan, DENG Hua, FANG Quan, et al. Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China;Experimental study of calcium on atrial electrical remodeling[J];Chinese Journal of Cardiology;2001-02
9 Lin Yazhou,Xu Chunxuan,Huang Hai,et al // Research Institute for Cardiovascular Diseases of Fujian(Fuzhou 350001);The mRNA Expression of Collagen I,IV and TGF-β_1 in Canine Atrium by Prevention of Tetramethylpyrazine during Congestive Heart Failure[J];Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease;2005-06
Chinese Journal Full-text Database 10 Hits
1 CHEN Xia 1,LI Ying ji 2,ZHANG Wen jie 2,GE Jing yan 2,ZHONG Guo gan 2 (1 Dept of Pharmacology,Shool of Basic Medical Sciences,Jilin University,Changchun 130021 China; 2 Department of Physiology,School of Basic Medical Sciences,Jilin Universit;Effects of oxymatrine on sodium current in isolated ventricular cells in guinea-pig[J];Journal of Norman Bethune University of Medical Science;2001-01
2 LIU Jie,DENG Jian-xin,PAN Bing-xing,HUANG Qiao-bing Department of Pathophysiology,Southern Medical University,Guangzhou 510515,China;KCNE2 modulates the function of Kv4.3 channel[J];Journal of Southern Medical University;2006-12
3 Wang Xiaohu ,Den Yulian,Zhang Jianchen,et al. Fujian Provincial Hospital,Fujian 350001,China;Molecular basis of I_(k1) remodeling in patients with atrial fibrillation[J];Fujian Medical Journal;2003-02
4 Ji Jian Qiu Jianqiang Huang Yanping, et alThe 303 Hospital of PLA 530021;Clinical Significance and Effect of Ciwujia Injection on QT Interval Dynamicity of the Patient with Arrhythmia due to Coronary Heart Disease[J];Guangxi Journal of Traditional Chinese Medicine;2002-02
5 Chen Jiangbin, Huang Congxin, Tang Qizhu, et al (The Laboratory of Cardiovascular Diseases,First Affiliated Hospital,Hubei Medical University,Wuhan 430060,China);Electrophysiologic Effect of Trtramethylpyrazine on Ventricular Myocardium[J];JOURNAL OF HUBEI MEDICAL UNIVERSITY;1999-02
6 LIU Hong, QI Min, HU Xiangjie, ZHANG Guiqing Department of Pharmacology, Zhengzhou University, Zhengzhou 450052;Effects of Zaoboning Chongji on experimental arrhythmia[J];Journa of Henan Medical University;2002-05
7 Ma Long People's Hospital of Shangcai County;Chinese Medicines in the Treatment of Arrhythmia Due to Coronary Heart Disease[J];Journal of Henan College of Traditional Chinese Medicine;2003-03
8 Li Fang et al (Department of Pathophysiology);Protection of Carthamfutinctorius on Transmembrane Potentials in Papillary Myocardium of Guinea Pig under Anoxia and Reoxygenation[J];JOURNAL OF HARBIN MEDICAL UNIVERSITY;1999-01
9 HU Ji-ying, YANG Wen, PAN Ke-ying, LI Mei-ping (Hubei College of TCM, Wuhan 430061);The Effects of Gancaosanshen Mixture on NOS and NO of Rats in Myocardial Ischemia-reperfusion Arrhythmia[J];Journal of Hubei College of Traditional Chinese Medicine;2005-03
10 SHANG Shu-yu1,HAN Sheng-na1,JING Ying1,CHENG Shu-mo1,QIAO Peng1,Zhang Zhao2*(1.Department of physiology,Basic Medical College,Zhengzhou University,Zhengzhou 450052;2.Jiangsu Province the Key Laboratoryfor Molecular Medical Biotechnology,College of Life Science in Nanjing Normal University,Nanjing 210046,China);Prolongation of cardiac action potential duration induced by antofloxacin in isolated guinea pig papillary muscles[J];Basic & Clinical Medicine;2008-07
【Secondary References】
Chinese Journal Full-text Database 7 Hits
1 Zhao Chaoren,Zhou Huafu,Feng Xun,Li Yi,Qian Jun,Xu Xianzeng.(Department of Cardiothoracic Suegery,the First Hospital Affiliated of Guangxi Medical University,Nanning 530021,China);THE DIVERSIFICATION OF ATRIAL MYOCYTEIN ACTION POTENTIAL IN PATIENTS WITH ATRIAL FIBRILLATION[J];Journal of Guangxi Medical University;2011-01
2 Wang Yongxia,Zou Zhinuan,Zhu ChulinNo.1 Affiliated Hospital of Henan College of Chinese Medicine,Zhengzhou,Henan,China 450000;Revealing the Mechanism of Drug Action from Patchclamp Technique with Serum Pharmacology[J];China Journal of Chinese Medicine;2010-04
3 LIU Xing XU Yanmin LI Guangping XU Gang CHEN Xin (Department of Cardiology,the Second Hospital of Tianjin Medical University,Tianjin,300211,China);Prevention of new occurred atrial fibrillation in coronary heart disease patients with heart failure by angiotensin converting enzyme inhibitors[J];Journal of Clinical Cardiology;2010-11
4 Lei Ming,et al Institute of Myocardial Electrophysiology,Luzhou Medical College;THE ESTABLISHMENT OF AN INTRACELLULAR FREE CA~(2+) CONCENTRATION MEASURING SYSTEM[J];Journal of Luzhou Medical College;2010-05
5 Li Tao,Li Miaoling,Lei Ming,Tan Xiaoqiu,Ding Yinyuan,Yang Yan,Zeng XiaorongDepartment of Electrophysiology,Institute of Cardiovasology,Luzhou Medical College;AN EFFECTIVE METHOD OF RECORDING SMALL CONDUCTANCE Ca~(2+)-ACTIVATED K~+ CHANNELS IN HUMAN ATRIAL MYOCYTE[J];Journal of Luzhou Medical College;2011-01
6 ZHAO Ji-zhong,ZHANG He-gong(Hospital of Shandong Laiwu Steel Co.,Ltd.,Laiwu 271126);Advances in research of AngiotensinⅡ AT_1 receptor blockers[J];Qilu Pharmaceutical Affairs;2010-02
7 ZHANG Jin-mei.Central Hospital of Tongchuan Mineral Bureau,Tongchuan 727000,China;Clinical Observe on Treating Ischemic Heart Disease and Atrial Fibrillation Unit Use WenXin Granule and Metoprolol[J];Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease;2008-11
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